Study of molecular basis of motilin and growth hormone secretagogue receptor
| Project/Area Number |
17K09350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
Matsuura Bunzo 愛媛大学, 医学系研究科, 寄附講座教授 (80284420)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | モチリン受容体 / グレリン受容体 / 受容体活性化機構 / 受容体脱感作機構 / トランスジェニックマウス / 脳-消化管連関 / 脳消化管連関 / 受容体相互連関 / ユビキチン |
|---|
| Outline of Final Research Achievements |
Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor (MLNR) and growth hormone secretagogue receptor (GHSR). We have clarified pre-stimulation with motilin induces desensitization of MLNR, while that with erythromycin or other macrolides do not. We also have clarified the level of acyl-ghrelin is significantly attenuated by MLNR agonist administration in MLNR transgenic mice.
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| Academic Significance and Societal Importance of the Research Achievements |
モチリン受容体アゴニストが，種々の疾患や薬物による消化管運動機能障害を改善することから，現在モチリン受容体アゴニストとして臨床使用が可能なエリスロマイシン治療の有用性が確立された。またモチリン受容体TGマウスは，消化管運動機能改善物質のスクリーニングに有用なシステムであることが明らかとなった。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Free testosterone concentration is inversely associated with markers of liver fibrosis in men with type 2 diabetes mellitus2017
Author(s)
Miyauchi S, Miyake T, Miyazaki M, Eguchi T, Niiya T, Yamamoto S, Senba H, Furukawa S, Matsuura B, Hiasa Y
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Journal Title
Endocrine Journal
Volume: 64
Issue: 12
Pages: 1137-1142
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH)2017
Author(s)
Utsunomiya H, Yamamoto Y, Takeshita E, Tokumoto Y, Tada F, Miyake T, Hirooka M, Abe M, Kumagi T, Matsuura B, Ikeda Y, Hiasa Y
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Journal Title
J Gastroenterol
Volume: 印刷中
Issue: 8
Pages: 940-954
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Increase of serum chylomicron triglyceride concentration associated with intestinal overproduction of chylomicron triglyceride in nonobese, nondiabetic and normolipidemic NASH patients.2017
Author(s)
Utsunomiya N, Hanayama M, Yamamoto Y, Takeshita E, Tokumoto Y, Miyake T, Hirooka M, Kumagi T, Matsuura B, Abe M, Ikeda Y, Hiasa Y
Organizer
AASLD meeting 2017
Related Report
Int'l Joint Research
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