• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechnistic elucidation and diagnostic development of autonomic nervous system and immunity network in hypertension

Research Project

Project/Area Number 17K09508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Hirooka Yoshitaka  国際医療福祉大学, 福岡保健医療学部, 教授 (90284497)

Co-Investigator(Kenkyū-buntansha) 岸 拓弥  九州大学, 循環器病未来医療研究センター, 准教授 (70423514)
西原 正章  九州大学, 大学病院, 助教 (70641017)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords高血圧 / 脳 / 交感神経系 / レニン・アンジオテンシン系 / 炎症 / 免疫系 / 免疫 / 心臓 / アンジオテンシンII / 循環器・高血圧
Outline of Final Research Achievements

The present study determined whether activation of the sympathetic nervous system and chronic inflammation/altered immunity in the development and maintenance of hypertension. We found that changes in the hypothalamus and the brainstem in the brain as the cardiovascular center were responsible for sympathetic activation and vasopressin release. In particular, perivascular macrophages would play an important role in the development of hypertension through circulating inflammatory cytokine. We also found that renal denervation reduced the brain oxidative stress thereby inhibiting enhanced systemic sympathetic activity.

Academic Significance and Societal Importance of the Research Achievements

本研究の成績は高血圧の進展・維持における交感神経系の活性化と慢性炎症性・免疫系の変化が深く関わっていることを提示した。その機序として、血圧調節の中枢である脳内視床下部や脳幹部に循環血液中で増加している炎症細胞やサイトカインが脳内へ情報を伝える際に脳血管周囲マクロファージが重要な役割を担っていることを見いだした。また、臨床的に開発が進んでいる腎除神経の機序的な側面も明らかにした。いまだ克服されていない高血圧診断・治療における新たな展開につながることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (28 results) (of which Int'l Joint Research: 8 results,  Invited: 7 results) Book (2 results)

  • [Journal Article] 高血圧の成因2020

    • Author(s)
      廣岡良隆
    • Journal Title

      日本臨牀

      Volume: 78 Pages: 197-203

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension.2019

    • Author(s)
      Kojima H, Tokunou T, Takahara Y, Sunagawa K, Hirooka Y, Ichiki T, Tsutsui H.
    • Journal Title

      Physiological Reports

      Volume: 7 Issue: 7 Pages: e14025-e14025

    • DOI

      10.14814/phy2.14025

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prior exposure to placental ischemia causes increased salt sensitivity of blood pressure via vasopressin production and secretion in postpartum rats.2019

    • Author(s)
      Matsuura T, Shinohara K, Iyonaga T, Shibata R, Hirooka Y, Tsutsui H.
    • Journal Title

      Journal of Hypertension

      Volume: in press Issue: 8 Pages: 1657-1667

    • DOI

      10.1097/hjh.0000000000002091

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation2019

    • Author(s)
      Iyonaga Takeshi、Shinohara Keisuke、Mastuura Taku、Hirooka Yoshitaka、Tsutsui Hiroyuki
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 2 Pages: 99-110

    • DOI

      10.1038/s41440-019-0333-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧における免疫系の役割2019

    • Author(s)
      廣岡良隆
    • Journal Title

      Medical Science Digest

      Volume: 45 Pages: 690-692

    • Related Report
      2019 Annual Research Report
  • [Journal Article] High central blood pressure is associated with incident cardiovascular events in treated hypertensives: the ABC-J II Study2018

    • Author(s)
      Eguchi K, Miyashita H, Takenaka T, Tabara Y, Tomiyama H, Dohi Y, Hashimoto J, Ohkubo T, Ohta Y, Hirooka Y, Kohara K, Ito S, Kawano Y, Sunagawa K, Takazawa K, Yamashina A, Shimada K.
    • Journal Title

      Hypertension Research

      Volume: 41 Issue: 11 Pages: 947

    • DOI

      10.1038/s41440-018-0075-8

    • URL

      https://pure.teikyo.jp/en/publications/d841c02c-bfe7-41af-9758-9ac1f0a67f0f

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Olemsartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory aned aldosterone-reducing effects in hypertensive mice with chronic kidney disease.2018

