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Early diagnosis of small-bowel injuries related to rheumatoid arthritis using genome biomarker and capsule endoscopy

Research Project

Project/Area Number 17K09384
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionHiroshima University

Principal Investigator

Oka Shiro  広島大学, 病院(医), 講師 (30403538)

Co-Investigator(Kenkyū-buntansha) 田中 信治  広島大学, 病院(医), 教授 (00260670)
卜部 祐司  広島大学, 病院(医), 助教 (10648033)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsカプセル内視鏡 / 小腸粘膜傷害 / 関節リウマチ / 膠原病 / 早期診断 / 慢性関節リウマチ / 強皮症 / angioectasia / 内科 / 臨床
Outline of Final Research Achievements

Capsule endoscopy using flexible spectral imaging color enhancement is useful for the evaluation to diagnose the severity of the small-bowel lesions, and the detection of small-bowel mucosal injuries and angioectasias in patients with collagenous disease, especially for rheumatoid arthritis. The further analysis using genome biomarker is necessary to establish predictive factors of small-bowel lesions in patients with collagenous disease.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチを含む膠原病患者では、小腸粘膜傷害や血管性病変を合併するリスクがあり,その早期診断には分光画像処理機能を応用した小腸カプセル内視鏡検査が有用である。腹部症状や貧血などがある場合のみならず無症状であっても状況に応じて積極的に小腸カプセル内視鏡検査を施行すべきであり、早期診断と治療により改善が得られる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] The Clinical Usefulness of the PillCam Progress Indicator for Route Selection in Double Balloon Endoscopy2019

    • Author(s)
      Tsuboi A, Oka S, Tanaka S, Iio S, Otani I, Kunihara S, Chayama K.
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 10 Pages: 1375-1381

    • DOI

      10.2169/internalmedicine.2043-18

    • NAID

      130007649835

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-05-15
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Utility of Emergency Capsule Endoscopy for Diagnosing the Source and Nature of Ongoing Overt Obscure Gastrointestinal Bleeding2019

    • Author(s)
      Iio S, Oka S, Tanaka S, Tsuboi A, Otani I, Kunihara S, Chayama K.
    • Journal Title

      Gastroenterol Res Pract.

      Volume: 10 Pages: 1-6

    • DOI

      10.1155/2019/5496242

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] カプセル内視鏡を用いた全身性強皮症患者の小腸病変に関する検討2020

    • Author(s)
      飯尾澄夫、岡 志郎、茶山一彰
    • Organizer
      第106回日本消化器病学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 膠原病患者に対するカプセル内視鏡による小腸病変の診断2019

    • Author(s)
      飯尾澄夫、岡 志郎、茶山一彰
    • Organizer
      第98回日本消化器内視鏡学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 全身性強皮症患者に対するカプセル内視鏡検査の有用性2019

    • Author(s)
      飯尾澄夫、岡 志郎
    • Organizer
      第105回日本消化器病学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膠原病患者に対するカプセル内視鏡による小腸病変の診断2019

    • Author(s)
      飯尾澄夫、岡 志郎
    • Organizer
      第98回日本消化器内視鏡学会総会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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