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Study for prognosis of hepatitis C virus carriers among chronic hemodialysis patients and clarify the liver pathology by genetic analysis

Research Project

Project/Area Number 17K09096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionYasuda Women's University

Principal Investigator

KATAYAMA KEIKO  安田女子大学, 看護学部, 教授 (50304415)

Co-Investigator(Kenkyū-buntansha) 田中 純子  広島大学, 医系科学研究科(医), 教授 (70155266)
大久 真幸  広島大学, 医系科学研究科(医), 助教 (20727250)
杉山 文  広島大学, 医系科学研究科(医), 助教 (50778280)
秋田 智之  広島大学, 医系科学研究科(医), 助教 (80609925)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血液透析患者集団 / 肝炎ウイルス感染 / 生命予後 / 転帰調査 / 血清疫学調査 / C型肝炎ウイルス(HCV) / HCV抗体陽性率 / HCV RNA陽性率 / HBs抗原陽性率 / C型肝炎ウイルス感染 / 血液透析患者 / 遺伝子解析
Outline of Final Research Achievements

A cohort study of a hemodialysis patient group followed for a long period was aimed to investigate the risk factors to the mortality. It was revealed that the prevalence of HCV RNA positivity was higher as 12.0% comparing the general population, but recently the positive rate as for 7.0% trends to decrease among patients with the recent introduction of dialysis. As a result of analysis of life prognosis, DM was significantly associated with a poorer life prognosis. In addition HCV infection was significantly associated with poor life prognosis among recently introduced patients.

Academic Significance and Societal Importance of the Research Achievements

血液を介して感染するHCVやB型肝炎ウイルス(HBV)のハイリスク集団である血液透析患者集団の生命予後に、どのような要因が関係するのかについて、長期間にわたって追跡が可能であった本研究の対象集団に対して解析した結果、肝炎ウイルス感染率が減少傾向にある2002年以降の透析導入患者において、HCVに感染していること、HBVに感染していることが生命予後不良に関連することが明らかとなった。著効率の高い直接作用型抗ウイルス(DAA)治療が推進されている現在、HCVに感染している血液透析患者への抗ウイルス治療等の治療選択を考える上での有用な基礎的データを得た。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 18 years follow-up large cohort study on epidemiology of hepatitis C among hemodialysis patients, their long term prognosis and related risk factors.2019

    • Author(s)
      KoKo, Nagashima S, Yamamoto C,Akita T, Ohisa M, Sugiyama A, Katayama K, Takahashi K, Tanaka J.
    • Organizer
      HCV 2019 the 26th International Synposium on Hepatitis C Virus and Related Viruses
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A 18-year followed-up cohort study on long term prognosis related to hepatitis virus infection among hemodialysis patients in Hiroshima2018

    • Author(s)
      Ko K, Nagashima S, Yamamoto C, Chuon C, Boburjon M, Jasur J, Sugiyama A, Matsuo J, Katayama K, Takahashi K, Tanaka J
    • Organizer
      APASL(Asian Pacific Association for the Study of the Liver-Single Topic Conference 2018)
    • Related Report
      2018 Research-status Report
  • [Presentation] 透析患者コホート疫学調査2017-血液透析患者コホートの長期予後と死因に関する調査研究-2018

    • Author(s)
      Ko Ko、永島慎太郎、山本周子、Mutalov Boburjou、Juraev Jasur,杉山文、大久真幸、秋田智之、片山惠子、田中純子
    • Organizer
      第54回日本肝臓学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血液透析患者コホートを対象としたHCV疫学調査2017

    • Author(s)
      KoKo、永島慎太郎、 山本周子、Chuon Channarena、杉山文、片山惠子、田中純子
    • Organizer
      第42回 日本肝臓学会西部会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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