    • Author(s)
      Nishihara M, Takesue K, Hirooka Y
    • Journal Title

      Clinical and Experimental Hypertension

      Volume: 40 Issue: 3 Pages: 211-219

    • DOI

      10.1080/10641963.2018.1465075

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proteinase-activated Receptor 1 Antagonism Ameliorates Experimental Pulmonary Hypertension.2018

    • Author(s)
      Kuwabara Y, Tanaka-Ishikawa M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K.
    • Journal Title

      Cardiovascular Research

      Volume: in press Issue: 8 Pages: 1357-1368

    • DOI

      10.1093/cvr/cvy284

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高血圧・心不全における交感神経活性化及び機序解明の進歩2018

    • Author(s)
      廣岡良隆
    • Journal Title

      自律神経

      Volume: 55 Pages: 1-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腎デナベーション.2018

    • Author(s)
      廣岡良隆
    • Journal Title

      Current Therapy

      Volume: 36 Pages: 77-81

    • Related Report
      2017 Research-status Report
  • [Journal Article] Arterial pressure labiality is improved by sodium-glucose cotransporter 2 inhibitor in streptozocin-induced diabetic rats.2017

    • Author(s)
      Yoshikawa T, Kishi T, Sahinohara K, Takesue K, Shibata R, Inoguchi T, Sunagawa K, Tsutsui H, Hirooka Y.
    • Journal Title

      Hypertens Res

      Volume: 印刷中 Issue: 7 Pages: 646-651

    • DOI

      10.1038/hr.2017.14

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 拡張期血圧:その規定因子,下げかた,下げ過ぎの危険.2017

    • Author(s)
      廣岡良隆
    • Journal Title

      Medical Practice

      Volume: 34 Pages: 1295-1300

    • Related Report
      2017 Research-status Report
  • [Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する.2019

    • Author(s)
      篠原啓介、彌永武史、廣岡良隆、筒井裕之
    • Organizer
      第42回日本高血圧学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高血圧における交感神経活性化:中枢性機序研究の進歩.2019

    • Author(s)
      廣岡良隆
    • Organizer
      第72回日本自律神経学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する.2019

    • Author(s)
      篠原啓介、彌永武史、松浦託、廣岡良隆、筒井裕之
    • Organizer
      第55回高血圧関連疾患モデル学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Brain perivascular macrophages contribute to the development of hypertension via sympathetic activation.2019

    • Author(s)
      Iyonaga T, Shinohara K, Matsuura T, Hirooka Y, Tsutsui H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prior exposure to preeclampsia causes increased salt-sensitivity of blood pressure in postpatum period via increased vasopressin secretion.2019

    • Author(s)
      Matsuura T, Shinohara K, Iyonaga T, Hirooka Y, Tsutsui H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Central mechanisms of hypertension: brain-heart-kidney connectio.n2019

    • Author(s)
      Hirooka Y.
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Preeclampsia induces the acquired salt-sensitivity characteristics via the increased vasopressin secretion in postpartum.2018

    • Author(s)
      Matsuura T, Shinohara K, Hirooka Y, Tsutsui H.
    • Organizer
      European Society of Cardiology Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain perivascular macrophages contribute to the development of hypertension via sympathetic activation.2018

    • Author(s)
      Iyonaga T, Shinohara K, Hirooka Y, Tsutsui H.
    • Organizer
      European Society of Cardiology Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高血圧の発症・進展と免疫系・慢性炎症の役割.2018

    • Author(s)
      廣岡 良隆.
    • Organizer
      第41回 日本高血圧学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 心不全の進展における高血圧の関与:心脳連関を含めた発症機序.2018

    • Author(s)
      篠原 啓介,柴田 理紗,廣岡 良隆,筒井 裕之.
    • Organizer
      第41回 日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 妊娠高血圧腎症の既往はバゾプレシン分泌を介して産後の食塩感受性を亢進させる.2018

    • Author(s)
      松浦 託,篠原 啓介,彌永 武史,柴田 理紗,廣岡 良隆,筒井 裕之.
    • Organizer
      第41回 日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脳血管周囲マクロファージは交感神経活性化を介して高血圧の進展に寄与する.2018

