| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The concept of developmental origins of health and disease” (DOHaD) has been proposed to link lifestyle-related diseases with the environmental conditions of the early life including the fetal period. Carcinogenic risk though gestational exposure is becoming an important theme for environmental carcinogenesis. Recently, we reported that gestational (transplacental) exposure to organic arsenical dimethylarsinic acid (DMA) enhanced lung and liver carcinogenesis in mice. In the present study, we demonstrated that transplacental exposure to DMA enhanced lung carcinogenesis via histone modification in mice. This finding indicated that the epigenetic alterations induced by arsenicals during the fetal period attribute to the increased risk of cancers in offspring and might serve as useful markers for risk assessment.
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