Multicenter study for preventing surgical site infection in orthopedic surgery
Project/Area Number |
17K09151
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Takimura Fumiaki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (80242147)
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Co-Investigator(Kenkyū-buntansha) |
宮崎 剛 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (50376480)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 手術部位感染 / 清潔手術 / 整形外科 / 他施設共同 / 多施設共同 / 予防医学 |
Outline of Final Research Achievements |
We performed a multicenter study including 7 tertiary referral hospitals in the greater Tokyo metropolitan area, enrolling patients undergoing clean orthopedic surgery. We explored data of complications within 30 days after surgery, including surgical site infection and death. From multivariate analyses, normothermia(>36℃) at the end of the surgery significantly decreased the risk of death in total study population. Moreover, operation duration of >180 min, estimated blood loss of >500ml, operation performed between August and October, and diabetes were significantly related with SSI risk in spinal surgery. Normothermia, operation duration and estimated blood loss are modifiable risk factors. Therefore, these risks should be carefully adjusted before surgery. We further developed a sliding scale for predicting major complication risks after surgery for posterior spine surgery. We believe our findings will improve patient safety among orthopedic surgeries.
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Academic Significance and Societal Importance of the Research Achievements |
未曽有の高齢化と共に、脊椎後方手術の重要性は増している。しかし、脊椎後方手術は手術侵襲が大きく、術後合併症リスクが高いことも問題となっている。本研究を元に術後リスクを予測し、無理な手術計画を控えていただくことで、高齢者に対しより安全な脊椎後方手術が行われるようになるのではないかと考えている。 今後もさらに解析を行い、SSIを中心とした整形外科術後合併症の特徴を正確につかみ、我々がより安全な手術を行っていくために必要な様々な情報を提供し、将来的により実践的な予防策につながる提案をしていきたい。また、本解析結果から得られた様々な仮説を検証すべく、今後はより検証的な研究を進めていきたいと考えている。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity.2019
Author(s)
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y
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Journal Title
Sci Adv
Volume: 5
Issue: 9
Pages: 7802-7802
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] MRSA-SSIの予防、診断と治療2018
Author(s)
山田 浩司, 岡崎 裕司, 田尻 康人, 時村 文秋, 山川 聖史, 松本 卓也, 金井 宏幸, 三上 容司, 苅田 達郎, 松下 和彦, 田中 栄
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Journal Title
日本整形外科学会雑誌
Volume: 92巻3号
Pages: 1144-1144
Related Report
Peer Reviewed
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[Journal Article] Revision with locking plate and sliding inlay bone graft for hypertrophic nonunion after combined treatment of Ender nails and teriparatide for atypical femoral stress fracture: A unique case report.2017
Author(s)
Akira Koshiishi, Hiroshi Hamaji, Yasuhiro Wada, Kimiteru Ito, Kei Wagatsuma, Kenji Ishii, Masakazu Kanetaka, Soichiro Kaneko, Shigehito Uezono, Naoko Shoda, Yorito Anamizu, Fumiaki Tokimura, and Tsuyoshi Miyazaki
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Journal Title
J Orthopedics Rheumatol.
Volume: 4
Pages: 01-06
Related Report
Peer Reviewed / Open Access
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[Presentation] Evaluation of Metal Artifact Reduction Software in PET Quantification for Artificial Knee Joint; Phantom Experiment2018
Author(s)
Takashi Ono, Kei Wagatsuma, Nozomi Ito, Kaiho Miyazaki, Tsuyoshi Miyazaki, Yutaka Suzuki, Yoshiro Kudo, Yasushi Unno, Masashi Kameyama, Yasushi Unno, Masashi Kameyama
Organizer
The 12th Congress of the World Federation of Nuclear Medicine and Biology
Related Report
Int'l Joint Research
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