    • Author(s)
      彌永 武史,篠原 啓介,松浦 託,柴田 理紗,廣岡 良隆,筒井 裕之.
    • Organizer
      第41回 日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 急性期心不全治療の実臨床.2018

    • Author(s)
      井上 敬測,廣岡 良隆
    • Organizer
      第41回 日本高血圧学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 妊娠高血圧腎症の既往はバゾプレシン分泌亢進により産後の食塩感受性を亢進させる.2018

    • Author(s)
      松浦 託,篠原 啓介,彌永 武史,廣岡 良隆,筒井 裕之.
    • Organizer
      第54回 高血圧関連疾患モデル学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats.2018

    • Author(s)
      Iyonaga T, Shinohara K, Hirooka Y, Tsutsui H.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Preeclampsia induces acquired salt-sensitivity and increased vasopressin secretion in postpartum.2018

    • Author(s)
      Matsuura T, Shinohara K, Hirooka Y, Tsutsui H.
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inflammation and immunity in hypertension and heart failure: role of brain AT1 receptors.2018

    • Author(s)
      Hirooka Y.
    • Organizer
      The 33rd Joint Annual Conference of Biomedical Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Brain perivascular macrophages contribute to developing hypertension via sensing chronic peripheral inflammation.2017

    • Author(s)
      Iyonaga T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      Experimental Biology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduced uterine perfusion pressure-induced preeclampsia acquires salt-sensitivity characteristics in postpartum.2017

    • Author(s)
      Matsuura T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      Experimental Biology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Astrocytes play a crucial role in enhanced sympathetic outflow in heart failure.2017

    • Author(s)
      Hirooka Y.
    • Organizer
      The International Society for Autonomic Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Immunity and sympathetic nervous system in hypertension and heart failure: role of brain AT1 receptors.2017

    • Author(s)
      Hirooka Y.
    • Organizer
      The International Society for Autonomic Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Increased BDNF in NTS by activation of cardiac afferent nerves is involved in sympatoexcitation in pressure overload-induced cardiac hypertrophy.2017

    • Author(s)
      Shibata R, Shinohara K, Hirooka Y, Tsutsui H.
    • Organizer
      第21回 日本心不全学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 心脳連関から見た高血圧・心不全の病態解明と治療への応用.2017

    • Author(s)
      篠原啓介,柴田理紗,伊藤浩司,廣岡良隆,筒井裕之.
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 妊娠高血圧腎発症は産後の食塩感受性を後天的に獲得させる.2017

    • Author(s)
      松浦託,篠原啓介,筒井裕之,廣岡良隆.
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 心臓求心性交感神経活性化を介した延髄孤束核のBDNF増加が心肥大における交感神経活動亢進に関与する.2017

    • Author(s)
      柴田理紗,篠原啓介,伊藤浩司,岸拓弥,筒井裕之,廣岡良隆.
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 慢性腎臓病合併高血圧モデルマウスに対するオルメサルタンと腎除神経術併用は交感神経活動及び血中アルドステロンを抑制し強力な降圧効果を有する.2017

    • Author(s)
      西原正章,武居講,廣岡良隆.
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳血管周囲マクロファージは全身慢性炎症を感知し高血圧の発症に関与する.2017

    • Author(s)
      彌永武史,篠原啓介,筒井裕之,廣岡良隆
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] ニューロモデュレーション.2017

    • Author(s)
      廣岡良隆
    • Organizer
      第40回 日本高血圧学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 末梢循環調節.「心不全(第2版)」2018

    • Author(s)
      廣岡 良隆
    • Total Pages
      718
    • Publisher
      日本臨床社
    • Related Report
      2018 Research-status Report
  • [Book] Studies on Atherosclerosis2017

    • Author(s)
      Hirooka Y, Sunagawa K (Edited by Rodriguez-Porcel M, Chade AR, Miller JD)
    • Total Pages
      138
    • Publisher
      The Humana Press
    • ISBN
      9781489976918
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi