Contribution of endotherial function and reactive oxygen species on the patogenesis of advanced heart failure

• Project/Area Number: 17K09488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Amiya Eisuke 東京大学, 医学部附属病院, 特任講師 (80529090)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 重症心不全 / 血管内皮機能 / 栄養状態 / サルコペニア / 一酸化窒素 / 呼吸筋疲労 / 補助人工心臓 / 肺拡散能 / 運動療法 / 心臓移植 / 活性酸素 / 心臓リハビリテーション

Outline of Final Research Achievements

I focused in the patients with left ventricular assist device (LVAD) and patients with congenital heart disease. I investigated the association between these patients and endothelial function, nutritional state or sarcopenia. The endothelial function in patients with LVAD was heavily determined by the kind of LVAD types. The clinical course of patients with LVAD could be predicted by the preoperative nutritional state, which was significantly related with right heart failure. In addition, The clinical course of patients with LVAD was heavily affected the presence of sarcopenia, which was exemplified by abdominal computed tomography.

Academic Significance and Societal Importance of the Research Achievements

重症心不全状態は心臓以外の栄養状態や血管内皮機能、サルコペニアと病態が関連することを確認した。重症度の高さから心不全治療では十分に解決できないケースも多い中で、心臓以外の事象との関連を示すことによって、新たな介入ポイントを示唆する結果とも考えられ、今後の新たな治療戦略の開発につながることが期待される。

Research Products

• [Journal Article] Case Report: A Case of Acute Cellular Rejection Due to Atopic Dermatitis Exacerbation 3 Years After Heart Transplantation. (2021)
  • Author(s): Kakuda N, Amiya E, Hatano M, Maki H, Bujo C, Tsuji M, Narita K, Fujita K, Ishida J, Ono M, Komuro I.
  • Journal Title: Front Immunol Volume: 12 Pages: 630051-630051
  • DOI: 10.3389/fimmu.2021.630051
  • Peer Reviewed / Open Access
• [Journal Article] Association between infectious event and de novo malignancy after heart transplantation. (2021)
  • Author(s): Bujo C, Amiya E, Hatano M, Tsuji M, Maki H, Ishida J, Ishii S, Narita K, Endo M, Ando M, Shimada S, Kinoshita O, Ono M, Komuro I
  • Journal Title: Heart Vessels Volume: 4 Issue: 4 Pages: 499-508
  • DOI: 10.1007/s00380-020-01715-9
  • Peer Reviewed
• [Journal Article] Fractional exhaled nitric oxide in adult congenital heart disease. Nitric Oxide (2020)
  • Author(s): Saito A, Amiya E, Soma K, Inaba T, Maki H, Hatano M, Yao A, Morita H, Komuro I.
  • Journal Title: Nitric Oxide Volume: 100 Pages: 45-49
  • DOI: 10.1016/j.niox.2020.05.001
  • Peer Reviewed
• [Journal Article] Differences in the prognoses of patients referred to an advanced heart failure center from hospitals with different bed volumes (2020)
  • Author(s): Narita K, Amiya E, Hatano M, Ishida J, Maki H, Minatsuki S, Tsuji M, Saito A, Bujo C, Ishii S, Kakuda N, Shimbo M, Hosoya Y, Endo M, Kagami Y, Imai H, Itoda Y, Ando M, Shimada S, Kinoshita O, Ono M, Komuro I.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 21071-21071
  • DOI: 10.1038/s41598-020-78162-z
  • Peer Reviewed / Open Access
• [Journal Article] Takotsubo syndrome in the same heart before and after heart transplantation. (2020)
  • Author(s): Tsuji M, Amiya E, Bujo C, Maki H, Ishida J, Hatano M, Ono M, Komuro I.
  • Journal Title: ESC Heart Fail Volume: 7 Issue: 6 Pages: 4311-4
  • DOI: 10.1002/ehf2.12970
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA-17: A Modulator of Interferon Regulatory Factor 9-Induced Phenotypic Switching in Vascular Smooth Muscle Cells (2020)
  • Author(s): Amiya E
  • Journal Title: Am J Hypertens Volume: 33 Issue: 12 Pages: 1078-1080
  • DOI: 10.1093/ajh/hpaa147
  • Peer Reviewed
• [Journal Article] Clinical importance of respiratory muscle fatigue in patients with cardiovascular disease (2020)
  • Author(s): Taya M, Amiya E, Hatano M, Saito A, Nitta D, Maki H, Hosoya Y, Minatsuki S, Tsuji M, Sato T, Murakami H, Narita K, Konishi Y, Watanabe S, Yokota K, Haga N, Komuro I.
