Analysis of liver repairing and regenerative capability of adipose tissue-derived stem cells obtained from the host with chronic liver disease

• Project/Area Number: 17K09413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: SAKAI YOSHIO 金沢大学, 医学系, 准教授 (80401925)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 間葉系幹細胞 / 脂肪組織 / 慢性肝疾患 / 内科 / 肝臓学 / 肝修復再生

Outline of Final Research Achievements

Chronic liver diseases ultimately lead to liver cirrhosis. We previously demonstrated that mesenchymal stem cells, which are pluripotent and immunomodulatory, are possibly therapeutic for hepatitis/cirrhosis when they are administered. In the current study, aiming that analysis of characteristics of adipose tisse-derived mesenchymal stem cells, and stromal cells in murine host with chronic liver disease, we obtained adipose tissue-derived stromal cells crhonologically from non-alcoholic steatohepatitis/cirrhosis murine models fed by atherogenic high-fat diet, as well as simple steatosis murine model, and analyzed sten cell-related surface antigens expressions of uncultured cells as well as gene expression profile. By these experiments, we obtained that fundamental data of chracteristics of adipose tissue-derived stromal cells of the host with chronic liver diseases.

Academic Significance and Societal Importance of the Research Achievements

慢性肝疾患は、その原因が除去あるいはコントロールされないと、重篤な合併症を伴う肝硬変状態に至る。特に、非アルコール性脂肪性肝炎・肝硬変は、近年増加し続けて重要な課題となってきている。これまでに我々は、多分化能および免疫修飾機能を有する間葉系幹細胞について、その投与による肝炎、肝硬変に対する治療の可能性を示してきた。医師主導治験として、「肝硬変に対する自己皮下脂肪組織由来再生（幹）細胞の経肝動脈投与による肝再生療法の有効性および安全性を検討する多施設共同非盲検非対照試験」を実施した。本研究では、肝疾患状態にあるマウス成体の脂肪組織由来間葉系幹細胞、間質細胞の特性の基礎的知見を得た。

Research Products

• [Journal Article] Regenerative Therapy for Liver Cirrhosis Based on Intrahepatic Arterial Infusion of Autologous Subcutaneous Adipose Tissue-Derived Regenerative (Stem) Cells: Protocol for a Confirmatory Multicenter Uncontrolled Clinical Trial. (2020)
  • Author(s): Y Sakai, S Fukunishi, M Takamura, O Inoue, S Takashima, S Usui, A Seki, A Nasti, T Ho, K Kawaguchi, A Asai, Y Tsuchiimura, T Muraymoto, T Yamashita, T Yamashita, E Mizukoshi, M Honda, Y Imai, K Yoshama, T Wada, K Harada, K Higuchi, S Kaneko
  • Journal Title: JMIR Res Protoc Volume: 9 Issue: 3 Pages: e17904-e17904
  • DOI: 10.2196/17904
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surrogacy of Time to Progression for Overall Survival in Advanced Hepatocellular Carcinoma Treated with Systemic Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2019)
  • Author(s): Terashima Takeshi、Yamashita Tatsuya、Toyama Tadashi、Arai Kuniaki、Kawaguchi Kazunori、Kitamura Kazuya、Yamashita Taro、Sakai Yoshio、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
  • Journal Title: Liver Cancer Volume: 8 Issue: 2 Pages: 130-139
  • DOI: 10.1159/000489505
  • Peer Reviewed / Open Access
• [Journal Article] Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity. (2019)
  • Author(s): Murai K, Honda M, Shirasaki T, Shimakami T, Omura H, Misu H, Kita Y, Takeshita Y, Ishii KA, Takamura T, Urabe T, Shimizu R, Okada H, Yamashita T, Sakai Y, Kaneko S.
  • Journal Title: Cell Host Microbe Volume: 10;25(4) Issue: 4 Pages: 588-601
  • DOI: 10.1016/j.chom.2019.02.015
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of impaired dendritic cell function in patients with hepatitis B virus infection. (2019)
  • Author(s): Yonejima A, Mizukoshi E, Tamai T, Nakagawa H, Kitahara M, Yamashita T, Arai K, Terashima T, Iida N, Fushimi K, Okada H, Yamashita T, Sakai Y, Honda M, Kaneko S.
