| Project/Area Number |
17K09419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江口 暁子 三重大学, 医学系研究科, 特任講師(研究担当) (00598980)
山本 憲彦 三重大学, 医学部附属病院, 准教授 (60501963)
長谷川 浩司 三重大学, 医学部附属病院, 講師 (90737008)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルコール性肝障害 / 細胞外小胞 / 動脈硬化 / サルコペニア / 細胞外小胞体 / 消化器 / アルコール性肝炎 / 細胞伝達 |
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| Outline of Final Research Achievements |
Alcoholic liver disease (ALD) is strongly associated with arteriosclerosis. We have reported that damaged hepatocytes release extracellular vesicles (EVs) in ALD mice, thus we hypothesized that hepatocyte-derived EVs carry pathological information, such as cellular proteins and microRNAs, causing development of arteriosclerosis. In this study, we investigate the molecular mechanism of arteriosclerosis by hepatocyte-derived EVs. Using the alcoholic hepatitis mouse model, we observed the mild arteriosclerosis and abnormalities in muscle, suggesting that ALD is not only associated with arteriosclerosis but muscle damage. We detected proteins and microRNAs in hepatocyte-derived EVs that are associated with arteriosclerosis and muscle damage. We conclude that hepatocyte-derived EVs may contribute the progression of arteriosclerosis and muscle damage.
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| Academic Significance and Societal Importance of the Research Achievements |
アルコール性肝障害に合併する動脈硬化症とサルコペニアには障害肝細胞由来の細胞外小胞が病態情報伝播体として重要な役割を果たすことが示された。細胞外小胞を基軸とした「アルコール性肝障害・動脈硬化症・サルコペニア」のメカニズム解明、そして病態に関与する細胞外小胞をターゲットとしたバイオマーカーや治療法開発への展開が期待される。
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