Analysis of disease specific T cell receptors in autoimmune liver diseases
Project/Area Number |
17K09416
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Shinshu University |
Principal Investigator |
Umemura Takeji 信州大学, 学術研究院医学系, 准教授 (30419345)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | AIH / PBC / HLA / KIR / Autotaxin / sCD14 / IL-8 / HLA-DPB1 / オートタキシン / SH2B3 / T細胞受容体 / 自己免疫性肝炎 / 原発性胆汁性胆管炎 |
Outline of Final Research Achievements |
We revealed several genes are associated with susceptibility and resistant to AIH. Moreover, combined KIR/HLA pair and cirrhosis at diagnosis related to AIH progression. Serum autotaxin are correlated with fibrosis in PBC. High sCD14 and IL-8 levels are associated with poor outcome of PBC.
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Academic Significance and Societal Importance of the Research Achievements |
本研究を通して原因不明の難病である自己免疫性肝炎と原発性胆汁性胆管炎の患者検体を用いて幾つかの血中バイオマーカー、ケモカイン、HLAやNK細胞の受容体などの宿主因子が発症、線維化の程度、病態の進展、生命予後に関連するという新たな研究成果を発表することができた。発見した因子を診断時に測定する事で予後を予測することが可能となれば早期から集約的な治療介入を開始することで患者さんの生命予後を延長することが可能となり得る。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis2018
Author(s)
Joshita, S. Umemura, T. Usami, Y. Yamashita, Y. Norman, G. L. Sugiura, A. Yamazaki, T. Fujimori, N. Kimura, T. Matsumoto, A. Igarashi, K. Yoshizawa, K. Ota, M. Tanaka, E.
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Journal Title
Sci Rep
Volume: 8
Issue: 1
Pages: 8159-8159
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey2018
Author(s)
Joshita, S. Yoshizawa, K. Umemura, T. Ohira, H. Takahashi, A. Harada, K. Hiep, N. C. Tsuneyama, K. Kage, M. Nakano, M. Kang, J. H. Koike, K. Zeniya, M. Yasunaka, T. Takaki, A. Torimura, T. Abe, M. Yokosuka, O. Tanaka, A. Takikawa, H. Japan Autoimmune Hepatitis Study, Group
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Journal Title
J Gastroenterol
Volume: 53
Issue: 9
Pages: 1079-1088
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between serum soluble CD14 and IL-8 levels and clinical outcome in primary biliary cholangitis2017
Author(s)
Umemura, T. Sekiguchi, T. Joshita, S. Yamazaki, T. Fujimori, N. Shibata, S. Ichikawa, Y. Komatsu, M. Matsumoto, A. Shums, Z. Norman, G. L. Tanaka, E. Ota, M.
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Journal Title
Liver International
Volume: 印刷中
Issue: 6
Pages: 897-905
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Association of Serum Autotaxin Levels with Disease Stages in Patients with Primary Biliary Cholangitis in Japanese patients2017
Author(s)
Joshita S, Umemura T, Usami Y, Sugiura A, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A, Igarashi K, Ota M, Tanaka E
Organizer
Asian Pacific Digestive Week
Related Report
Int'l Joint Research