| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
Liver tissue consists from endothelial cells, bile duct cells, immune cells and hepatocyte. Hepatitis B virus induces hepatitis and liver cancer, but the interaction and virus infection related signaling between these component cells are not still clarified. We analyzed these interactions by measuring gene expression in each component cells using single cell gene analysis. We clarified the intercellular signaling including Notch signaling activation and this interaction resulted in the involvement of transcription factors in hepatitis B virus infected cells. Results of analyzing clinical liver tissue found that these transcription factors or intercellular signaling were affected under nucleos(t)ide analogues treatment. In conclusion, intercellular signaling were found to be important in hepatitis B virus infected liver tissue.
|
