Intervention of Mechanisms for Residual Risk of EPA and Development of Patient Stratification Methods

• Project/Area Number: 17K09519
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Yamano Takashi 和歌山県立医科大学, 医学部, 講師 (40624151)
• Co-Investigator(Kenkyū-buntansha): 西口 毅 和歌山県立医科大学, 医学部, 博士研究員 (40549771) ; 田中 篤 和歌山県立医科大学, 医学部, 教授 (50458072)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心筋梗塞 / MMP-9 / 血糖値 / 気温 / プラーク安定化 / 炎症マーカー / エイコサペンタ塩酸 / エイコサペンタエン酸

Outline of Final Research Achievements

A randomised prospective study of ACS patients was conducted. While statins were found to contribute to early plaque stabilisation, there was no significant difference in the rate of change between the early and late statin groups for regional MMP-9, a finding that may suggest a residual risk of statins.
In addition, we found a positive correlation between blood glucose and MMP-9 levels on admission in patients with ST-elevation myocardial infarction, and that patients with intramyocardial hemorrhage, a poor prognostic factor observed on cardiac MRI, have higher blood glucose levels on admission compared to the non-hemorrhage group, as published in the paper.
We also reported that other climatic conditions may also play a role in the development of myocardial infarction, based on a study comparing myocardial infarction and climate in Thailand, where different diets, including a fish diet, were used.

Academic Significance and Societal Importance of the Research Achievements

EPAの動脈硬化への機序は不明であたため、網羅的な研究から炎症マーカーの内、局所MMP-9値を追求し、それがACSへの関与を証明した。また、入院時の血糖値が、MMP-9値の相関及び予後不良因子になることから、患者の層別化を可能にした。
さらに、平均気温が一定であるタイ国でも心筋梗塞患者の月ごとの変動が多いことを証明し、気温だけではなく、他の気候条件が心筋梗塞の層別化に有用であることを報告している。

