Diagnostic and therapeutic application of p53 family in esophageal squamous cell carcinoma

• Project/Area Number: 17K09354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Sapporo Medical University
• Principal Investigator: Sasaki Yasushi 札幌医科大学, 医療人育成センター, 教授 (70322328)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: p53 / p53ファミリー / 食道扁平上皮癌 / NGS / p53 family / p63 / 遺伝子変異 / トランスクリプトーム / 非コードRNA

Outline of Final Research Achievements

Genome sequencing studies of cancer have revealed the genomic landscapes of human cancer and have shown that the p53 tumor suppressor gene is most frequently mutated in cancers among the human genes. The p53 family is composed of a group of transcription factors, p53, p73, and p63. A high frequency of p53 mutation has been reported in esophageal squamous cell carcinoma (ESCC). Therefore, loss of p53 function is thought to be very important in ESCC. To identify the direct transcriptional targets of p53 family, we performed RNA sequencing (RNA-seq), chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) analyses and other functional assays. We have isolated several p53 family target transcripts, including protein-coding genes and non-coding RNAs. Our results indicated a p53 family-mediated transcriptional network involved in various biological functions and tumor suppression.

Academic Significance and Societal Importance of the Research Achievements

p53はヒト腫瘍において最も高頻度に変異を認めるがん抑制遺伝子である．予後不良な消化器癌である食道扁平上皮癌では70％以上の症例でp53変異が認められるが，変異p53自体は治療標的とはならず，有効な分子標的薬も存在しない．本研究では，食道扁平上皮癌においてp53ネットワーク破綻にともなって変化するトランスクリプトーム（蛋白コード遺伝子，非コードRNA）を網羅的に分析し，個々の関連分子の機能解析を行った．本研究結果は，p53 ネットワークによる腫瘍抑制メカニズムのさらなる理解とそれを標的とした食道扁平上皮癌の治療法開発の基盤形成につながる．

Research Products

• [Journal Article] Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction (2021)
  • Author(s): Iwaya Takeshi、Endo Fumitaka、Takahashi Fumiaki、Tokino Takashi、Sasaki Yasushi、Nishizuka Satoshi S.
  • Journal Title: Gastroenterology Volume: 160 Issue: 1 Pages: 463-465
  • DOI: 10.1053/j.gastro.2020.09.035
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs (2020)
  • Author(s): Udagawa Chihiro、Sasaki Yasushi、Tanizawa Yasuhiro、Suemizu Hiroshi、Ohnishi Yasuyuki、Nakamura Yasukazu、Tokino Takashi、Zembutsu Hitoshi
  • Journal Title: PLOS ONE Volume: 15 Issue: 9 Pages: e0239614-e0239614
  • DOI: 10.1371/journal.pone.0239614
  • Peer Reviewed / Open Access
• [Journal Article] Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy (2020)
  • Author(s): Ishiguro Kazuya、Sasaki Yasushi、Takagi Yoshitake、Niinuma Takeshi、Suzuki Hiromu、Tokino Takashi、Hayashi Toshiaki、Takahashi Tohru、Igarashi Tetsuyuki、Matsuno Yoshihiro
  • Journal Title: Medicine Volume: 99 Issue: 35 Pages: e21938-e21938
  • DOI: 10.1097/md.0000000000021938
  • Peer Reviewed / Open Access
• [Journal Article] Mutation profiling of uterine cervical cancer patients treated with definitive radiotherapy (2020)
  • Author(s): Yoshimoto Yuya、Sasaki Yasushi、Murata Kazutoshi、Noda Shin-ei、Miyasaka Yuhei、Hamamoto Junko、Furuya Mio、Hirato Junko、Suzuki Yoshiyuki、Ohno Tatsuya、Tokino Takashi、Oike Takahiro、Nakano Takashi