  • Journal Title: Hepatology Volume: 10.1002/hep Issue: 1 Pages: 30637-30637
  • DOI: 10.1002/hep.30637
  • Peer Reviewed / Open Access
• [Journal Article] Adipose tissue‐derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL‐17‐mediated inflammation (2019)
  • Author(s): Yamato Masatoshi、Sakai Yoshio、Mochida Hatsune、Kawaguchi Kazunori、Takamura Masayuki、Usui Soichiro、Seki Akihiro、Mizukoshi Eishiro、Yamashita Taro、Yamashita Tatsuya、Ishida Kousuke、Nasti Alessandro、Tuyen Ho Thuy Bich、Komura Takuya、Yoshida Keiko、Wada Takashi、Honda Masao、Kaneko Shuichi
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 8 Pages: 1432-1440
  • DOI: 10.1111/jgh.14647
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells (2019)
  • Author(s): Sakai Yoshio、Honda Masao、Matsui Shigeyuki、Komori Osamu、Murayama Toshinori、Fujiwara Tadami、Mizuno Masaaki、Imai Yasuhito、Yoshimura Kenichi、Nasti Alessandro、Wada Takashi、Iida Noriho、Kitahara Masaaki、Horii Rika、Toshikatsu Tamai、Nishikawa Masashi、Okafuji Hirofumi、Mizukoshi Eishiro、et al
  • Journal Title: Cancer Science Volume: 110 Issue: 4 Pages: 1364-1388
  • DOI: 10.1111/cas.13971
  • Peer Reviewed / Open Access
• [Journal Article] Distinct chemotherapy-associated anti-cancer immunity by myeloid cells inhibition in murine pancreatic cancer models. (2019)
  • Author(s): Sakai Y, Miyazawa M, Komura T, Yamada T, Nasti A, Yoshida K, Takabatake H, Yamato M, Yamashita T, Yamashita T, Mizukoshi E, Okuzono M, Ho TTB, Kawaguchi K, Wada T, Honda M, Kaneko S.
  • Journal Title: Cancer Sci Volume: 110 Issue: 3 Pages: 903-912
  • DOI: 10.1111/cas.13944
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Three renal failure cases successfully treated with ombitasvir/paritaprevir/ritonavir for genotype 1b hepatitis C virus reinfection after liver transplantation. (2019)
  • Author(s): Orita N, Shimakami T, Sunagozaka H, Horii R, Nio K, Terashima T, Iida N, Kitahara M, Takatori H, Kawaguchi K, Kitamura K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Clin J Gastroenterol Volume: 12 Issue: 1 Pages: 63-70
  • DOI: 10.1007/s12328-018-0884-y
  • Peer Reviewed / Open Access
• [Journal Article] Notch signaling facilitates hepatitis B virus covalently closed circular DNA transcription via cAMP response element-binding protein with E3 ubiquitin ligase-modulation (2019)
  • Author(s): Wang Zijing、Kawaguchi Kazunori、Honda Masao、Hashimoto Shinichi、Shirasaki Takayoshi、Okada Hikari、Orita Noriaki、Shimakami Tetsuro、Yamashita Taro、Sakai Yoshio、Mizukoshi Eishiro、Murakami Seishi、Kaneko Shuichi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1621-1621
  • DOI: 10.1038/s41598-018-38139-5
  • Peer Reviewed / Open Access
• [Journal Article] Serum aldo-keto reductase family 1 member B10 predicts advanced liver fibrosis and fatal complications of nonalcoholic steatohepatitis. (2019)
  • Author(s): M Kanno, K Kawaguchi, M Honda, R Horii, H Takatori, T Shimakami, K Kitamura, K Arai, T Yamashita, Y Sakai, T Yamashita, E Mizukoshi, S Kaneko.
  • Journal Title: J Gastroenterol Volume: - Issue: 6 Pages: 549-557
  • DOI: 10.1007/s00535-019-01551-3
  • Peer Reviewed / Open Access
• [Journal Article] Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation. (2018)
  • Author(s): Fujinaga H, Sakai Y, Yamashita T, Arai K, Terashima T, Komura T, Seki A, Kawaguchi K, Nasti A, Yoshida K, Wada T, Yamamoto K, Kume K, Hasegawa T, Takata T, Honda M, Kaneko S.
