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Association between gut microbiota and lifestyle / lifestyle-related factors in a general population

Research Project

Project/Area Number 17K09099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionHirosaki University

Principal Investigator

Tokuda Itoyo  弘前大学, 医学研究科, 助教 (90792391)

Co-Investigator(Kenkyū-buntansha) 中路 重之  弘前大学, 医学研究科, 特任教授 (10192220)
倉内 静香  青森県立保健大学, 健康科学部, 講師 (60455730)
沢田 かほり  弘前大学, 医学研究科, 助教 (50624889)
相馬 優樹  弘前大学, 医学研究科, 助教 (60792372)
村下 公一  弘前大学, COI研究推進機構, 教授 (80794601)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords岩木健康増進プロジェクト / 腸内細菌叢 / 腹腔内脂肪 / 動脈硬化関連項目 / 食事習慣 / 生活習慣病 / 生活習慣 / 腸内細菌叢機能 / 岩木プロジェクト健診 / 社会医学 / 栄養学
Outline of Final Research Achievements

The association between lifestyle/lifestyle-related factors and gut microbiota were studied in a general population. The results were as follows. At the gate level, Firmicutes phylum was low and Bacteroidetes phylum was high in men with high visceral fat area (VFA). In women with high VFA, Firmicutes phylum was high, and Bacteroidetes phylum and Actinobacteria phylum were low. At the genus level, a negative correlation was found between VFA and Blautiagenus genus / Bifidobacterium genus. On the other hand, regarding gut microbiota, arteriosclerosis-related items, and nutrient intake, A positive correlation was found between Firmicutes phylum and protein intake and total dietary fiber intake, while a negative correlation was found between Firmicutes phylum and blood glucose and alcohol intake. A positive correlation was found between Bacteroidetes phylum and alcohol intake.

Academic Significance and Societal Importance of the Research Achievements

Blautia属は腸内に多く存在する細菌であり、体内で肥満を解消するはたらきがある酪酸や酢酸をつくり出すほか、糖尿病、肝硬変、大腸がん、関節リウマチの患者で減少していることが報告されている。今回、Blautia属と腹腔内脂肪面積とに負相関がみられ、上記疾患改善や肥満、糖尿病の新たな指標となる可能性が示唆された。
これまでの研究より、肥満症患者などでFirmicutes門の増加、Bacteroidetes門の減少が報告されているが、本研究では体重、BMIとの相関はみられなかった。しかし、Firmicutes門、Bacteroidetes門がアルコール摂取と関連し肥満に関与する可能性が考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Blautia genus associated with visceral fat accumulation in adults 20-76 years of age.2019

    • Author(s)
      Ozato N, Saito S, Yamaguchi T, Katashima M, Tokuda I, Sawada K, Katsuragi Y, Kakuta M, Imoto S, Ihara K, Nakaji S
    • Journal Title

      NPJ Biofilms Microbiomes.

      Volume: 5:28 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41522-019-0101-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A microbial genus in the human gut associated with visceral fat regardless of sex2019

    • Author(s)
      Naoki Ozato, Shinichiro Saito, Tohru Yamaguchi, Mitsuhiro Katashima, Itoyo Tokuda, Kaori Sawada, Yoshihisa Katsuragi, Masanori Kakuta, Seiya Imoto, Kazushige Ihara, Shigeyuki Nakaji
    • Organizer
      26th European Congress on Obesity
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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