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Disease susceptibility gene analysis of patients with coronary vasospasm

Research Project

Project/Area Number 17K09491
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

NAKAMURA Takamitsu  山梨大学, 大学院総合研究部, 助教 (60377512)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords冠攣縮性狭心症 / 中膜 / 内膜 / 遺伝子 / 脂質異常症 / 画像診断
Outline of Final Research Achievements

Of 164 patients with coronary artery spasm, family history of coronary artery disease was observed in 19 (11.9%) patients. Patients with family history had higher levels of ApoCIII/CII ratio, suggesting genetic factors related to dyslipidemia may contribute to susceptibility of coronary spasm, Moreover, the optical coherence tomography(OCT) and the vasomotor response to ACh were assessed in patients with previous myocardial infarction. The coronary contractile response to ACh had a positive linear relationship with medial area. The contractile response increased as the intimal layer thickened up to the inflection point; thereafter, the contractile response declined. However, there were no significant differences in risk factors and genes variable between patients with and without increased.

Academic Significance and Societal Importance of the Research Achievements

冠動脈の攣縮は、冠攣縮性狭心症のみならず種々の虚血性心疾患の病態悪化に影響を及ぼすことが知られている。しかしながら、冠攣縮を引き起こす原因については未だはっきりしていないところが多い。本研究では、冠攣縮の家族歴を有する症例では、他の冠動脈疾患のような動脈硬化危険因子は認めなかった。また、光干渉断層像(OCT)を用いた評価では、冠攣縮の病態悪化に冠動脈血管の中膜の増大が関与している可能性が示唆された。中膜増大に関与する臨床因子や遺伝因子については明らかな差は認めなかった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Improvement of Endothelial Dysfunction Is Mediated Through Reduction of Remnant Lipoprotein After Statin Therapy in Patients With Coronary Artery Disease2020

    • Author(s)
      Nakamura T, Uematsu M, Yoshizaki T, Kobayashi T, Watanabe Y, Kugiyama K.
    • Journal Title

      J Cardiol.

      Volume: 75 Issue: 3 Pages: 270-274

    • DOI

      10.1016/j.jjcc.2019.08.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship of a Thinned Medial Layer to the Attenuated Contractile Response in Atherosclerotic Coronary Arteries2020

    • Author(s)
      Nakamura T, Horikoshi T, Kugiyama K.
    • Journal Title

      Am J Physiol Heart Circ Physiol .

      Volume: 318 Issue: 1 Pages: H135-H142

    • DOI

      10.1152/ajpheart.00537.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent Dysfunction of Coronary Endothelial Vasomotor Responses is Related to Atheroma Plaque Progression in the Infarct-Related Coronary Artery of AMI Survivors2019

    • Author(s)
      Horikoshi T, Obata JE, Nakamura T, Fujioka D, Watanabe Y, Nakamura K, Watanabe K, Saito Y, Kugiyama K.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 26 Issue: 12 Pages: 1062-1074

    • DOI

      10.5551/jat.48249

    • NAID

      130007754400

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2019-12-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Remnant Lipoproteins Are Residual Risk Factor for Future Cardiovascular Events in Patients With Stable Coronary Artery Disease and On-Statin Low-Density Lipoprotein Cholesterol Levels <70 mg/dL2019

    • Author(s)
      Fujihara Y, Nakamura T, Horikoshi T, Obata JE, Fujioka D, Watanabe Y, Watanabe K, Kugiyama K.
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 6 Pages: 1302-1308

    • DOI

      10.1253/circj.CJ-19-0047

    • NAID

      130007652779

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-05-24
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary Vascular Resistance Is Associated With Brachial-Ankle Pulse-Wave Velocity and Adverse Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.2019

    • Author(s)
      Nakamura T, Uematsu M, Deyama J, Watanabe Y, Nakamura K, Kobayashi T, Saito Y, Fujioka D, Kawabata KI, Obata JE, Kugiyama K.
    • Journal Title

      J Card Fail.

      Volume: Epub ahead of print Issue: 9 Pages: 725-732

    • DOI

      10.1016/j.cardfail.2019.02.019

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High levels of stromal cell-derived factor-1α predict short-term progression of renal dysfunction in patients with coronary artery disease.2019

    • Author(s)
      Uematsu M, Nakamura T, Yoshizaki T, Watanabe Y, Deyama J, Watanabe K, Kobayashi T, Fujioka D, Saito Y, Nakamura K, Kawabata K, Obata JE, Kugiyama K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: Epub ahead of print Issue: 7 Pages: 920-927

    • DOI

      10.1007/s10157-019-01722-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of coronary artery spasm on long-term outcomes in survivors of acute myocardial infarction.2018

    • Author(s)
      Deyama J, Nakamura T, Saito Y, Obata JE, Fujioka D, Nakamura K, Watanabe K, Kugiyama K.
    • Journal Title

      Int J Cardiol.

      Volume: 257 Pages: 7-11

    • DOI

      10.1016/j.ijcard.2017.08.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Pulmonary Vascular Resistance Is Associated With Brachial-Ankle Pulse-Wave Velocity and Adverse Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.2018

    • Author(s)
      Nakamura T, Uematsu M, Deyama J, Watanabe Y, Nakamura K, Kobayashi T, Saito Y, Fujioka D, Kawabata KI, Obata JE, Kugiyama K.
    • Organizer
      American Heart Association Scientific Session 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 山梨大学第2内科ホームページ

    • URL

      https://yamanashi-2nai.com

    • Related Report
      2019 Annual Research Report
  • [Remarks] 山梨大学第2内科ホームページ

    • URL

      http://yamanashi-2nai.com

    • Related Report
      2018 Research-status Report 2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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