  • Journal Title: Int J Radiat Biol Volume: 17 Issue: 5 Pages: 1-9
  • DOI: 10.1080/09553002.2019.1558297
  • Peer Reviewed / Open Access
• [Journal Article] The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication. (2018)
  • Author(s): Shirasaki T, Honda M, Yamashita T, Nio K, Shimakami T, Shimizu R, Nakasyo S, Murai K, Shirasaki N, Okada H, Sakai Y, Sato T, Suzuki T, Yoshioka K, Kaneko S.
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 13143-13143
  • DOI: 10.1038/s41598-018-31421-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immune Condition of Colorectal Cancer Patients Featured by Serum Chemokines and Gene Expressions of CD4+ Cells in Blood. (2018)
  • Author(s): Komura T, Yano M, Miyake A, Takabatake H, Miyazawa M, Ogawa N, Seki A, Honda M, Wada T, Matsui S, Kaneko S, Sakai Y.
  • Journal Title: Can J Gastroenterol Hepatol Volume: 7436205 Pages: 1-9
  • DOI: 10.1155/2018/7436205
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of the liver functional reserve of patients with advanced hepatocellular carcinoma undergoing sorafenib treatment: Prospects for regorafenib therapy. (2018)
  • Author(s): Terashima T, Yamashita T, Sunagozaka H, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Hepatol Res Volume: 48 Issue: 12 Pages: 956-966
  • DOI: 10.1111/hepr.13196
  • Peer Reviewed / Open Access
• [Journal Article] Distinct notch signaling expression patterns between nucleoside and nucleotide analogues treatment for hepatitis B virus infection. (2018)
  • Author(s): Wang Z, Kawaguchi K, Honda M, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
  • Journal Title: Biochem Biophys Res Commun Volume: 501 Issue: 3 Pages: 682-687
  • DOI: 10.1016/j.bbrc.2018.04.236
  • Peer Reviewed / Open Access
• [Journal Article] Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study. (2017)
  • Author(s): Hayashi T, Yamashita T, Terashima T, Suda T, Okada H, Asahina Y, Hayashi T, Hara Y, Nio K, Sunagozaka H, Takatori H, Arai K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 870-870
  • DOI: 10.1186/s12885-017-3889-x
  • Peer Reviewed / Open Access
• [Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo. (2017)
  • Author(s): Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16978-16978
  • DOI: 10.1038/s41598-017-17285-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus. (2017)
  • Author(s): Miyazawa M, Takatori H, Shimakami T, Kawaguchi K, Kitamura K, Arai K, Matsuda K, Sanada T, Urabe T, Inamura K, Kagaya T, Mizuno H, Fuchizaki U, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: e0188549-e0188549
  • DOI: 10.1371/journal.pone.0188549
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. (2017)
  • Author(s): Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.
  • Journal Title: Cancer Sci Volume: 108 Issue: 11 Pages: 2122-2129
  • DOI: 10.1111/cas.13396
  • Peer Reviewed / Open Access
• [Journal Article] The CD45+ fraction in murine adipose tissue derived stromal cells harbors immune-inhibitory inflammatory cells. (2017)
  • Author(s): Nasti A, Sakai Y, Seki A, Buffa GB, Komura T, Mochida H, Yamato M, Yoshida K, Ho TTB, Takamura M, Usui S, Wada T, Honda M, Kaneko S.
