Mechanisms of the water retention into the intestinal mucin that fluctuates depending on the pathological condition
| Project/Area Number |
17K09392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川島 麗 北里大学, 医療衛生学部, 准教授 (70392389)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ムチン / 水分子 / アクアポリン / 絶食 / 小腸 / PGM34 / 粘膜 / AQP3 / 水チャネル |
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| Outline of Final Research Achievements |
Mucins have a complex glycan structure, which may be related to their ability to retain water. The purpose of this study was to clarify the relationship between mucins and water molecules. In a mouse model of fasting, the expression of PGM34, a sulfomucin, was increased, and at the same time, the expression of aquaporin 3 molecules was also increased. This suggests that AQP3 is highly expressed in order to supply intracellular water molecules to the mucus layer using water channels, since fasting reduces the amount of water consumed, stagnates the metabolic turnover of epithelial cells, and decreases the ability to extract water from the lumen.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで臨床で汎用されてきた止瀉薬（下痢止め）は、管腔内の水分吸収作用を機序とするため、即効性はあるが根本治療にはつながらない。そこで、即効性がない反面、一度産生されると一定期間の産生維持と腸内環境改善が期待できるムチンという局面から腸内の水分調節を図るのが、効果的であると考えた。生体にとって最も重要な水をターゲットとした治療を提案することの危険性、つまり脱水や浮腫など全身性症状を引き起こす可能性がある一方で、ムチン関連性腸管特異的な水チャネルが存在したことから、慢性下痢症に対して安全かつ一時的でない治療の一助となると確信している。
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Report
(5 results)
Research Products
(39 results)
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[Journal Article] LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance <i>via</i> Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes2020
Author(s)
Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Makoto Kanzaki, Hiroko Maruyama, Rei Kawashima, Tatsunori Maekawa, Yoshifumi Kurosaki, Fumiaki Kojima, Takafumi Ichikawa.
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 43
Issue: 11
Pages: 1660-1668
DOI
NAID
ISSN
0918-6158, 1347-5215
Year and Date
2020-11-01
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] ヒートショックプロテイン72は血小板活性化因子によって誘導された血小板凝集を促進する2018
Author(s)
鈴木英明, 小菅優子, 石川勇太, 小林浩二, 五十嵐康之, 笹岡悠一, 田近洋介, 黒崎祥史, 井本明美, 石井直仁, 青山直善, 石原和彦, 市川尊文
Organizer
第58年会日本臨床化学会年次学術集会
Related Report
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[Presentation] HSP72 and anti-HSP72 antibodies control platelet aggregation induced by platelet activators in rats.2017
Author(s)
Suzuki H., Kosuge Y., Kobayashi K., Igarashi Y., Sasaoka Y., Kawakami F., Kawashima R., Imoto A., Kurosaki Y., Ishii N., Aoyama N., Ishihara K., Ichikawa T.
Organizer
The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine
Related Report
Int'l Joint Research
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