  • Journal Title: Gynecologic Oncology Volume: 159 Issue: 2 Pages: 546-553
  • DOI: 10.1016/j.ygyno.2020.08.020
  • Peer Reviewed / Open Access
• [Journal Article] Integrated genetic and epigenetic analysis of cancer‐related genes in non‐ampullary duodenal adenomas and intramucosal adenocarcinomas (2020)
  • Author(s): Ota R、Sawada T、Tsuyama S、Sasaki Y、Suzuki H、Kaizaki Y、Hasatani K、Yamamoto E、Nakanishi H、Inagaki S、Tsuji S、Yoshida N、Doyama H、Minato H、Nakamura K、Kasashima S、Kubota E、Kataoka H、Tokino T、Yao T、Minamoto T
  • Journal Title: The Journal of Pathology Volume: 252 Issue: 3 Pages: 330-342
  • DOI: 10.1002/path.5529
  • Peer Reviewed / Open Access
• [Journal Article] Combination of KRAS and SMAD4 mutations in formalin‐fixed paraffin‐embedded tissues as a biomarker for pancreatic cancer (2020)
  • Author(s): Yokose Takahiro、Kitago Minoru、Matsuda Sachiko、Sasaki Yasushi、Masugi Yohei、Nakamura Yuki、Shinoda Masahiro、Yagi Hiroshi、Abe Yuta、Oshima Go、Hori Shutaro、Yusuke Fujita、Nakano Yutaka、Endo Yutaka、Abe Kodai、Tokino Takashi、Kitagawa Yuko
  • Journal Title: Cancer Science Volume: 111 Issue: 6 Pages: 2174-2182
  • DOI: 10.1111/cas.14425
  • Peer Reviewed / Open Access
• [Journal Article] Genetic analyses of mosaic neurofibromatosis type 1 with giant caf?‐au‐lait macule, plexiform neurofibroma and multiple melanocytic nevi (2020)
  • Author(s): Hida Tokimasa、Idogawa Masashi、Okura Masae、Sugita Shintaro、Sugawara Taro、Sasaki Yasushi、Tokino Takashi、Yamashita Toshiharu、Uhara Hisashi
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 6 Pages: 658-662
  • DOI: 10.1111/1346-8138.15327
  • Peer Reviewed / Open Access
• [Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum (2020)
  • Author(s): Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
  • Journal Title: PLoS One Volume: 15 Issue: 2 Pages: e0229262-e0229262
  • DOI: 10.1371/journal.pone.0229262
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis (2020)
  • Author(s): Fujita, Y. Matsuda, S. Sasaki, Y. Masugi, Y. Kitago, M. Yagi, H. Abe, Y. Shinoda, M. Tokino, T. Sakamoto, M. Kitagawa, Y.
  • Journal Title: Cancer Sci Volume: 111 Issue: 2 Pages: 739-748
  • DOI: 10.1111/cas.14268
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p53 (2020)
  • Author(s): Suzuki, N. Idogawa, M. Tange, S. Ohashi, T. Sasaki, Y. Nakase, H. Tokino, T.
  • Journal Title: Oncogene Volume: 39 Issue: 10 Pages: 2202-2211
  • DOI: 10.1038/s41388-019-1133-7
  • Peer Reviewed
• [Journal Article] Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene: Review of two recurrent/metastatic oral squamous cell carcinoma patients (2020)
  • Author(s): Ogi, K. Kobayashi, J. Nakagaki, T. Okamoto, J. Koike, K. Hirokawa, N. Someya, M. Sakamoto, H. Takada, K. Tokino, T. Sasaki, Y. Hiratsuka, H. Miyazaki, A.
  • Journal Title: Oral Oncol Volume: 102 Pages: 104509-104509
  • DOI: 10.1016/j.oraloncology.2019.104509
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer (2019)
  • Author(s): Idogawa, M. Nakase, H. Sasaki, Y. Tokino, T.