  • Journal Title: Eur J Immunol. Volume: 47 Issue: 12 Pages: 2163-2174
  • DOI: 10.1002/eji.201646835
  • NAID: 120006454989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B. (2017)
  • Author(s): Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
  • Journal Title: J Gastroenterol Volume: ePub ahead Issue: 6 Pages: 740-751
  • DOI: 10.1007/s00535-017-1386-2
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma. (2017)
  • Author(s): Terashima T, Yamashita T, Arai K, Kawaguchi K, Kitamura K, Yamashita T, Sakai Y, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Liver Cancer Volume: 6 Issue: 3 Pages: 236-249
  • DOI: 10.1159/000472262
  • Peer Reviewed / Open Access
• [Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet (2017)
  • Author(s): Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
  • Journal Title: Oncotarget Volume: 8 Issue: 25 Pages: 39978-39993
  • DOI: 10.18632/oncotarget.18116
  • Peer Reviewed / Open Access
• [Journal Article] Direct-acting antiviral agents improved nephrotic syndrome associated with refractory pleural effusion and ascites caused by hepatitis C virus-related nephropathy: a case report (2017)
  • Author(s): Yamato M, Arai K, Takatori H, Shimakami T, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 114 Issue: 6 Pages: 1031-1038
  • DOI: 10.11405/nisshoshi.114.1031
  • NAID: 130007330911
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed
• [Journal Article] Phase I clinical study of liver regenerative therapy for cirrhosis by intrahepatic arterial infusion of freshly isolated autologous adipose tissue-derived stromal/stem (regenerative) cell. (2017)
  • Author(s): Sakai Y, Takamura M, Seki A, Sunagozaka H, Terashima T, Komura T, Yamato M, Miyazawa M, Kawaguchi K, Nasti A, Mochida H, Usui S, Otani N, Ochiya T, Wada T, Honda M, Kaneko S
  • Journal Title: Regenerative Therapy Volume: 6 Pages: 52-64
  • DOI: 10.1016/j.reth.2016.12.001
  • Peer Reviewed / Open Access
• [Presentation] 非アルコール性脂肪性肝炎・肝硬変における細胞障害・線維化に対する脂肪組織由来間質細胞による肝修復機序の検討 (2019)
  • Author(s): 大和 雅敏、酒井 佳夫、金子周一
  • Organizer: 第43回肝臓学会西部会
• [Presentation] The combination of gemcitabine, anti-Ly6c and anti-PD-1 improves the efficacy of cancer immunotherapy in murine liver metastatic model of PDAC. (2019)
  • Author(s): Tuyen Thuy Bich Ho, Yoshio Sakai, Alessandro Nasti, Akihiro Seki, Shuichi Kaneko.
  • Organizer: 第48回日本免疫学会学術集会
• [Presentation] Immunomodulatory and repairing effect of adipose tissue-derived stromal/stem cells administration in non-alcoholic steatohepatitis mice. (2019)
  • Author(s): Yoshio Sakai, Akihiro Seki, Alessandro Nasti, Hiiro Inui, Kosuke Ishida, Kazunori Kawaguchi, Masatoshi Yamato, Takashi Wada, Shuichi Kaneko.
  • Organizer: CSH-asia
  • Int'l Joint Research
• [Presentation] 消化器がんの血液細胞にみられる生体反応と癌スクリーニング法開発研究 (2019)
  • Author(s): 酒井佳夫
  • Organizer: 第49回日本消化器がん検診学会東海北陸地区地方会
  • Invited
• [Presentation] . Investigator-initiated prospective clinical study of the novel blood biomarkers for pancreatic cancer. (2019)
  • Author(s): Yoshio Sakai, Shuichi Kaneko.
  • Organizer: JDDW 2019
• [Presentation] 脂肪組織由来間質細胞の肝硬変に対する治療効果の検討 (2019)
  • Author(s): 大和 雅敏、酒井 佳夫、金子 周一
  • Organizer: JDDW 2019
• [Presentation] Adipose tissue derived stromal/stem cells ameliorated unfolded protein response in NASH mice. (2019)
  • Author(s): Masatoshi Yamato, Yoshio Sakai, Hiiro Inui, Akihiro Seki, Keiko Yoshida, Ho Thuy Bich Tuyen, Alessandro Nasti, Takashi Wada and Shuichi Kaneko.
  • Organizer: The Liver Meeting 2019 AASLD.
  • Int'l Joint Research
• [Presentation] Characterization of uncultured adipose tissue-derived stromal/stem cells of murine steatohepatitis model for liver repairing/regenerative therapy. (2019)
  • Author(s): Alessandro Nasti, Yoshio Sakai, Masatoshi Yamato, Hiiro Inui, Kazunori Kawaguchi, Akihiro Seki, Takashi Wada, Shuichi Kaneko.
  • Organizer: The 17th International Congress of Immunology (IUIS 2019).
