| Project/Area Number |
17K09361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NHPH / Helicobacter suis / Helicobacter heilmannii / PCR / 免疫組織化学 / 鳥肌胃炎 / 胃MALTリンパ腫 / MALT リンパ腫 / PCR法 / bilayer culture method / ハイルマニイ菌 / ピロリ菌陰性 / 慢性胃炎 / 培養 / 新興感染症 / 感染実態 |
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| Outline of Final Research Achievements |
The clinical significance of non-Helicobacter pylori Helicobacter (NHPH) is still unknown. There are many reports of NHPH-infected patients suffering from gastric diseases. Here we investigated the polymerase chain reaction (PCR) positivity of NHPH infection in gastric disease patients who were negative for Helicobacter pylori (Hp). Materials and Methods: We collected the 296 gastric mucosal samples of Hp-negative gastric disease patients from 17 hospitals in Japan from Sept 2013 to June 2019, and analysed the existence of Hp and NHPH by PCR. Results: Among the 236 non-Hp-eradicated cases, 49 cases (20.8%) were positive for NHPH. In all of these cases the NHPH diagnosed by PCR was successfully eradicated. I Among the 29 post-Hp eradication cases, three were NHPH-positive. Thus, approx. 20% of the Hp negative non-Hp-eradicated gastric disease patients treated at 17 hospitals in Japan were infected with NHPH.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は、10年以上にわたりNHPHの特徴、疾患形成との関連についての検討をカニクイザルおよびヒト由来菌のマウス感染モデルを用いて行ない、ピロリ菌との混合感染ではなくピロリ菌陰性者にNHPH感染例が多いことを見出した。今回の検討でも、さらに明確に認められたことから、ピロリ菌陰性の胃MALTリンパ腫、鳥肌胃炎、慢性胃炎、胃十二指腸潰瘍の20%にNHPHが関与することが明らかとなった。さらに、除菌後Hp陰性の症例で胃疾患が認められる場合、その10%にNHPHが陽性であることが示された。一方、除菌療法との関連ではHpと同様の薬剤の組み合わせによる除菌療法で全例が陰性化し、診断の重要性が明らかとなった。
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