| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We evaluated serum of patients with HBV infection by monoclonal antibodies for small-HBsAg, glycosylated middle-HBsAg and large-HBsAg, those were obtained our novel system that can effectively detect antigen-specific cells. As the results, large-HBsAg was found independent of titer of HBV-DNA or HBsAg which is recognized with polyclonal antibody and is commercially available. Our results indicate that large HBsAg has a specific role in HBsAg biology. Our novel HBsAg detection system might provide a new insight in the study of HBV infection.
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