Can long-term oral intake of olive oil inhibit promotion of colon cancer? : in vivo and in vitro trials

• Project/Area Number: 17K09307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Saga University
• Principal Investigator: Fujimoto Kazuma 佐賀大学, 医学部, 客員研究員 (50181392)
• Co-Investigator(Kenkyū-buntansha): 坂田 資尚 佐賀大学, 医学部, 助教 (50404158) ; 岩切 龍一 佐賀大学, 医学部, 准教授 (70232642) ; 鶴岡 ななえ 佐賀大学, 医学部, 助教 (90535759)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 大腸発がん / 発がんモデル動物 / アポトーシス / 大腸粘膜 / 小腸粘膜 / 培養細胞 / 脂質 / 消化管 / 発癌抑制 / 食事 / 消化管機能

Outline of Final Research Achievements

The present study aimed to examine the effect of the long time dietary intake of fat on colon carcinogenesis using the experimental rat models and the cultured cells. The corn oil included n-6 polyunsaturated fatty acids and the beef tallow included saturated fatty acids enhanced the carcinogenesis, whereas the fish oil included n-3 unsaturated fatty acids and the olive oil reduced the carcinogenesis. The variation in the carcinogenesis was due to the balance between the cell proliferation and apoptosis both in the colon mucosa and the intestinal mucosa.

Academic Significance and Societal Importance of the Research Achievements

食事中に含まれる脂質による侵襲は大腸癌の病因を考えるうえ重要であり、多くの疫学的研究が施行されてきた。今回の動物実験モデルや培養細胞を用いた実験で、脂質の長期摂取と長期摂取する脂肪の脂肪酸構成が、大腸に対する直接作用と小腸での解毒代謝を介して大腸発癌に重要な役割を果たすことを明らかにした。他の脂肪摂取とことなり、魚油とオリーブ油の長期摂取は大腸発癌に抑制的に働き、その作用機序として粘膜増殖とアポトーシスのバランスが重要であることが判明した。これらの結果は従来示されてきた疫学的研究結果と一致するものであった。

Research Products

• [Journal Article] Risk factors for delayed hemorrhage after colonic endoscopic mucosal resection in patients who did not receive antithrombotic therapy: retrospective analysis of 3844 polyps of 1660 patients (2019)
  • Author(s): Tsuruta S, Tominaga N, Ogata S, Tsuruoka N, Sakata Y, Shimoda R, Eguchi Y, Anzai K, Hara M, Fujimoto K
  • Journal Title: Digestion Volume: 100 Issue: 2 Pages: 86-92
  • DOI: 10.1159/000494455
  • Peer Reviewed
• [Journal Article] Cancer-adipose tissue interaction and fluid flow synergistically modulate cell kinetics, HER2 expression, and trastuzumab efficacy in gastric cancer (2018)
  • Author(s): Akutagawa T, Aoki S, Yamamoto H,Rikitake M, Iwakiri R, Fujimoto K, Toda S
  • Journal Title: Gastric Cancer Volume: 2１ Pages: 946-955
  • NAID: 40021694578
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines (2018)
  • Author(s): Chan FKL, Goh KL, Reddy N, Fujimoto K, Ho KY, Hokimoto S, Jeong YH, Kitazono T, Lee HS, Mahachai V, Tsoi KKF, Wu MS, Yan BP, Sugano K
  • Journal Title: Gut Volume: 67 Pages: 405-417
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-density collagen patch prevents stricture after endoscopic circumferential submucosal dissection of the esophagus: a porcine model (2017)
  • Author(s): Aoki S, Sakata Y, Shimoda R, Takezawa T, Oshikata-Miyazaki A, Kimura H, Yamamoto M, Iwakiri R, Fujimoto K, Toda S
  • Journal Title: Gastrointest Endosc Volume: 85 Issue: 5 Pages: 1076-1085
  • DOI: 10.1016/j.gie.2016.10.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 研究におけるデータ管理 (2020)
  • Author(s): 藤本一眞
  • Organizer: 第16回日本消化管学会総会学術集会
  • Invited
• [Presentation] Fluid flow stress modulates gastric carcinoma cell kinetics in cancer-adipose tissue interactions (2018)
  • Author(s): Akutagawa T, Aoki S, Sakata Y, Fujimoto K, Toda S
  • Organizer: Digestive Disease Week 2018 (AGA)
  • Int'l Joint Research
• [Presentation] 大腸癌発育進展におけるFusobacterium属の役割とエピゲノム胃常、免疫応答との関連 (2018)
  • Author(s): 樋髙秀憲、東元 健、古賀靖大、岩切龍一、能城浩和、藤本一眞、副島英伸
  • Organizer: 第14回日本消化管学会総会学術集会
• [Presentation] Fluid flow stress amplifies the proliferation of gastric carcinoma cells promoted by adipose tissue (2017)
  • Author(s): Akutagawa T, Fujimoto K, Aoki S, Toda S.
  • Organizer: Asian Pacific Digestive Week (APDS)2017
  • Int'l Joint Research