| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Neurodegenerative disorders including Alzheimer’s disease (AD) and Parkinson’s disease (PD) causes occur sporadically and it is generally agreed that they could arise through interactions among genetic and environmental factors. Methylmercury (MeHg), a neurotoxic metal, is considered to one of the major environmental hazards for neurodegenerative disorders. In this research project, we investigated whether there is an interaction between MeHg and neurodegenerative disorders. In addition, we tried to create oleanolic acid (OA) 3 -ortoester derivatives as anti-AD or anti-PD drug candidates. We found that overexpression of α-synuclein showed high sensitivity to MeHg compared to wild type cells. Treatment of OA-3-glucoside attenuated MeHg-induced α-synuclein-overexpressed cell death.
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