  • Journal Title: J Oncol Volume: 1 Pages: 4368068-4368068
  • DOI: 10.1155/2019/4368068
  • Peer Reviewed / Open Access
• [Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy (2019)
  • Author(s): Darwis, N. D. M. Nachankar, A. Sasaki, Y. Matsui, T. Noda, S. E. Murata, K. Tamaki, T. Ando, K. Okonogi, N. Shiba, S. Irie, D. Kaminuma, T. Kumazawa, T. Anakura, M. Yamashita, S. Hirakawa, T. Kakoti, S. Hirota, Y. Tokino, T. Iwase, A. Ohno, T. Shibata, A. Oike, T. Nakano, T.
  • Journal Title: Int J Mol Sci Volume: 20 Issue: 18 Pages: 4563-4563
  • DOI: 10.3390/ijms20184563
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors (2019)
  • Author(s): Fukamachi H、Kim SK、Koh J、Lee HS、Sasaki Y、Yamashita K、Nishikawaji T、Shimada S、Akiyama Y、Byeon SJ、Bae DH、Okuno K、Nakagawa M、Tanioka T、Inokuchi M、Kawachi H、Tsuchiya K、Kojima K、Tokino Takashi、Eishi Y、Kim YS、Kim WH、Yuasa Y、Tanaka S
  • Journal Title: Journal of Experimental & Clinical Cancer Research Volume: 38 Issue: 1 Pages: 127-127
  • DOI: 10.1186/s13046-019-1121-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Malignant paraganglioma of posterior mediastinum; a case report with genetic analysis (2019)
  • Author(s): Adachi Y, Mita H, Sasaki Y, Himori R, Onodera K, Nakamura M, Kikuchi T, Yamashita K, Yukinari Yoshida Y, Ishii Y, Endo T
  • Journal Title: Mol Clin Oncol Volume: 10 Pages: 10-16
  • DOI: 10.3892/mco.2018.1758
  • Peer Reviewed / Open Access
• [Journal Article] Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors (2018)
  • Author(s): Harada T、Yamamoto E、Yamano HO、Aoki H、Matsushita HO、Yoshikawa K、Takagi R、Harada E、Tanaka Y、Yoshida Y、Eizuka M、Yorozu A、Sudo G、Kitajima H、Niinuma T、Kai M、Sasaki Y、Tokino Takashi、Sugai T、Nakase H、Suzuki H
  • Journal Title: Journal of Gastroenterology Volume: 53 Issue: 12 Pages: 1241-1252
  • DOI: 10.1007/s00535-018-1481-z
  • Peer Reviewed / Open Access
• [Journal Article] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling (2018)
  • Author(s): Ishiguro Kazuya、Kitajima Hiroshi、Niinuma Takeshi、Ishida Tadao、Maruyama Reo、Ikeda Hiroshi、Hayashi Toshiaki、Sasaki Hajime、Wakasugi Hideki、Nishiyama Koyo、Shindo Tetsuya、Yamamoto Eiichiro、Kai Masahiro、Sasaki Yasushi、Tokino Takashi、Nakase Hiroshi、Suzuki Hiromu
  • Journal Title: Haematologica Volume: 104 Issue: 1 Pages: 155-165
  • DOI: 10.3324/haematol.2018.191262
  • Peer Reviewed / Open Access
• [Journal Article] Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy (2018)
  • Author(s): Nuryadi E、Sasaki Y、Hagiwara Y、Permata TBM、Sato H、Komatsu S、Yoshimoto Y、Murata K、Ando K、Kubo N、Okonogi N、Takakusagi Y、Adachi A、Iwanaga M、Tsuchida K、Tamaki T、Noda S、Hirota Y、Shibata A、Ohno T、Tokino Takashi、Oike T、Nakano T
  • Journal Title: Oncotarget Volume: 9 Issue: 66 Pages: 32642-32652
  • DOI: 10.18632/oncotarget.25982
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1 (2018)
  • Author(s): Nishiyama K、Maruyama R、Niinuma T、Kai M、Kitajima H、Toyota M、Hatanaka Y、Igarashi T、Kobayashi J、Ogi K、Dehari H、Miyazaki A、Yorozu A、Yamamoto E、Idogawa M、Sasaki Y、Sugai T、Tokino Takashi、Hiratsuka H、Suzuki H
  • Journal Title: Cell Death & Disease Volume: 9 Issue: 8 Pages: 826-826
  • DOI: 10.1038/s41419-018-0893-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma (2018)
  • Author(s): Nakagaki Takafumi、Tamura Miyuki、Kobashi Kenta、Omori Akina、Koyama Ryota、Idogawa Masashi、Ogi Kazuhiro、Hiratsuka Hiroyoshi、Tokino Takashi、Sasaki Yasushi
  • Journal Title: Tumor Biology Volume: 40 Issue: 9 Pages: 0-0
  • DOI: 10.1177/1010428318800180