  • Journal Title: Medicine (Baltimore) Volume: 99 Issue: 34 Pages: e21794-e21794
  • DOI: 10.1097/md.0000000000021794
  • Peer Reviewed / Open Access
• [Journal Article] Impact of tacrolimus versus cyclosporin A on renal function during the first year after heart transplant. (2020)
  • Author(s): Shiraishi Y, Amiya E, Hatano M, Katsuki T, Bujo C, Tsuji M, Nitta D, Maki H, Ishida J, Kagami Y, Endo M, Kimura M, Ando M, Shimada S, Kinoshita O, Ono M, Komuro I
  • Journal Title: ESC Heart Fail Volume: 7 Issue: 4 Pages: 1842-1849
  • DOI: 10.1002/ehf2.12749
  • Peer Reviewed / Open Access
• [Journal Article] Nrf-2: The Target of Vascular Dysfunction in Diabetes (2020)
  • Author(s): Amiya E
  • Journal Title: Am J Hypertens Volume: 33 Issue: 7 Pages: 597-598
  • DOI: 10.1093/ajh/hpaa052
  • Peer Reviewed
• [Journal Article] The Efficacy of Lactulose for the Treatment of Hyperammonemic Encephalopathy Due to Severe Heart Failure (2020)
  • Author(s): Narita Koichi、Amiya Eisuke、Kakuda Nobutaka、Kaneko Hidehiro、Hatano Masaru、Komuro Issei
  • Journal Title: Diagnostics Volume: 10 Issue: 2 Pages: 70-70
  • DOI: 10.3390/diagnostics10020070
  • Peer Reviewed / Open Access
• [Journal Article] Nrf-2: The Target of Vascular Dysfunction in Diabetes. (2020)
  • Author(s): Amiya E
  • Journal Title: Am J Hypertens Volume: in press Issue: 1
  • DOI: 10.1186/s13075-020-02171-6
  • Peer Reviewed
• [Journal Article] Controlling Nutritional Status Score As a Predictive Marker for Patients With Implantable Left Ventricular Assist Device (2020)
  • Author(s): Saito Akihito、Amiya Eisuke、Hatano Masaru、Shiraishi Yasuyuki、Nitta Daisuke、Minatsuki Shun、Maki Hisataka、Hosoya Yumiko、Tsuji Masaki、Bujo Chie、Nawata Kan、Kinoshita Osamu、Kimura Mitsutoshi、Endo Miyoko、Kagami Yukie、Nemoto Mariko、Ikeda Yuichi、Morita Hiroyuki、Ono Minoru、Komuro Issei
  • Journal Title: ASAIO Journal Volume: 66 Issue: 2 Pages: 166-172
  • DOI: 10.1097/mat.0000000000000972
  • Peer Reviewed
• [Journal Article] Inspiratory muscle training for advanced heart failure with lamin-related muscular dystrophy (2019)
  • Author(s): Taya Masanobu、Amiya Eisuke、Hatano Masaru、Maki Hisataka、Hosoya Yumiko、Ishida Junichi、Bujo Chie、Tsuji Masaki、Konishi Yuto、Yokota Kazuhiko、Haga Nobuhiko、Komuro Issei
  • Journal Title: Journal of Cardiology Cases Volume: 20 Issue: 6 Pages: 232-234
  • DOI: 10.1016/j.jccase.2019.09.007
  • Peer Reviewed
• [Journal Article] Variable Cardiac Responses to Immunosuppressive Therapy in Anti-Mitochondrial Antibody-Positive Myositis (2019)
  • Author(s): Bujo Satoshi、Amiya Eisuke、Kojima Toshiya、Yamada Shintaro、Maki Hisataka、Ishizuka Masato、Uehara Masae、Hosoya Yumiko、Hatano Masaru、Kubota Akatsuki、Toda Tatsushi、Komuro Issei
  • Journal Title: Canadian Journal of Cardiology Volume: 35 Issue: 11 Pages: 1604-1604
  • DOI: 10.1016/j.cjca.2019.07.002
  • Peer Reviewed
• [Journal Article] Significant impact of left ventricular assist device models on the value of flow-mediated dilation: effects of LVAD on endothelial function (2019)
  • Author(s): Watanabe A, Amiya E, Hatano M, Watanabe M, Ozeki A, Nitta D, Maki H, Hosoya Y, Tsuji M, Bujo C, Saito A, Endo M, Kagami Y, Nemoto M, Nawata K, Kinoshita O, Kimura M, Ono M, Komuro I.
