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Establishment of tailor-made medicine for colorectal cancer arouse in serrated pathway

Research Project

Project/Area Number 17K09476
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionHiroshima University

Principal Investigator

Shinji Tanaka  広島大学, 病院(医), 教授 (00260670)

Co-Investigator(Kenkyū-buntansha) 卜部 祐司  広島大学, 病院(医), 助教 (10648033)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords鋸歯状腺癌 / serrated pathway / KRAS / BRAF / 早期大腸鋸歯状腺癌 / CDX2 / MSI / target-capture sequence / 早期鋸歯状腺癌 / colorectal cancer / pathogenesis / malignant potential / treatment
Outline of Final Research Achievements

The aim of this study was to clarify the characteristics for endoscopic, pathological, and molecular biological findings, and genomic alteration, associated with the poor prognosis pathway in serrated carcinogenesis. We examined the features in initial carcinogenesis development by early-stage serrated carcinomas (SACs). The results of this study found that Epithelial serration in the cancerous area indicated aggressive behavior in early-stage SACs, and Early-stage SACs were classified into three molecularly distinct subtypes with different clinicopathological and genetic characteristics.

Academic Significance and Societal Importance of the Research Achievements

Serrated pathwayは大腸癌の主な発癌経路の一つであり、予後不良な発癌経路として知られている。一方で、鋸歯状構造を有する腫瘍である鋸歯状腺腫からの大腸癌は全てserrated pathwayの様式をとって発癌するとは限らない。本研究の結果、鋸歯状腺癌は遺伝学的・病理学的に多様な発生機序を持つ疾患が混在していると考えられるため,鋸歯状腺癌の診断基準の細分化が必要となる可能性が示唆された。また,鋸歯状構造を伴う早期鋸歯状腺癌については悪性度が高いと考えられ、大腸内視鏡の治療選択の方針を選択する一つの指標となり得る可能性があると考えられた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes.2019

    • Author(s)
      Hirano D, Urabe Y, Tanaka S, Nakamura K, Ninomiya Y, Yuge R, Hayashi R, Oka S, Kitadai Y, Shimamoto F, Arihiro K, Chayama K.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 2 Pages: e0211477-e0211477

    • DOI

      10.1371/journal.pone.0211477

    • Related Report
      2018 Research-status Report
  • [Journal Article] Clinicopathologic and endoscopic features of early-stage colorectal serrated adenocarcinoma.2017

    • Author(s)
      Hirano D, Oka S, Tanaka S, Sumimoto K, Ninomiya Y, Tamaru Y, Shigita K, Hayashi N, Urabe Y, Kitadai Y, Shimamoto F, Arihiro K, Chayama K.
    • Journal Title

      BMC Gastroenterol

      Volume: 17 Issue: 1 Pages: 158-158

    • DOI

      10.1186/s12876-017-0702-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Examination for genetic and clinicopathological findings for early-stage serrated adenocarcinoma using CCS classification2018

    • Author(s)
      Yuji Urabe, Shinji Tanaka, Daiki Hirano, Koki Nakamura, Yuki Ninomiya, Ryohei Hayashi, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
    • Organizer
      The 77th Annual Meeting of the Japanese Cancer Associa
    • Related Report
      2018 Research-status Report
  • [Presentation] 大腸早期鋸歯状腺癌における 遺伝学的分類を用いた悪性度評価の有用性2018

    • Author(s)
      卜部祐司、平野大樹、岡 志郎、田中信治、茶山一彰
    • Organizer
      第109回 消化器病学会 中国地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] 早期大腸鋸歯状腺癌にたいする分子生物学的検討2018

    • Author(s)
      卜部祐司、田中信治、茶山一影
    • Organizer
      第97回日本消化器内視鏡学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Malignant potential of early-stage serrated adenocarcinoma based on genetic analysis2018

    • Author(s)
      Yuji Urabe, Shinji Tanaka, Daiki Hirano, Koki Nakamura, Yuki Ninomiya, Ryo Yuge, Ryohei Hayashi, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
    • Organizer
      UEGW2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 早期大腸鋸歯状腺癌の臨床病理学的および内視鏡的特徴.2017

    • Author(s)
      平野大樹, 田中信治, 茶山一彰.
    • Organizer
      第103回日本消化器病学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 臨床病理・分子生物学検討からみた早期大腸鋸歯状腺癌の特徴.2017

    • Author(s)
      平野大樹, 卜部祐司, 岡 志郎, 田中信治, 茶山一彰, 有廣光司.
    • Organizer
      第72回日本大腸肛門病学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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