| Project/Area Number |
17K09478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
猪股 雅史 大分大学, 医学部, 教授 (60315330)
衛藤 剛 大分大学, 医学部, 准教授 (00404369)
井上 高教 大分大学, 理工学部, 准教授 (40243969)
山岡 吉生 大分大学, 医学部, 教授 (00544248)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ピロリ菌治療 / 光線照射 / 内視鏡外科学 / ピロリ菌感染症 / 抗生物質耐性株 / 青色LED / 殺菌効果 / 電子顕微鏡 / Helicobacter pylori / 抗菌薬耐性 / LED |
|---|
| Outline of Final Research Achievements |
Irradiation of blue LEDs had a killing effect on antibiotic-resistant H. pylori strains against Amoxicillin, Clarithromycin, Levofloxacin, and Metronidazole, and one susceptible Helicobacter pylori (H. pylori) strain. It was found that H. pylori increased ROS production in H. pylori as a mechanism by which H. pylori was accompanied by morphological changes during the death process.
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| Academic Significance and Societal Importance of the Research Achievements |
1．複数のピロリ菌株への青色LED光線照射により死滅効果が確認でき、薬物療法を代替する治療あるいはその補助療法として臨床応用が期待できる。
2．薬剤耐性株に対しても死滅効果が確認できたため、薬剤耐性ピロリ菌感染者に対する新規治療法の足掛かりとなりうる。
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