  • Journal Title: Heart Vessels Volume: 20 Issue: 2 Pages: 207-213
  • DOI: 10.1007/s00380-019-01474-2
  • Peer Reviewed
• [Journal Article] Clinical impact of newly developed atrial fibrillation complicated with longstanding ventricular fibrillation during left ventricular assist device support: A case report (2019)
  • Author(s): Bujo Chie、Amiya Eisuke、Hatano Masaru、Tsuji Masaki、Maki Hisataka、Hosoya Yumiko、Fujii Emi、Kamon Tatsuya、Kojima Toshiya、Nawata Kan、Kinoshita Osamu、Kimura Mitsutoshi、Ono Minoru、Komuro Issei
  • Journal Title: BMC Cardiovascular Disorders Volume: 19 Issue: 1 Pages: 1604-1604
  • DOI: 10.1186/s12872-019-1132-1
  • Peer Reviewed / Open Access
• [Journal Article] Comment on “Improved Nutrition Status in Patients with Advanced Heart Failure Implanted with a Left Ventricular Assist Device” and Correlation Between Venous Congestion and Nutrition State (2019)
  • Author(s): Saito Akihito、Amiya Eisuke、Hatano Masaru
  • Journal Title: Nutrition in Clinical Practice Volume: 34 Issue: 5 Pages: 789-789
  • DOI: 10.1002/ncp.10322
  • Peer Reviewed
• [Journal Article] Progressive Right Ventricular Aneurysm in a Patient with Systemic Sarcoidosis (2019)
  • Author(s): Hirose Kazutoshi、Amiya Eisuke、Ishizuka Masato、Uehara Masae、Komuro Issei
  • Journal Title: Journal of Cardiovascular Imaging Volume: 27 Issue: 2 Pages: 158-158
  • DOI: 10.4250/jcvi.2019.27.e18
  • Peer Reviewed / Open Access
• [Journal Article] Abdominal skeletal muscle mass as a predictor of mortality in Japanese patients undergoing left ventricular assist device implantation (2019)
  • Author(s): Tsuji Masaki、Amiya Eisuke、Hatano Masaru、Nitta Daisuke、Maki Hisataka、Bujo Chie、Saito Akihito、Hosoya Yumiko、Minatsuki Shun、Hara Toru、Nemoto Mariko、Kagami Yukie、Endo Miyoko、Kimura Mitsutoshi、Kinoshita Osamu、Nawata Kan、Morita Hiroyuki、Ono Minoru、Komuro Issei
  • Journal Title: ESC Heart Failure Volume: 6 Issue: 3 Pages: 526-535
  • DOI: 10.1002/ehf2.12429
  • Peer Reviewed / Open Access
• [Journal Article] Influence of atrial fibrillation on oxygen uptake and exercise tolerance in cardiovascular patients; close association with heart rate response (2019)
  • Author(s): Takano Nami、Amiya Eisuke、Oguri Gaku、Nakayama Atsuko、Taya Masanobu、Nakajima Toshiaki、Morita Hiroyuki、Komuro Issei
  • Journal Title: IJC Heart & Vasculature Volume: 22 Pages: 84-91
  • DOI: 10.1016/j.ijcha.2018.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Enormous Aneurysm in Coronary Artery Fistula With Immunoglobulin G4-Related Disease. (2019)
  • Author(s): Kadowaki H. et al
  • Journal Title: Can J Cardiol. Volume: 2 Issue: 2 Pages: 230.e1-230.e3
  • DOI: 10.1016/j.cjca.2018.11.030
  • Peer Reviewed / Open Access
• [Journal Article] Is Exercise Training Appropriate for Patients With Advanced Heart Failure Receiving Continuous Inotropic Infusion? A Review. (2018)
  • Author(s): Amiya E, Taya M.
