Comparison of sudden cardiac death in patients admitted for acute heart failure between Japan and USA
| Project/Area Number |
17K09526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyorin University (2019-2021)
Keio University (2017-2018) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 心不全 / 突然死 / リスクモデル / 内科 |
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| Outline of Final Research Achievements |
This study sought to demonstrate the incidence of SCD in Japanese HF patients after hospitalization for acute decompensation, and externally validate the Seattle Proportional Risk Model (SPRM). We consecutively registered 2,240 acute HF patients. During the 2-year follow-up, 356 deaths (15.9%) occurred, which included 76 adjudicated SCDs (3.4%) and 280 non-SCDs. The SPRM showed acceptable discrimination (c-index=0.63; 95%CI, 0.56-0.70), similar to that of original SPRM-derivation cohort. Among HF patients with reduced ejection fraction (EF;<40%), SPRM showed improved discrimination compared to the ICD eligibility criteria (e.g. New York Heart Association functional class II-III with EF<35%): c-index=0.53 (95%CI, 0.42-0.63) vs. 0.65 (95%CI, 0.55-0.75) for SPRM.
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| Academic Significance and Societal Importance of the Research Achievements |
心不全患者の突然死予防のための植込み型除細動器(ICD)は、ガイドラインが示す適応基準に準じた使用が推奨されているが、左室駆出率 [LVEF] 35% 未満ならびにNYHA II-IIIという一次予防基準に関しては限界があることも指摘されている。SPRMのようなリスクモデルによる個別の突然死発症リスク・ICD植込みメリットの提示は、ICD使用におけるshared decision making・個別化医療の実践に繋がると期待され、今後の活用が必要と考えられる。
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Report
(6 results)
Research Products
(41 results)
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[Presentation] Effect of Multiple Comorbidities on Application of Guideline-Directed Medical Therapy in Hospitalized Heart Failure Patients2021
Author(s)
Takeuchi S, Goda A, Kohno T, Soejima K, Shiraishi Y, Saji M, Takei M, Nishita , Nakano S, Nagatomo Y, Kohsaka S, Yoshikawa T
Organizer
第85回日本循環器学会総会
Related Report
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[Presentation] Treatment Gaps in Heart Failure Patients with Malnutrition2021
Author(s)
Kawakubo Y, Shiraishi Y, Goda A, Kohno T, Nagatomo Y, Saji M, Nishihata Y, Takei M, Nakano S, Ikegami Y, Kohsaka S, Fukuda K, Yoshikawa T
Organizer
第85回日本循環器学会総会
Related Report
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[Presentation] Association with Short-acting Type vs. Long-acting Type Loop Diuretics and Long-term Clinical Outcomes in Patients Hospitalized with Acute Heart Failure2020
Author(s)
Imaeda S, Shiraishi Y, Niimi N, Goda A, Nagatomo Y, Nishihata Y, Takei M, Toyosaki Y, Kohno T, Fukuda K, Kohsaka S, Yoshikawa T. Association with
Organizer
第84回日本循環器学会総会
Related Report
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[Presentation] Sex difference in guideline directed medical therapy and its clinical impact in heart failure2020
Author(s)
Kawai A, NAGATOMO Y, GODA A, KOHNO T, TAKEI M, NISHIHATA Y, Saji M, TOYOSAKI Y, IKEGAMI Y, Shoji S, SHIRAISHI, KOHSAKA S, YOSHIKAWA T
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] The relationship between blood glucose level on admission and long-term clinical outcomes in patients with acute decompensated heart failure2020
Author(s)
Chishiiki T, NAGATOMO Y, GODA A, KOHNO T, TAKEI M, NISHIHATA Y, Saji M, TOYOSAKI Y, IKEGAMI Y, Shoji S, SHIRAISHI, KOHSAKA S, YOSHIKAWA T,
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] Association of Non-invasive Positive Pressure Ventilation Use with Tracheal Intubation and Short-term Outcome in Patients with Acute Decompensated Heart Failure2020
Author(s)
Yukino M, NAGATOMO Y, GODA A, KOHNO T, TAKEI M, NISHIHATA Y, Saji M, TOYOSAKI Y, IKEGAMI Y, Shoji S, SHIRAISHI, KOHSAKA S, YOSHIKAWA T
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] Gaps in Provision of Guideline-Based Medical Therapy in Hospitalized Heart Failure with Malnutrition: A Report from the WET-HF registry2020
Author(s)
Kawakubo Y, SHIRAISHI, GODA A, NAGATOMO Y, NISHIHATA Y, SAJI M, TAKEI M, TOYOSAKI Y, IKEGAMI Y, SHOJI S, KOHNO T, FUKUDA K, KOHSAKA S, YOSHIKAWA T
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] Alteration in Diuretic Strategy after an Update on the Clinical Practice Guideline Recommendations for Acute Heart Failure Management in Japan2020
Author(s)
Yamazaki Y, SHIRAISHI, KOHSAKA S, GODA A, NAGATOMO Y, NISHIHATA Y, Sachi M, TAKEI M, TOYOSAKI Y, IKEGAMI Y, KOHNO T, FUKUDA K, YOSHIKAWA T,
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] Association of Short-Acting Versus Long-Acting Loop Diuretics With Long-term Outcomes in Patients Hospitalized for Acute Heart Failure2020
Author(s)
IMAEDA S, SHIRAISHI ,NIIMI N, GODA A, NAGATOMO Y, NISHIHATA Y, TAKEI M, TOYOSAKI Y, IKEGAMI Y, KOHNO T, FUKUDA K, KOHSAKA S, YOSHIKAWA T,
Organizer
第24回日本心不全学会学術集会
Related Report
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[Presentation] Incidence and Prediction of Sudden Cardiac Death among Heart Failure Patients: Collaborative Study of WET-HF Registry and University of Washington2019
Author(s)
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas RF, Levy W.
Organizer
第83回日本循環器学会総会
Related Report
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[Presentation] Predicting Sudden Cardiac Death in Japanese Heart Failure Patients: International Validation of Seattle Proportional Risk Model.2018
Author(s)
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas RF, Levy W.
Organizer
European Society of Cardiology Congress 2018
Related Report
Int'l Joint Research
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[Presentation] Decline in Serum Potassium during Hospitalization and Its Impact of Post-Discharge Clinical Outcomes in Patients with Acute Heart Failure2018
Author(s)
214.Moriyama H, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Nagatomo Y, Goda A, Mizuno A, Nagatomo Y, Sujino Y, Fukuda K, Yoshikawa T.
Organizer
第78回日本循環器学会総会
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