| Project/Area Number |
17K09136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅地 孝能 金沢医科大学, 医学部, 教授 (00183137)
西野 善一 金沢医科大学, 医学部, 教授 (70302099)
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| Project Period (FY) |
2017-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | trimethylamine-N-oxide / BNP / CAVI / TMAO / 腸内フローラ / 動脈硬化 / 心機能 / 循環器疾患 |
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| Outline of Final Research Achievements |
In total, 166 subjects (102 men, 64 women; mean age, 63 years) were enrolled. The median value (tertile cut-off points) and standard-deviation (SD) of plasma trimethylamine-n-oxide (TMAO) levels were 0.335 (0.239, 0.515) and 1.323 μg/ml, and the means ± SD of cardio-ankle vascular index (CAVI) were 8.60 ± 1.12 including 23 high CAVI (>or=10.0). In women, only 4 subjects were cases of high CAVI and the oters were not identified in lowest tertile of plasma TMAO levels.
In unadjuted model, 1 higher SD of TMAO resulted in increasing high CAVI (OR 2.18, 95 % CI 1.22-2.23, p = 0.001) and high CAVI was identified in the highest tertile of TMAO compared to the lowest tertile (OR 3.90, 95 % CI 1.31-11.63, p = 0.015). In fully adjusted models, 1 higher SD of TMAO resulted in increasing high CAVI (OR 2.62, 95 % CI 1.18-3.35, p = 0.010) and high CAVI was identified in the highest tertile of TMAO compared to the lowest tertile (OR 2.99, 95 % CI 0.68-13.19, p = 0.148).
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| Academic Significance and Societal Importance of the Research Achievements |
当研究は高血漿TMAO濃度が動脈硬化症の独立した予測因子である可能性を示し、海外含め学会発表ができた。特に欧米人と食事内容が違い腸内フローラの特徴も違うと予想される日本人含めアジア人を対象としたものでは、TMAO値とCAVIとの関連についておそらく世界で初めて報告できた。現在も未解決と言える腸内フローラと動脈硬化および循環器疾患との関連について、一筋の光を差し込めたと考える。
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