Establishment of antibody drug on non-alcoholic steatohepatitis through Met signaling.
| Project/Area Number |
17K09411
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梨井 康 国立研究開発法人国立成育医療研究センター, 移植免疫研究室, 室長 (60321890)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HGF / Met / 抗体医薬 / NASH / 再生医療 / 肝再生 |
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| Outline of Final Research Achievements |
HGF receptor Met makes a hybrid with insulin receptor and acts as a regulator for insulin sensitivity in the liver. The present study tried to establish new antibody drug therapy for NASH using Met-activating antibody. Treatment with Met-activating antibody on STAM mice (NASH model) did not show the significant decreased blood sugar or fatty liver, compared with control. However, treatment with Met-activating antibody on hepatectomized cirrhotic liver showed significant recovery of fibrosis, inflammation and regeneration and this effects continuedfor long period. Met-activating antibody can be used as an antibody drug for organ regeneration.
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| Academic Significance and Societal Importance of the Research Achievements |
dbdbマウスではMet作動性抗体を投与したところ血糖値、脂肪肝の改善を認めることからMet 作動性抗体はNASH治療に有効と考えられる。一方で肝硬変の肝切除モデルでは抗体投与群で著明な線維化・炎症の改善、肝再生の促進を認め、その効果は長く持続した。Met作動性抗体は抗体医薬としての安定性を示し、HGFが持つ多彩な作用を考えると、NASHのみならず幅広い組織修復・再生療法に有効である。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation.2019
Author(s)
Uto K, Sakamoto S, Que W, Shimata K, Hashimoto S, Sakisaka M, Narita Y, Yoshii D, Zhong L, Komohara Y, Li XK, Inomata Y, Hibi T
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Journal Title
BMC Gastroenterol
Volume: 19
Issue: 1
Pages: 25-25
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy.2019
Author(s)
Liu C, Zhu P, Fujino M, Isaka Y, Ito H, Takahashi K, Nakajima M, Tanaka T, Zhuang J, Li XK
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Journal Title
Biochem Biophys Res Commun
Volume: 508
Issue: 2
Pages: 583-589
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Combination of 5-aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft-versus-host disease.2018
Author(s)
Liu C, Yang X, Zhu P, Fujino M, Ito H, Takahashi K, Nakajima M, Tanaka T, Wang J, Zhuang J, Zou H, Li XK.
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Journal Title
Exp Dermatol.
Volume: 10
Issue: 10
Pages: 1104-1111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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