  • Int'l Joint Research
• [Presentation] 血液mRNA測定検査による膵癌スクリーニング法開発 (2019)
  • Author(s): 酒井佳夫、金子周一
  • Organizer: 第50回日本膵臓学会大会
• [Presentation] 膵癌マウスモデルに対するGemcitabine治療による骨髄由来細胞、CD8+細胞の応答 (2019)
  • Author(s): 酒井佳夫、小村卓也、宮澤正樹、金子周一
  • Organizer: 第50回日本膵臓学会大会
• [Presentation] 膵臓癌患者におけるCathepsin B/Cystatin A Axisの臨床的意義 (2019)
  • Author(s): 小村卓也、酒井佳夫、北川裕久、太田哲夫、原田憲一、金子周一
  • Organizer: 第50回日本膵臓学会大会
• [Presentation] 肝硬変に対する自己脂肪組織由来再生（幹）細胞の経肝動脈投与による再生療法開発研究 (2019)
  • Author(s): 酒井佳夫、福西新弥、高村雅之、薄井荘一郎、井上己音、朝井 章、川口和紀、大谷伸久、樋口和秀 、金子周一
  • Organizer: 第18回日本再生医療学会総会
• [Presentation] 肝硬変に対する自己脂肪組織由来再生（幹）細胞の経肝動脈投与による再生療法開発研究 (2019)
  • Author(s): 酒井佳夫、福西新弥、高村雅之、薄井荘一郎、井上己音、朝井 章、川口和紀、大谷伸久、樋口和秀、金子周一
  • Organizer: 第18回日本再生医療学会総会
• [Presentation] Adipose tissue-derived stromal/stem cells suppressed the hepatic stellate cell proliferation stimulated by hepatic inflammatory cell and IL-17A in murine non-alcoholic steatohepatitis (2018)
  • Author(s): Masatoshi Yamato, Yoshio Sakai, Alessandro Nasti, Shuichi Kaneko
  • Organizer: The 47th Annual Meeting of the Japanese Society for Immunology
• [Presentation] Anti-tumor immunity induced by gemcitabine in murine pancreas metastatic models is mediated by reduction of Gr-1+ cells and increment of cytocidal CD8+ T cells. (2018)
  • Author(s): Keiko Yoshida, Yoshio Sakai, Alessandro Nasti, Masatoshi Yamato, Shuichi Kaneko.
  • Organizer: The 47th Annual Meeting of the Japanese Society for Immunology
• [Presentation] Adipose Tissue Derived Stromal/Stem Cells Alleviated Hepatic Fibrosis Development Induced By IL17-Mediated Stellate Cell Activation in Nash Mice. (2018)
  • Author(s): Masatoshi Yamato, Yoshio Sakai, Hatsune Mochida, Dr. Akihiro Seki, Takuya Komura, Alessandro Nasti, Kazunori Kawaguchi, Takashi Wada, Masao Honda and Shuichi Kaneko.
  • Organizer: The Liver Meeting 2018 AASLD.
  • Int'l Joint Research
• [Presentation] mTORC2-Related Protein Kinase B Phosphorylation Is Associated with Notch Signaling Activation By Nucleotide Analogues for Chronic Hepatitis B Virus Infection. (2018)
  • Author(s): Kazunori Kawaguchi, Zijing Wang, Masao Honda, Hikari Okada, Takayoshi Shirasaki, Kouki Nio, Tetsuro Shimakami, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi and Shuichi Kaneko.
  • Organizer: The Liver Meeting 2018 AASLD.
  • Int'l Joint Research
• [Presentation] Elevation of Serum Aldo-Keto Reductase Family 1 Member B10 Is Associated with Advanced Liver Fibrosis in Non-Alcoholic Steatohepatitis. (2018)
  • Author(s): Masataka Kanno, Kazunori Kawaguchi, Masao Honda, Rika Horii, Hajime Takatori, Kazuya Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi and Shuichi Kaneko
  • Organizer: The Liver Meeting 2018 AASLD.
  • Int'l Joint Research
• [Presentation] ADSCs treatment hinders the advancement of fibrosis in liver in the early stage of NASH by reducing the Il17a-mediated inflammation. (2018)
  • Author(s): A. Nasti, Y. Sakai, M. Yamato, K. Kawaguchi, T. Ho, K. Yoshida, T. Komura, M. Takamura, T. Wada, M. Honda, S. Kaneko.