Research Products

• [Int'l Joint Research] ブラパ大学/マヒドン大学(タイ)
• [Journal Article] 急性冠症候群発症の解明への網羅的アプローチ (2023)
  • Author(s): 山野貴司
  • Journal Title: Precision Medicine Volume: 4 Pages: 312-4
• [Journal Article] Coronary Vasospasm Complicated by Intercoronary Communication (2022)
  • Author(s): Masashi Nakamura, Takashi Yamano, Yoshinori Asae, Masahiro Takahata, Yasutsugu Shiono, Atsushi Tanaka
  • Journal Title: Circulation Journal Volume: 86 Issue: 9 Pages: 1477
  • DOI: 10.1253/circj.CJ-22-0083
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-08-25
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Atherectomy on Lesion Preparation in Heavily Calcified Coronary Artery Disease (2022)
  • Author(s): Emori Hiroki、Shiono Yasutsugu、Terada Kosei、Higashioka Daisuke、Takahata Masahiro、Fujita Suwako、Wada Teruaki、Ota Shingo、Satogami Keisuke、Kashiwagi Manabu、Kuroi Akio、Yamano Takashi、Tanimoto Takashi、Tanaka Atsushi
  • Journal Title: Circulation Reports Volume: 4 Issue: 5 Pages: 205-214
  • DOI: 10.1253/circrep.CR-22-0028
  • ISSN: 2434-0790
  • Year and Date: 2022-05-10
  • Peer Reviewed / Open Access
• [Journal Article] Hyperglycemia and intramyocardial hemorrhage in patients with ST-segment elevation myocardial infarction (2022)
  • Author(s): Ota S, Nishiguchi T, Taruya A, Tanimoto T, Ino Y, Katayama Y, Ozaki Y, Satogami K, Tanaka A
  • Journal Title: Journal of Cardiology Volume: 80 Issue: 5 Pages: 456-461
  • DOI: 10.1016/j.jjcc.2022.06.003
  • Peer Reviewed / Open Access
• [Journal Article] Telecardiology in Rural Practice: Global Trends. (2022)
  • Author(s): Yamano T, Kotani K, Kitano N, Morimoto J, Emori H, Takahata M, Fujita S, Wada T, Ota S, Satogami K, Kashiwagi M, Shiono Y, Kuroi A, Tanimoto T, Tanaka A.
  • Journal Title: nt J Environ Res Public Health Volume: 19(7) Issue: 7 Pages: 4335-4345
  • DOI: 10.3390/ijerph19074335
  • Peer Reviewed / Open Access
• [Journal Article] 形態学的アプローチから急性冠症候群のetiologyに迫る (2022)
  • Author(s): 山野貴司
  • Journal Title: Precision Medicine Volume: 13 Pages: 1224-6
• [Journal Article] 画像診断を用いた急性冠症候群の残余リスクへの評価法 (2022)
  • Author(s): 山野貴司
  • Journal Title: Precision Medicine Volume: 5 Pages: 267-269
• [Journal Article] Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–2017 (2021)
  • Author(s): Kitano Naomi, Takeuchi Takashi, Suenaga Tomohiro, Kakimoto Nobuyuki, Naka Akihiro, Shibuta Shoichi, Tachibana Shinya, Takekoshi Nobuhito, Suzuki Takayuki, Tsuchihashi Tomoya, Yamano Takashi, Akasaka Takashi, Suzuki Hiroyuki
  • Journal Title: Journal of Epidemiology Volume: 31 Issue: 2 Pages: 132-138
  • DOI: 10.2188/jea.JE20190189
  • NAID: 130007981111
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-02-05
  • Peer Reviewed / Open Access
• [Journal Article] 急性心筋梗塞の残余リスクとEPAの効果へのアプローチ (2021)
  • Author(s): 山野貴司
  • Journal Title: Bio clinica Volume: 36 Pages: 265-267
• [Journal Article] 急性冠症候群患者の残余リスクとEPAの効果へのアプローチ (2020)
  • Author(s): 山野貴司
  • Journal Title: Medical Sience Digest Volume: 11 Pages: 701-703
• [Journal Article] Lesion characteristics and prognosis of acute coronary syndrome without angiographically significant coronary artery stenosis. (2020)
  • Author(s): Taruya A, Tanaka A, Nishiguchi T, Ozaki Y, Kashiwagi M, Yamano T, Matsuo Y, Ino Y, Kitabata H, Takemoto K, Kubo T, Hozumi T, Akasaka T.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 21(2) Pages: 202-209
  • DOI: 10.1093/ehjci/jez079
  • Peer Reviewed
• [Journal Article] Feasibility and Clinical Significance of In Vivo Cholesterol Crystal Detection Using Optical Coherence Tomography. (2020)
  • Author(s): Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Matsuo Y, Kitabata H, Kubo T, Shimada E, Kondo T, Akasaka T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 40(1) Issue: 1 Pages: 220-229
  • DOI: 10.1161/atvbaha.119.312934
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative left atrial minimum volume as a surrogate marker of postoperative symptoms in senile patients with aortic stenosis who underwent surgical aortic valve replacement. (2019)
  • Author(s): Morimoto J, Hozumi T, Takemoto K, Wada T, Maniwa N, Kashiwagi M, Shimamura K, Shiono Y, Kuroi A, Yamano T, Yamaguchi T, Matsuo Y, Kitabata H, Ino Y, Kubo T, Tanaka A, Nishimura Y, Akasaka T.
  • Journal Title: J Cardiol. Volume: 74(4) Issue: 4 Pages: 366-371
  • DOI: 10.1016/j.jjcc.2019.04.003
  • Peer Reviewed / Open Access
• [Journal Article] In vivo optical coherence tomography imaging and histopathology of healed coronary plaques (2018)
  • Author(s): Shimokado Aiko、Matsuo Yoshiki、Kubo Takashi、Nishiguchi Tsuyoshi、Taruya Akira、Teraguchi Ikuko、Shiono Yasutsugu、Orii Makoto、Tanimoto Takashi、Yamano Takashi、Ino Yasushi、Hozumi Takeshi、Tanaka Atsushi、Muragaki Yasuteru、Akasaka Takashi
  • Journal Title: Atherosclerosis Volume: 275 Pages: 35-42
  • DOI: 10.1016/j.atherosclerosis.2018.05.025
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome (2017)
  • Author(s): Nishiguchi Tsuyoshi、Kubo Takashi、Tanimoto Takashi、Ino Yasushi、Matsuo Yoshiki、Yamano Takashi、Terada Kosei、Emori Hiroki、Katayama Yosuke、Taruya Akira、Ozaki Yuichi、Shiono Yasutsugu、Shimamura Kunihiro、Kameyama Takeyoshi、Kitabata Hironori、Yamaguchi Tomoyuki、Tanaka Atsushi、Hozumi Takeshi、Akasaka Takashi
  • Journal Title: JACC Cardiovasc, Img. Volume: in press Issue: 6 Pages: 829-838
  • DOI: 10.1016/j.jcmg.2017.07.011
  • Peer Reviewed / Open Access
• [Journal Article] Automated lipid-rich plaque detection with short wavelength infra-red OCT system (2017)
  • Author(s): Shimokado Aiko、Kubo Takashi、Nishiguchi Tsuyoshi、Katayama Yosuke、Taruya Akira、Ohta Shingo、Kashiwagi Manabu、Shimamura Kunihiro、Kuroi Akio、Kameyama Takeyoshi、Shiono Yasutsugu、Yamano Takashi、Matsuo Yoshiki、Kitabata Hironori、Ino Yasushi、Hozumi Takeshi、Tanaka Atsushi、Akasaka Takashi
  • Journal Title: European Heart Journal Cardiovascular Imaging Volume: in press Issue: 10 Pages: 1174-1178
  • DOI: 10.1093/ehjci/jex304
  • Peer Reviewed / Open Access
• [Journal Article] Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography (2017)
  • Author(s): Nishiguchi Tsuyoshi、Tanaka Atsushi、Taruya Akira、Ozaki Yuichi、Nakai Mai、Teraguchi Ikuko、Ota Shingo、Kuroi Akio、Kameyama Takeyoshi、Yamano Takashi、Yamaguchi Tomoyuki、Matsuo Yoshiki、Ino Yasushi、Kubo Takashi、Hozumi Takeshi、Akasaka Takashi
  • Journal Title: Jourl of Cardiology Volume: 70 Issue: 6 Pages: 524-529
  • DOI: 10.1016/j.jjcc.2017.03.009
  • Peer Reviewed / Open Access
• [Presentation] The Cost-effective Advantage of Remote Monitoring System for Patients with Arrhythmia Treatment on Rural Area (2023)
  • Author(s): 山野 貴司
  • Organizer: The 87th Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research
• [Presentation] The Cost-effective Advantage of Remote Monitoring System for Patients with Arrhythmia Treatment on Rural Area in Japan (2022)
  • Author(s): Takashi yamano
  • Organizer: 14th IEA-SEA meeting & ICPH 2022
  • Int'l Joint Research
• [Presentation] The utility of information and communication technology for arrhythmia treatment to overcome geographical accessibility. (2021)
  • Author(s): 山野貴司
  • Organizer: 第85回日本循環器学会総会 シンポジウム
• [Presentation] Risk Factors for Intestinal Bleeding in Patients Receiving Antithrombotic Therapy in the Era of Helicobacter Pylori Eradication Therapy (2018)
  • Author(s): 山野貴司、田中篤、赤阪隆史
  • Organizer: 第83回日本循環器学会学術集会