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment (2018)
  • Author(s): Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki, Tanaka, Yotsuyanagi, Tsutsumi, Yamamoto, Tokino T , Nakase H, Suzuki H, Itoh F
  • Journal Title: Cancer Letters Volume: 434 Pages: 91-100
  • DOI: 10.1016/j.canlet.2018.07.019
  • Peer Reviewed
• [Journal Article] Prognostic nutritional index and early mortality with percutaneous endoscopic gastrostomy (2018)
  • Author(s): Adachi Y, Akino K, Nojima M, Himori R, Kikuchi T, Mita H, Nakamura M, Tsukuda H, Yamano HO, Sasaki Y, Yoshida Y, Kato Y, Nakase H, Endo T
  • Journal Title: QJM Volume: 111 Issue: 9 Pages: 635-641
  • DOI: 10.1093/qjmed/hcy137
  • Peer Reviewed
• [Journal Article] Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma (2018)
  • Author(s): Takashima Yasuo、Sasaki Yasushi、Hayano Azusa、Homma Jumpei、Fukai Junya、Iwadate Yasuo、Kajiwara Koji、Ishizawa Shin、Hondoh Hiroaki、Tokino Takashi、Yamanaka Ryuya
  • Journal Title: Oncotarget Volume: 9 Issue: 44 Pages: 27471-27486
  • DOI: 10.18632/oncotarget.25463
  • Peer Reviewed / Open Access
• [Journal Article] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis (2018)
  • Author(s): Takahashi Youhei、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Ikeda Kimiyuki、Kobayashi Tomofumi、Ariki Shigeru、Takahashi Motoko、Sasaki Yasushi、Takahashi Hiroki
  • Journal Title: Respir Res Volume: 19 Issue: 1 Pages: 34-34
  • DOI: 10.1186/s12931-018-0736-9
  • Peer Reviewed / Open Access
• [Journal Article] Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs. (2018)
  • Author(s): Udagawa C, Sasaki Y, Suemizu H, Ohnishi H, Tokino T, Zembutsu H
  • Journal Title: Experimental and Therapeutic Medicine Volume: 15 Pages: 1339-1359
  • DOI: 10.3892/etm.2017.5533
  • Peer Reviewed / Open Access
• [Journal Article] Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. (2017)
  • Author(s): Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokino
  • Journal Title: International Joural of Cancer Volume: 印刷中 Issue: 12 Pages: 2785-2791
  • DOI: 10.1002/ijc.30689
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation. (2017)
  • Author(s): Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaski Y, Tokino T, Esumi M
  • Journal Title: PLoS One Volume: 12 Issue: 5 Pages: e0176280-e0176280
  • DOI: 10.1371/journal.pone.0176280
  • Peer Reviewed / Open Access
• [Journal Article] Fledglings in p53 signaling network. (2017)
  • Author(s): Tokino T, Idogawa M, Sasaki Y
  • Journal Title: Oncotarget Volume: 8 Issue: 34 Pages: 55768-55769
  • DOI: 10.18632/oncotarget.19229
  • Peer Reviewed / Open Access
• [Journal Article] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing. (2017)
  • Author(s): Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y
  • Journal Title: Oncotarget Volume: 8 Issue: 35 Pages: 59113-59122
  • DOI: 10.18632/oncotarget.19262
  • Peer Reviewed / Open Access
• [Journal Article] Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. (2017)
  • Author(s): Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y
  • Journal Title: Cancer Science Volume: 108 Issue: 12 Pages: 2413-2421
  • DOI: 10.1111/cas.13420
  • Peer Reviewed / Open Access
• [Presentation] 遺伝子パネルを用いたがんゲノム解析 (2019)
  • Author(s): 佐々木泰史
  • Organizer: 第120回北海道癌談話会例会
  • Invited
• [Presentation] Targeted exome sequencing profiles genetic alterations in oral squamous cell carcinoma from Japanese patients. (2019)
  • Author(s): Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T.
