Significance of genetic mutation in pulmonary hypertension and its relationship with right ventricular failure
| Project/Area Number |
17K09525
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tokai University (2019)
Keio University (2017-2018) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 右室機能 / 肺高血圧 / 臨床心臓学 |
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| Outline of Final Research Achievements |
The carrier of bone morphogenetic protein (BMP) type II receptor (BMPR-II) mutation implicates poor prognosis in pulmonary hypertension. However, we previously reported that the prognosis after combination therapy would be better in mutation carrier than in noncarrier. In this study, an analysis of 26 cases of idiopathic pulmonary hypertension (IPAH) (7 cases with BMPR2 gene mutation positive and 19 cases with negative) showed that baseline right ventricular function was better in carrier than in noncarrier, but the right ventricular function after combination therapy was significantly better in the carrier than in the noncarrier.
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| Academic Significance and Societal Importance of the Research Achievements |
右室機能は、肺高血圧症において独立した予後規定因子であることが報告されている。しかし、治療により右室機能がどのように改善するか不明である。Bone morphogenetic protein (BMP) type II receptor (BMPR-II)遺伝子異常を有すると予後不良として知られているが、本研究では、BMPR-II遺伝子異常は薬剤による右室機能改善に影響がある可能性を示した。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Characteristics of Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension Assessed by Echocardiography in a Three-Year Observational Cohort Study2020
Author(s)
Nakayama S, Chubachi S, Sakurai K, Irie H, Tsutusmi A, Hashiguchi M, Itabashi Y, Murata M, Nakamura H, Asano K, Fukunaga K
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Journal Title
Int J Chron Obstruct Plmon Dis
Volume: 15
Pages: 487-499
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] High-sensitive cardiac troponin T level is a surrogate marker for RV functional recovery after successful balloon pulmonary angioptasty in patients with chronic thromboembolic pulmonary hypertension2018
Author(s)
Murata M, Tsugu T, Hiraide T, Moriyama H, Kimura M, Isobe S, Kawakami T, Kataoka M, Kohno T, Itabashi Y, Fukuda K
Organizer
6th World Symposium on Pulmonary Hypertension
Related Report
Int'l Joint Research
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[Presentation] The clinical value of assessing right ventricular diastolic function after balloon pulmonary angioptasty in patients with chronic thromboembolic pulmonary hypertension2018
Author(s)
Moriyama H, Murata M, Tsugu T, Kawakami T, Kataoka M, Hiraide T, Kimura M, Isobe S, Endo J, Kohno T, Itabashi Y, Fukuda K
Organizer
6th World Symposium on Pulmonary Hypertension
Related Report
Int'l Joint Research
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[Presentation] The effects of bone morphogenetic protein receptor type 2 mutation on right ventricular function in pulmonary arterial hypertension after optimal combination therapy2018
Author(s)
Hiraide T, Murata M, Kataoka M, Yuki A, Isobe S, Kawakami T, Moriyama H, Endo J, Itabashi Y, Gamou S, Fukuda K
Organizer
6th World Symposium on Pulmonary Hypertension
Related Report
Int'l Joint Research
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