  • Journal Title: Clin Med Insights Cardiol Volume: Jan 3 Pages: 12-12
  • DOI: 10.1177/1179546817751438
  • Peer Reviewed / Open Access
• [Journal Article] Correction to: High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure (2018)
  • Author(s): Taya Masanobu、Amiya Eisuke、Hatano Masaru、Maki Hisataka、Nitta Daisuke、Saito Akihito、Tsuji Masaki、Hosoya Yumiko、Minatsuki Shun、Nakayama Atsuko、Fujiwara Takayuki、Konishi Yuto、Yokota Kazuhiko、Watanabe Masafumi、Morita Hiroyuki、Haga Nobuhiko、Komuro Issei
  • Journal Title: Heart and Vessels Volume: 33 Issue: 7 Pages: 760-761
  • DOI: 10.1007/s00380-018-1132-6
  • Peer Reviewed
• [Journal Article] Effect of Oral Branched-Chain Amino Acids on Serum Albumin Concentration in Heart Failure Patients with Hypoalbuminemia: Results of a Preliminary Study (2018)
  • Author(s): Uchino Yuichi、Watanabe Masafumi、Takata Munenori、Amiya Eisuke、Tsushima Kensuke、Adachi Takeshi、Hiroi Yukio、Funazaki Toshikazu、Komuro Issei
  • Journal Title: American Journal of Cardiovascular Drugs Volume: 18 Issue: 4 Pages: 327-332
  • DOI: 10.1007/s40256-018-0269-0
  • Peer Reviewed / Open Access
• [Journal Article] Dilated cardiomyopathy complicated with visceral heterotaxy. (2018)
  • Author(s): Tsuji M, Amiya E, Hatano M, Komuro I
  • Journal Title: Eur Heart J Volume: 39 Issue: 1 Pages: 73-73
  • DOI: 10.1093/eurheartj/ehx593
  • Peer Reviewed
• [Journal Article] Authors' reply to the Drs. Finsterer and Zarrouk-Mahjoub's comments for our case report (2018)
  • Author(s): Amiya E, Morita H, Ishiura H, Tsuji S, Komuro I.
  • Journal Title: Int J Cardiol. Volume: 254 Pages: 262-262
  • DOI: 10.1016/j.ijcard.2017.06.111
  • Peer Reviewed
• [Journal Article] Authors' response to "Compound heterozygous Fukutin mutation-related non-compaction" by Finsterer and Zarrouk-Mahjoub. (2017)
  • Author(s): Amiya E, Morita H, Ishiura H, Tsuji S, Komuro I.
  • Journal Title: Int J Cardiol Volume: Apr 15 Pages: 233-233
  • DOI: 10.1016/j.ijcard.2017.01.107
  • Peer Reviewed
• [Journal Article] ICD for Patients With Severe Renal Dysfunction (2017)
  • Author(s): Amiya E
  • Journal Title: International Heart Journal Volume: 58 Issue: 3 Pages: 303-304
  • DOI: 10.1536/ihj.17-104
  • NAID: 130006895819
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Rapid Improvement of thyroid storm-related hemodynamic collapse by aggressive anti-thyroid therapy including steroid pulse: A case report. (2017)
  • Author(s): Kiriyama H, Amiya E, Hatano M, Hosoya Y, Maki H, Nitta D, Saito A, Shiraishi Y, Minatsuki S, Sato T, Murakami H, Uehara M, Manaka K, Makita N, Watanabe M, Komuro I.
