The Effect of Proton-Pomp Inhibitors on the Gut Microbiota by Metagnome Approach
| Project/Area Number |
17K09365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University (2020, 2022)
National Center for Global Health and Medicine (2017-2018) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腸内細菌 / 口腔内細菌 / 機能代謝遺伝子 / KEGG / マイクロバイオーム / 薬剤使用 / 多剤併用 / 酸分泌抑制薬 / 薬剤 / マイクロバイオータ / P-CAB / プロトンポンプ阻害薬 |
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| Outline of Final Research Achievements |
Relationships between gut microbiota and PPIs, potassium competitive acid blockers (PCABs), and histamine H2 receptor antagonist (H2RA) use were examined. We found microbial signatures of PPI and PCAB were substantially overlapped, but not H2RA. Moreover, the proportion of multidrug-resistant bacteria (ESKAPE pathogens), which cause opportunistic infections, increased in the gut with PPI use, but not H2RA. A comprehensive microbial functional analysis identified more than 10,000 functional genes, among which PPI and PCAB were both characterized by findings of an elevated gene cluster related to amino acid metabolism, carbohydrate metabolism, and vitamin metabolism, but not H2RA. Administration of PPI showed an increase in bacteria of oral origin and pathogens after PPI use, but these species decreased with PPI discontinuation.
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| Academic Significance and Societal Importance of the Research Achievements |
薬剤の中でも消化器系の薬剤、とくにPPIやPCABなど薬剤が最も影響度が強い。PPIやPCAB使用に伴う腸内細菌叢への影響は、ほか薬剤併用による相加的効果、口腔内細菌の流入、細菌が担う食物代謝機能の更新、日和見菌増加などの広範囲に認められた。胃酸分泌抑制薬による腸内環境への負の影響を示唆するものであり、適正な薬剤投与の適応や投与期間を見直す意義が強調された。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Cumulative evidence for reducing recurrence of colonic diverticular bleeding using endoscopic clipping versus band ligation: Systematic review and meta-analysis.2020
Author(s)
Nagata N, Niikura R, Ishii N, Kaise M, Omata F, Tominaga N, Kitagawa T, Ikeya T, Kobayashi K, Furumoto Y, Narasaka T, Iwata E, Sugimoto M, Itoi T, Uemura N, Kawai T.
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Journal Title
Journal of Gastroenterology and Hepatology
Volume: Epub
Issue: 7
Pages: 1738-1743
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding2020
Author(s)
Niikura R, Nagata N, Yamada A, Honda T, Hasatani K, Ishii N, Shiratori Y, Doyama H, Nishida T, Sumiyoshi T, Fujita T, Kiyotoki S, Yada T, Yamamoto K, Shinozaki T, Takata M, Mikami T, Mabe K, Hara K, Fujishiro M, Koike K
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Journal Title
Gastroenterology
Volume: 158
Issue: 1
Pages: 168-168
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of bowel preparation on the human gut microbiome and metabolome2019
Author(s)
Nagata N, Tohya M,, Fukuda S,,,, Suda W, Nishijima S,0, Takeuchi F, Ohsugi M, Tsujimoto T, Nakamura T, Shimomura A, Yanagisawa N, Hisada Y, Watanabe K, Imbe K, Akiyama J, Mizokami M, Miyoshi-Akiyama T, Uemura N, Hattori M.
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Journal Title
Scientific reports
Volume: 11
Issue: 1
Pages: 4042-4042
DOI
Related Report
Peer Reviewed / Open Access
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