  • Organizer: 5th European Congress of Immunology, 2018.
  • Int'l Joint Research
• [Presentation] 膵臓癌マウスモデルにおけるGemcitabine治療が引き起こす宿主免疫応答の変化 (2018)
  • Author(s): 小村卓也、酒井佳夫、高畠央、吉田佳子、奥薗舞、ナスティ・アレッサンドロ、山田長司、金子周一
  • Organizer: 第49回日本膵臓学会大会
• [Presentation] 膵臓癌細胞株に対する陽子線・X線照射における遺伝子発現プロファイル変化の特徴 (2018)
  • Author(s): 藤永晴夫、酒井佳夫、山下竜也、荒井邦明、寺島健志、小村卓也、関晃裕、川口和紀、ナスティ・アレッサンドロ、吉田佳子、和田隆志、久米恭、長谷川崇、高田卓志、本多政夫、金子周一
  • Organizer: 第49回日本膵臓学会大会
• [Presentation] 肝線維化治療と肝再生医療の最新知見」WS8-2 自己脂肪組織由来間質細胞を用いた肝硬変治療開発の臨床研究 (2017)
  • Author(s): 酒井佳夫、関晃裕、金子周一
  • Organizer: 第103回日本消化器病学会総会
• [Presentation] 膵臓癌マウスモデルにおける宿主免疫応答状態の解明 (2017)
  • Author(s): 小村卓也、酒井佳夫、高畠央、金子周一
  • Organizer: 第48回日本膵臓学会大会
• [Presentation] Characteristics of inflammatory cells in liver metastasis tumor and intraperitoneal dissemination of murine pancreas cancer models. (2017)
  • Author(s): Takeshi Yamada, Yoshio Sakai, Takuya Komura, Keiko Yoshida, Ho Thuy Bich Tuyen, Alessandro Nasti, Mai Okusono, Hisashi Takabatake, Takashi Wada, Shuichi Kaneko.
  • Organizer: The Liver Meeting 2017 AASLD
• [Presentation] ADSC prevent progression of hepatic fibrosis by suppressing IL17A related inflammation in early stage of NASH. (2017)
  • Author(s): Masatoshi Yamato, Yoshio Sakai, Hatsune Mochida, Akihiro Seki, Keiko Yoshida, Ho Thuy Bich Tuyen, Alessandro Nasti, Takashi Wada and Shuichi Kaneko.
  • Organizer: The Liver Meeting 2017 AASLD.
• [Presentation] Immune-mediated cystatin A expression in patients with pancreatic ductaladenocarcinoma. (2017)
  • Author(s): Takuya Komura, Yoshio Sakai, Hisashi Takabatake, Kenichi Harada, Tetsuo Ohta, Hirohisa Kitagawa, Shuichi Kaneko.
  • Organizer: 2017 ESMO cancer immunology congress in Geneva.
  • Int'l Joint Research
• [Presentation] Features of immune response induced by Gemcitabine in pancreatic ductal adenocarcinoma models. (2017)
  • Author(s): Takeshi Yamada, Yoshio Sakai, Hisashi Takabatake, Takuya Komura, Shuichi Kaneko.
  • Organizer: The 46th Annual Meeting of the Japanese Society for Immunology, 2017.
  • Int'l Joint Research
• [Presentation] The CD45+ subset in murine uncultured adipose tissue-derived stromal cells features immune-inhibitory M2 macrophage-like cells contributable for therapeutics of acute hepatitis. (2017)
  • Author(s): Alessandro Nasti, Yoshio Sakai, Takeshi Yamada, Takuya Komura, Shuichi Kaneko.
  • Organizer: The 46th Annual Meeting of the Japanese Society for Immunology, 2017.
  • Int'l Joint Research
• [Presentation] 非培養マウス脂肪組織由来間質細胞による肝障害治療効果の検討 (2017)
  • Author(s): 酒井佳夫、Nasti, Alesssandro、吉田佳子、小村卓也、大和雅敏、石田晃介、川口和紀、餅田初音、薄井荘一郎、高村雅之、和田隆志、金子周一
  • Organizer: 第17回日本再生医療学会総会