Clarification of the relationship between the success or failure of Helicobacter pylori eradication and the patient's lifestyle and constitution

• Project/Area Number: 17K09105
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Ozeki Kayoko 浜松医科大学, 医学部, 特任研究員 (70780625)
• Co-Investigator(Kenkyū-buntansha): 尾島 俊之 浜松医科大学, 医学部, 教授 (50275674) ; 古田 隆久 浜松医科大学, 臨床研究センター, 病院教授 (10303546)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ピロリ除菌 / 飲酒習慣 / 非特異的IgE値 / ピロリ菌除菌 / 血液検査 / 抗生物質感受性 / 除菌回数 / 飲酒回数 / 性差 / ヘリコバクター・ピロリ除菌 / ライフスタイル / 体質

Outline of Final Research Achievements

Increasing the eradication rate of Helicobacter pylori, which is known to cause gastric cancer and gastric ulcer, is one of the most important issues in terms of prevention. The purpose of this study was to examine the relationship between the success or failure of eradication of H. pylori in patients taking H. pylori eradication drugs and their physical characteristics and lifestyle.
The results of the analysis using a self-administered questionnaire and blood tests revealed an association between the difficulty of eradication and women's drinking habits, as well as an association between the difficulty of eradication and nonspecific IgE levels.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、ピロリ菌除菌失敗のリスク要因としても日常的な飲酒は好ましくないことが検証されたため、特に女性においては除菌が必要とされる状態になった場合を想定しても、飲酒習慣は避けるべきであることが示唆された。
また非特異的IgE高値の患者（花粉症等アレルギー疾患を持つ患者等が想定される）は除菌が難しいことが明らかとなったため、アレルギー体質の患者は、除菌されづらい可能性を鑑みて、除菌薬の飲み忘れ等に、より強い注意喚起が必要であることが示唆された。

Research Products

• [Journal Article] Association Between Patients’ Immunoglobulin E Levels and Difficulty Eradicating Helicobacter pylori (2021)
  • Author(s): Ozeki Kayoko、Furuta Takahisa、Ojima Toshiyuki
  • Journal Title: Clinical and Experimental Gastroenterology Volume: Volume 14 Pages: 311-316
  • DOI: 10.2147/ceg.s322512
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between primary eradication of Helicobacter pylori and drinking habits in women: collaborative research between a pharmacy and a clinic (2019)
  • Author(s): Ozeki Kayoko、Asano Michio、Furuta Takahisa、Ojima Toshiyuki
  • Journal Title: Epidemiology and Infection Volume: 147
  • DOI: 10.1017/s0950268819001730
  • Peer Reviewed / Open Access
• [Presentation] ピロリ菌除菌患者における飲酒とIgE高値との関連 (2022)
  • Author(s): 尾関佳代子、古田隆久、尾島俊之
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] ピロリ菌除菌回数とIgE値との関連 (2021)
  • Author(s): 尾関佳代子、尾島俊之
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] ピロリ菌除菌を2回以上失敗した患者と多量飲酒との関連 (2020)
  • Author(s): 尾関佳代子、尾島俊之
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] ピロリ菌感染者のFスケール問診票（胃食道逆流症の評価）のスコアと年齢との関連 (2019)
  • Author(s): 尾関佳代子、尾島俊之
  • Organizer: 日本疫学会
• [Presentation] Collaborative research between a pharmacy and a local clinic:Association between failed Helicobacter pylori eradication and drinking habit in women (2018)
  • Author(s): Kayoko Ozeki, Toshiyuki Ojima
  • Organizer: American Public Health Association
  • Int'l Joint Research
• [Presentation] ピロリ菌除菌と1週間の飲酒回数との関連 (2018)
  • Author(s): 尾関佳代子
  • Organizer: 日本疫学会
• [Book] 薬局から研究を発信しよう (2019)
  • Author(s): 尾関 佳代子
  • Total Pages: 157
  • Publisher: 薬事日報社
  • ISBN: 484081502X