Development visualization analysis system of multistate outbreak of enteric disease

• Project/Area Number: 17K09149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Yuichir Yahata 国立感染症研究所, 実地疫学研究センター, 主任研究官 (70346956)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 広域散発アウトブレイク / 三類感染症 / 分子タイピング / サーベイランス / 可視化 / 感染症 / 公衆衛生対策 / 情報の可視化 / 疫学調査 / 感染症広域散発アウトブレイク / 感染症発生動向調査 / 患者情報 / 病原体情報

Outline of Final Research Achievements

Regarding the category three infectious diseases such as Enterohemorrhagic Escherichia coli, Shigella, Cholera, Typhoid fever, and Paratyphoid fever, detection of the multijurisdictional outbreak is very difficult worldwide. The study developed the dashboard of the molecular subtyping for category three infectious diseases. The project could early detect the multijurisdictional outbreak and conduct early public health control measures. The next challenge will be more timely detection of outbreaks and to conduct more early public health control.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は広域散発アウトブレイク対策の為に、分子タイピングによるサーベイランス及び患者サーベイランスの情報を元に広域散発アウトブレイクの探知を可視化により行うことが出来るようになった。国内外で探知が困難である広域散発アウトブレイクの探知が科学的及び学術的に実施したことによるものであり、その結果に基づいて実施された公衆衛生対策が出来たことが社会的に意義があることであった。従って、本研究の遂行は学術的に意義があり、社会的にも意義があることが国民への健康への還元が出来る成果であると思われた。

Research Products

• [Journal Article] Multijurisdictional Outbreak of Enterohemorrhagic Escherichia coli O157 Caused by Consumption of Ready-to-Eat Grilled Skewered Meat in Niigata, Japan (2022)
  • Author(s): Ryosuke Sato, Yuichiro Yahata, Hiroyuki Taira, Tetsuya Saito, Teruyuki Ishii, Satoru Yamazaki, Kazunari Yamamoto, Ryoko Kikuchi, Hidemasa Izumiya, Sunao Iyoda, Makoto Ohnishi, Yoshiki Takahashi
  • Journal Title: Foodborne Pathogens and Disease Volume: - Issue: 6 Pages: 400-407
  • DOI: 10.1089/fpd.2021.0083
  • Peer Reviewed / Open Access
• [Journal Article] A shigellosis outbreak associated with a sports festival at a kindergarten in Kitakyushu City, Japan (2020)
  • Author(s): Kato Hirofumi、Yahata Yuichiro、Hori Yuko、Fujita Kagekiyo、Ooura Noriko、Kido Taeko、Yoshimoto Katsuhiko、Matsui Tamano、Izumiya Hidemasa、Ohnishi Makoto、Oishi Kazunori
  • Journal Title: Journal of Infection and Chemotherapy Volume: 26 Issue: 11 Pages: 1146-1151
  • DOI: 10.1016/j.jiac.2020.06.005
  • Peer Reviewed
• [Journal Article] A shigellosis outbreak associated with the sports festival at the kindergarten in Kitakyushu City, Japan (2020)
  • Author(s): Hirofumi Kato, Yuichiro Yahata, Yuko Hori, Kagekiyo Fujita, Noriko Ooura, Taeko Kido, Katsuhiko Yoshimoto, Tamano Matsui, Hidemasa Izumiya, Makoto Ohnishi, Kazunori Oishi
  • Journal Title: Journal of Infection and Chemotherapy Volume: -
  • Peer Reviewed
• [Presentation] Enterohemorrhagic Escherichia coli outbreaks in Japan: Lessons learnt and challenges with multi-prefectural outbreaks (2018)
  • Author(s): Yuichiro YAHATA
  • Organizer: 10th International Symposiium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections
  • Int'l Joint Research / Invited
• [Presentation] Enterohemorrhagic Escherichia Coli O157 outbreak among residents of a high school dormitory and community acquired sporadic case of multi-prefecture in August-September 2013, in Japan (2017)
  • Author(s): Yuichiro Yahata, Fumie Ando, Kunio Kawabata, Masami Nagira, Tomimasa Sunagawa, Tamano Matsui, Hidemasa Izumiya, Makoto Ohnishi, Kazunori Oishi
  • Organizer: Integrated Foodborne Outbreak Response Management Conference
  • Int'l Joint Research
• [Presentation] A multi-prefectural outbreak of E. coli O157 associated with sugarcane juice in Okinawa Prefecture, Japan, 2016 (2017)
  • Author(s): Ando F,Akamine R,Hosoda C,Yamashita M,Ikema M,Kishimoto A,Nakasone T,Miyamoto Y,Ohno S, Sakiyama H,Hirayasu A,Ohshiro T,Yonahara Y,Takara T,Nakama E,Kyan H,Kakita T,Kuba Y,KatoT,Kudaka J,Uezato H,Nidaira M,Yamauchi M,Yamakawa M,Matsui T,Oishi K,Izumiya H,Ohnishi M,Yahata Y,Sunagawa T,Azuma T,Itokazu T
  • Organizer: Integrated Foodborne Outbreak Response Management Conference
  • Int'l Joint Research