| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We have compiled serum and whole blood concentrations for each compound found in acute toxicological cases. The results were characterized as follows: (1) Concentrations of many compounds were less than two times higher in serum than in whole blood, and the ratio remained constant regardless of concentration. (2) The ratio was 1 regardless of concentration. (3) The serum and whole blood concentration ratio was reversed with a decrease in concentration. Although, phenothiazine in the whole blood was not detected in extracted samples using K-solute cartridges (diatomaceous earth-based solid phase), methyl t-butyl ether was effective for whole blood extraction using K-solute. These results suggest that phenothiazines antipsychotics extraction from serum and whole blood using diatomaceous earth-based solid-phase columns seems to have an affinity with the elution solvent.
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