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2019
  • Int'l Joint Research
• [Presentation] The novel p53 family target BRMS1L suppresses cancer cell invasion and migration (2019)
  • Author(s): Sasaki Y, Koyama R, Maruyama R, Tamura M, Idogawa M, Suzuki H, Tokino T
  • Organizer: 11th AACR-JCA Joint International Conference
  • Int'l Joint Research
• [Presentation] 日本人口腔扁平上皮癌における全exome解析 (2019)
  • Author(s): 佐々木 泰史, 中垣 貴文, 荻 和弘, 丹下 正一朗, 井戸川 雅史, 宮崎 晃亘, 時野 隆至
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] The novel p53 family target BRMS1L suppresses cancer cell invasion and migration. (2019)
  • Author(s): Sasaki Y, Koyama R, Maruyama R, Tamura M, Idogawa M, Suzuki H, Tokino T
  • Organizer: 11th AACR-JCA Joint International Conference
  • Int'l Joint Research
• [Presentation] Amplicon-based targeted sequencing identifies promising markers in oral squamous cell carcinoma from Japanese patients (2019)
  • Author(s): Tokino T, Nakagaki T, Idogawa M, Sasaki Y
  • Organizer: 11th AACR-JCA Joint International Conference
  • Int'l Joint Research
• [Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR (2019)
  • Author(s): Iwaya T, Endo F, Sasaki Y, Sasaki N, Yaegashi M, Akiyama Y, Sasaki A, Masuda M, Yamada T, Tokino T, Nishizuka S
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2019
  • Int'l Joint Research
• [Presentation] BRMS1L, a metastatic suppressor gene, is transcriptionally regulated by p53 (2019)
  • Author(s): Tokino T, Koyama R, Idogawa M, Sasaki Y
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2019
  • Int'l Joint Research
• [Presentation] 口腔扁平上皮癌のhotspot変異解析 (2018)
  • Author(s): 佐々木泰史、中垣貴文、田村みゆき、井戸川雅史、荻和弘、平塚博義、時野隆至
  • Organizer: 第41回日本分子生物学会年会
• [Presentation] p53標的遺伝子BRMS1Lの同定と機能解析 (2017)
  • Author(s): 佐々木泰史，小山良太，田村みゆき，中垣貴文，大箸智子，井戸川雅史，時野隆至
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing (2017)
  • Author(s): Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma (2017)
  • Author(s): Iwaya T, Endo F, Kume K, Sasaki Y, Tokino T, Nishizuka S
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Exome sequencing of cancer-related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs (2017)
  • Author(s): Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H
  • Organizer: American Association of Cancer Research (AACR) annual meeting 2017
  • Int'l Joint Research
• [Presentation] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing (2017)
  • Author(s): Sasaki Y, Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima F, Idogawa M, Ogi K, Hiratsuka H, Tokino T
  • Organizer: The 12th International Workshop on Advanced Genomics
  • Int'l Joint Research
• [Remarks] 札幌医科大学生物学ホームページ
  • URL: https://web.sapmed.ac.jp/biol/index.html
• [Remarks] 札幌医科大学附属フロンティア医学研究所 ゲノム医科学部門
  • URL: http://web.sapmed.ac.jp/canmol/index.html