Determination of underlying cause of esophageal achalasia by the use of cytokine profiles
Project/Area Number |
17K09351
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kyushu University |
Principal Investigator |
Ihara Eikichi 九州大学, 医学研究院, 准教授 (80612390)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 食道アカラシア / 高解像度食道内圧検査 / サイトカインプロフィール / 経口内視鏡的筋層切開術 / 食道赤ラシア |
Outline of Final Research Achievements |
Esophageal achalasia is classified into three subtypes including Type I, Type II and Type III. From the viewpoint of immune and inflammatory responses, it has been shown that both Type I and Type II are Th1 and Th17-associated disorders while Type III are simply Th17-associated disorder. By discrimination analysis using esophageally expressed cytokine profiles, there was a significant difference in the cytokine profiles among three subtypes in accordance with difference in the finding of esophageal manometry results. On the other hand, a prospective observational study to examine usefulness of acotiamide for esophagogastric outflow obstruction (EGJOO), a precursor of achalasia, has revealed that 52 % of the patients with EGJOO was cured.
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Academic Significance and Societal Importance of the Research Achievements |
食道アカラシアとその前駆状態とされるEGJOOは、胸のつかえ症状から生活の質や労働生産性を低下させると共に致死的となる誤嚥性肺炎を合併するため高齢化社会を迎えた本邦において重要な疾患であるが、未だ病因・病態は解明されておらず治療は確立していない。本研究の学術的意義は、食道粘膜サイトカインプロフィールの観点からこの2つの疾患の病態の一端を解明したことである。また、本研究の社会的意義は、アコチアミドがEGJOOの治療薬及び食道アカラシアの予防薬となる可能性を示し、本邦の社会的ニーズである2つの疾患の治療法の開発へ直結するエビデンスを得たことである。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Involvement of different receptor subtypes in prostaglandin e2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body.2019
Author(s)
Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y
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Journal Title
Eur J Pharmacol
Volume: 857
Pages: 172405-172405
DOI
Related Report
Peer Reviewed
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[Journal Article] Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function.2018
Author(s)
Fukaura K, Ihara E, Ogino H, Iboshi Y, Muta K, Xiaopeng B, Hamada S, Hata Y, Iwasa T, Aso A, Nakamura K, Ogawa Y.
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Journal Title
Digestion
Volume: 98
Issue: 2
Pages: 95-103
DOI
Related Report
Peer Reviewed
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[Presentation] Mucosally expressed protease-activated receptor2 and transient receptor potential vanilloid1 are associated with functional heartburn.2018
Author(s)
Muta K, Ihara E, Hamada S, Fukaura K, Bai X, Otsuka Y, Ogino H, Bai X, Mukai K, Komori K, Hata Y, Mukai K, Komori K, Iwasa T, Akiho H, Nakamura K and Ogawa Y
Organizer
Digestive Disease Week 2018
Related Report
Int'l Joint Research
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[Presentation] The esophageal intraluminal baseline impedance differentiates reflux hypersensitivity from NERD.2018
Author(s)
Hamada S, Ihara E, Muta K, Fukaura K, Ogino H, Bai X, Mukai K, Otsuka Y, Komori K, Hata Y, Aso A, Iwasa T, Ochiai T, Akiho H, Nakamura K and Ogawa Y
Organizer
Digestive Disease Week 2018
Related Report
Int'l Joint Research
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