| Project/Area Number |
17K09277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
Satoh Fumiko 北里大学, 医学部, 教授 (70328128)
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| Co-Investigator(Kenkyū-buntansha) |
入江 渉 北里大学, 医学部, 講師 (80597352)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 入浴 / 突然死 / 法医解剖 / 心臓 / 加齢性変化 / 入浴中の急死 / 免疫組織化学 / 剖検 / 心房細胞 / 溺水 / 加齢 |
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| Outline of Final Research Achievements |
As aging progresses, the number of sympathetic nerve cells decreases, resulting in uneven distribution of sympathetic nerves, which may lead to the development of atrial fibrillation. The number of adrenergic and non-adrenergic fibers in the pulmonary vein was examined immunohistochemically in cases of sudden death during bathing and control cases. There was no statistically significant difference in the number of adrenergic fibers compared with the control cases, and it was considered that the association between acute death during bathing and the occurrence of atrial fibrillation was low. Sudden death during bathing In the heart of autopsy cases, age-related changes such as lipofuscin deposition, perivascular fibrosis, and non-uniformity of the myocardial nuclei were frequently observed, resulting in decreased cardiac function. It was thought that this was related to the sudden death during bathing.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、入浴中の急死の剖検例の心臓の病理所見を検討すると、心肥大、心臓の加齢性変化であるリポフスチンの沈着、Basophilic degeneration、血管周囲の線維化、心筋の核の大小不同が高頻度に発現していた。コントロール例として、20歳代～90歳代までの心臓疾患の有さない剖検例対象例として比較した。両者を比較すると、心臓の加齢性変化は同程度の発現頻度であり、特に入浴中の急死例に心臓の加齢性の変化が発現しているとは言えないと考えられた。加齢と共に、心臓には加齢性変化が高頻度に発現しており、これらの変化による心臓の機能低下が入浴中の急死に関与している可能性があると考えられた。
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