Research for development of gut microbial drugs for preventing cardiovascular diseases.
Project/Area Number |
17K09497
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山下 智也 神戸大学, 医学部附属病院, 准教授 (90437468)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 腸内細菌 / 冠動脈疾患 / 心不全 / 微生物製剤 / 腸内細菌叢 / 動脈硬化 / 代謝物 / バクテロイデス菌 / 抗炎症作用 |
Outline of Final Research Achievements |
We investigated the gut microbiota of coronary artery disease (CAD) patients and found that specific bacteria, Bacteroides vulgatus and dorei (2 species), were decreased in CAD patients. Oral administration of the cultured lived Bacteroides 2 species (5.0×109 cfu x5/week) to apolipoprotein E-deficient mice for 10 weeks significantly inhibited atherosclerotic lesion formation by reducing inflammatory responses, including plasma cytokine and lipopolysaccharide (LPS) levels. Taken these, we hypothesized that these bacteria could inhibit atherosclerosis in human and we would like to develop gut bacterial drugs using these Bacteroides 2 species.
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Academic Significance and Societal Importance of the Research Achievements |
循環器疾患における腸内細菌叢の調査を進め、ある疾患で特異的に変化している腸内細菌を同定した。その結果をもとに、疾患の発症や予防に関連する菌種を特定し、動物疾患モデルを使用して治療効果と作用機序を明らかにすることで腸内細菌微生物製剤候補を選出し、新規の循環器疾患治療法の開発を行っている。すでに、動脈硬化予防菌を見出し、企業との共同研究にて製剤開発を進めており、さらに心不全に対しても有効な製剤開発も達成することで社会貢献したい。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Effect of Resistant Starch on the Gut Microbiota and Its Metabolites in Patients with Coronary Artery Disease2019
Author(s)
Yoshida N, Sasaki K, Sasaki D, Yamashita T, Fukuda H, Hayashi T, Tabata T, Osawa R, Hirata K, Kondo A.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 26
Issue: 8
Pages: 705-719
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2019-08-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure2018
Author(s)
Hayashi T, Yamashita T, Watanabe H, Kami K, Yoshida N, Tabata T, Emoto T, Sasaki N, Mizoguchi T, Irino Y, Toh R, Shinohara M, Okada Y, Ogawa W, Yamada T, Hirata K.
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Journal Title
Circulation Journal
Volume: 83
Issue: 1
Pages: 182-192
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2018-12-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bacteroides vulgatus and Bacteroides dorei reduce gut microbial lipopolysachharide production and inhibit atherosclerosis.2018
Author(s)
Yoshida N, Emoto T, Yamashita T, Watanabe H, Hayashi T, Tabata T, Hoshi N, Hatano N, Sasaki N, Mizoguchi T, Amin HZ, Hirota Y, Ogawa W, Yamada T, Hirata K.
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Journal Title
Circulation.
Volume: 138
Issue: 22
Pages: 2486-2498
DOI
Related Report
Peer Reviewed
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[Journal Article] Oral administration of the lactic acid bacterium Pediococcus acidilactici attenuates atherosclerosis in mice by inducing tolerogenic dendritic cells.2017
Author(s)
Mizoguchi T, Kasahara K, Yamashita T, Sasaki N, Yodoi K, Matsumoto T, Emoto T, Hayashi T, Kitano N, Yoshida N, Amin HZ, Hirata K.
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Journal Title
Heart Vessels.
Volume: 32
Issue: 6
Pages: 768-776
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of CD14+;CD16+; monocytes on plaque vulnerability in diabetic and non-diabetic patients with asymptomatic coronary artery disease: a cross-sectional study.2017
Author(s)
Yoshida N, Yamamoto H, Shinke T, Otake H, Kuroda M, Terashita D, Takahashi H, Sakaguchi K, Hirota Y, Emoto T, Amin HZ, Mizoguchi T, Hayashi T, Sasaki N, Yamashita T, Ogawa W, Hirata K
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Journal Title
Cardio Diabet.
Volume: 16
Issue: 1
Pages: 96-96
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] UVB exposure inhibits angiotensin II-induced abdominal aortic aneurysm formation in mice by expanding CD4+Foxp3+ regulatory T cells.2017
Author(s)
Hayashi T, Sasaki N, Yamashita T, Mizoguchi T, Emoto T, AminHZ, Yodoi K, Matsumoto T, Kasahara K, Yoshida N, Tabata T, Kitano N, Fukunaga A, Nishigori T, Rikitake Y, Hirata K.
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Journal Title
J Am Heart Assoc.
Volume: 6
Issue: 9
DOI
Related Report
Peer Reviewed
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[Book] 動脈硬化診療のすべて2019
Author(s)
山下智也, 平田健一(日本医師会)
Total Pages
374
Publisher
南江堂
ISBN
9784524227556
Related Report
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