Kampo medicine as a promising antiviral adjuvant in an immunosuppressive state caused by tumours.
Project/Area Number |
17K09328
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Nippon Medical School |
Principal Investigator |
Takaku Shun 日本医科大学, 医学部, 講師 (50445813)
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Project Period (FY) |
2017-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 漢方薬 / 抗ウイルス細胞性免疫 / 担がん宿主 / 十全大補湯 / 免疫制御系細胞 / 抗ウイルス免疫 / 東洋医学 / 免疫学 / がん / ウイルス / 感染症 |
Outline of Final Research Achievements |
We tested whether oral administration of Japanese Kampo medicine juzentaihoto (JTT) plays a role in the improvement of antiviral cellular immunity in tumour-bearing hosts. Murine colorectal cancer CT26-bearing mice fed control or JTT diet were inoculated with recombinant vaccinia virus expressing HIV-1 gp160 (vSC25). Seven days post infection, anti-vSC25 cellular immunity was evaluated by the frequency of splenic viral-specific CD8+ T cells. JTT, despite the lack of antitumour effect, augmented anti-vSC25 cellular immunity in CT26-bearing mice. Depletion of either regulatory T cells or myeloid-derived suppressor cells also enhanced anti-vSC25 cellular immunity in tumour-bearing mice. However, JTT had no impact on the frequency of those immune-suppressive cells. Taken together, JTT may contribute to the enhancement of anti-vSC25 cellular immunity in tumour-bearing hosts, suggesting that it can act as a promising antiviral adjuvant in immunosuppressive state caused by tumours.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の結果は、新興・再興感染症に対して特異的ワクチンや薬剤が開発されるまで対症療法で凌ぐしかない今日において、比較的安全性が高く経済的な十全大補湯ががん患者をはじめとする免疫低下した患者群に対して有用である可能性を示唆するものである。また感染症治療は病原体自体への対応に目が行きがちであるが、宿主の免疫の向上という視点に立ったアプローチも必要であり、本研究はその一端を示したものとも言えよう。古来より感染症の治療や予防などに多様な漢方薬が使用されてきたことを考えると、今後、科学的な観点から同様の研究を推進し易感染性宿主に対する感染症への備えを固めることは有用であると信ずる。
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Report
(7 results)
Research Products
(8 results)
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[Journal Article] Detection Method for Aquatic Bacteria of the Fingers, as a Potential Origin of the Aqueous Solution Contamination2017
Author(s)
Osono, E. Honda, K. Inoue, Y. Norose, Y. Takahashi, M. Ichimura, K. Kamano, C. Shinya, E. Takaku, S. Okamatsu, K. Kawamoto, S. Takizawa, H. Takahashi, H.
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Journal Title
Biocontrol Science
Volume: 22
Issue: 1
Pages: 61-65
DOI
NAID
ISSN
1342-4815, 1884-0205
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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