| Project/Area Number |
17K09498
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Okayama University |
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Principal Investigator |
Akagi Satoshi 岡山大学, 医歯薬学総合研究科, 助教 (60601127)
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| Co-Investigator(Kenkyū-buntansha) |
中村 一文 岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
斎藤 幸弘 岡山大学, 大学病院, 医員 (20724454)
吉田 賢司 岡山大学, 医歯薬学総合研究科, 講師 (70532761)
伊藤 浩 岡山大学, 医歯薬学総合研究科, 教授 (90446047)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 特発性肺動脈性肺高血圧症 / iPS細胞 / 心筋細胞 / エネルギー代謝 / Warburg効果 / 肺移植 / 肺動脈性肺高血圧症 |
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| Outline of Final Research Achievements |
Idiopathic pulmonary arterial hypertension (IPAH) has characteristics with remarkable elevation of pulmonary artery pressure and dysfunction of right ventricular. Drugs for IPAH targets pulmonary arteries but did not directly target right ventricle. In this study we successfully created iPS cells from fibroblast obtained from patient with IPAH. Next, we successfully induced cardiomyocyte. Cardiomyocyte from IPAH patient had characteristic that energy metabolism depends on glycolysis under both normoxia and hypoxia.
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| Academic Significance and Societal Importance of the Research Achievements |
特発性肺動脈性肺高血圧症の心筋細胞において、今回明らかになったエネルギー代謝の特性はこれまで知られていない。そのためこの特性に介入できる薬剤を開発できれば、新たな特発性肺動脈性肺高血圧症の治療薬として期待できる。
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