  • Journal Title: Medicine (Baltimore) Volume: 96 Issue: 22 Pages: e7053-e7053
  • DOI: 10.1097/md.0000000000007053
  • Peer Reviewed / Open Access
• [Journal Article] Newly developed atrial fibrillation progresses to a more severe INTERMACS score in a patient with advanced heart failure due to dilated cardiomyopathy. (2017)
  • Author(s): Saito A, Amiya E, Hatano M, Hosoya Y, Maki H, Nitta D, Minatsuki S, Watanabe M, Komuro I
  • Journal Title: Clin Case Rep Volume: 5 Issue: 12 Pages: 2028-2033
  • DOI: 10.1002/ccr3.1247
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly (2017)
  • Author(s): Numata G, Amiya E, Kojima T, Fujiu K, Hatano M, Watanabe M, Komuro I
  • Journal Title: International Heart Journal Volume: 58 Issue: 5 Pages: 816-819
  • DOI: 10.1536/ihj.16-580
  • NAID: 130006179198
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Presentation] 抗HLA抗体の出現と心移植後予後の関連 (2020)
  • Author(s): 網谷英介
  • Organizer: 第56回日本移植学会
• [Presentation] 二次性心筋症の診断と治療 update (2020)
  • Author(s): 網谷英介
  • Organizer: 第24回日本心不全学会
• [Presentation] Destination therapy時代のLVAD治療のリスク評価 (2020)
  • Author(s): 網谷英介
  • Organizer: 第24回日本心不全学会
• [Presentation] 左室補助人工心臓によるreverse remodeling について (2020)
  • Author(s): 網谷英介
  • Organizer: 第6回日本心筋症研究会
• [Presentation] 強心薬依存心不全患者のリハビリテーション (2020)
  • Author(s): 網谷英介
  • Organizer: 第26回日本心臓リハビリテーション学会
• [Presentation] Cardiac Rehabilitation for Dilated Cardiomyopathy (2019)
  • Author(s): 網谷英介
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] IgG４関連疾患心血管病変における心膜腔 (2019)
  • Author(s): 網谷英介
  • Organizer: 第67回日本心臓病学会
• [Presentation] 低心拍出状態の早期の検出と遅滞の介入 (2019)
  • Author(s): 網谷英介
  • Organizer: 第23回日本心不全学会
• [Presentation] 拡大基準ドナーに関するコンセンサスとその対策 (2019)
  • Author(s): 網谷英介
  • Organizer: 第55回日本移植学会
• [Presentation] 心臓移植後悪性腫瘍のリスク因子とスクリーニング法の検討 (2019)
  • Author(s): 武城千恵 網谷英介 波多野将 石田純一 牧尚孝 辻正樹 細谷弓子 遠藤美代子 今井博子 加賀美幸江 木下修 木村光利 小室一成 小野稔
  • Organizer: 第55回日本移植学会
• [Presentation] カルシニューリン阻害薬の心移植後腎機能へ与える影響 (2019)
  • Author(s): 白石泰之 網谷英介 波多野将 勝木俊臣 武城千恵 辻正樹 牧尚孝 石田純一 細谷弓子 遠藤美代子 木村光利 木下修 小野稔 小室一成
  • Organizer: 第55回日本移植学会
• [Presentation] 拡張型心筋症の心臓リハビリテーション (2019)
  • Author(s): 網谷英介
  • Organizer: 第83回日本循環器学会学術集会
  • Invited
• [Presentation] 重症心不全におけるサルコペニア・栄養・運動療法 (2018)
  • Author(s): 網谷英介
  • Organizer: 第22回日本心不全学会学術集会
  • Invited
• [Presentation] 心不全のリハビリテーションについて (2018)
  • Author(s): 網谷英介
  • Organizer: 第22回日本心不全学会学術集会 市民公開講座
  • Invited
• [Presentation] Fractional exhaled nitric oxide in adult congenital heart disease (2018)
  • Author(s): 齊藤、網谷、相馬、稲葉、牧、波多野、八尾、小室
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] high-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure (2018)
  • Author(s): 田屋、網谷、波多野、牧、新田、齊藤、辻、細谷、皆月、中山、藤原、小西、横田、渡辺、森田、芳賀、小室
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Effects of a Left Ventricular Assist Device on Endothelial Function: Comparison between LVAD models (2017)
  • Author(s): Aya Watanabe, Eisuke Amiya, Masaru Hatano, Masafumi Watanabe, Atsuko Ozeki, Daisuke Nitta, Hisataka Maki, Miyoko Endo, Yukie Kagami, Mariko Nemoto, Kan Nawata, Osamu Kinoshita, Mitsutoshi Kimura, Issei Komuro ,Minoru Ono
  • Organizer: The International Society of Mechanical Circulatory Support
  • Int'l Joint Research
• [Presentation] 心筋症の心臓リハビリテーション (2017)
  • Author(s): 網谷英介
  • Organizer: 第23回日本心臓リハビリテーション学会学術集会
  • Int'l Joint Research