Cancer-prevention by aspirin and the mechanism, from the viewpoint of inflammation-related DNA damage and cancer stem cell
| Project/Area Number |
17K09168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
Ohnishi Shiho 鈴鹿医療科学大学, 薬学部, 助教 (80511914)
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| Co-Investigator(Kenkyū-buntansha) |
有馬 寧 (馬 寧) 鈴鹿医療科学大学, 医療科学研究科, 教授 (30263015)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がん化学予防 / 炎症 / アスピリン / DNA損傷 / 8-ニトログアニン / がん幹細胞 / 動物実験 / 分子予防 / がん予防 |
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| Outline of Final Research Achievements |
Inflammation is an important risk of cancer. It has been recognized to be causative and promotive of cancer. Epidemiological studies showed non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin decreases cancer incidence. Aspirin is expected to have chemopreventive effects on cancer. However, animal studies to confirm the efficacy of aspirin are still not enough. We have reported that 8-nitroguanine, a nitrative DNA damage, is hopeful marker for risk assessment of inflammation-related carcinogenesis. In this study, we revealed that cyclooxygenase (COX), 8-nitroguanine, and cancer-stem cells had important roles on inflammation-related carcinogenesis, by histochemical analyses using clinical cancer specimens infected both with Schistosoma haematobium (SH) and without SH. Furthermore, we successed to confirm the suppressive effect of aspirin on colorectal tumorigenesis in mice model.
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| Academic Significance and Societal Importance of the Research Achievements |
アスピリンは、疫学調査研究で大腸がんや乳がんなど種々のがんを抑制することが示され、がん予防効果が期待されている。しかし、アスピリンによる有効性が、統計学的に証明できないケースも多く報告されており、動物実験での有効性の証明が重要な課題であった。本研究で、マウスにおいてアスピリン投与による大腸がん抑制効果を確認できたこと、その分子機序の一端が明らかとなったことは、アスピリンによるがん化学予防薬としての可能性を検証するうえで有用な知見となることが期待される。
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Combination of RERG and ZNF671 methylation rates in ccfDNA: a novel biomarker for screening of nasopharyngeal carcinoma2020
Author(s)
Xu Y, Zhao W, Mo Y, Ma N, Midorikawa K, Kobayashi H, Hiraku Y, Oikawa S, Zhang Z, Huang G, Takeuchi K, Murata M.
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Journal Title
Cancer Sci.
Volume: Epub ahead of prin
Issue: 7
Pages: 2536-2545
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.2019
Author(s)
Tachibana Ryota, Umekawa Takashi, Yoshikawa Kento, Owa Takao, Magawa Shoichi, Furuhashi Fumi, Tsuji Makoto, Maki Shintaro, Shimada Kyoko, Kaneda K. Michiko, Nii Masafumi, Tanaka Hiroaki, Tanaka Kayo, Kamimoto Yuki, Kondo Eiji, Kato Ineko, Ikemura Kenji, Okuda Masahiro, et al.
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Journal Title
Scientific Reports
Volume: 9
Issue: 1
Pages: 234-234
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] DNA methylation biomarkers for nasopharyngeal carcinoma2020
Author(s)
Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Hatasu Kobayashi, Shinji Oikawa, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
Organizer
第90回日本衛生学会学術総会
Related Report
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[Presentation] Potential epigenetic biomarkers for nasopharyngeal carcinoma2019
Author(s)
Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Hatasu Kobayashi, Shinji Oikawa, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
Organizer
第78回日本癌学会学術総会
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