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Monitoring of cancer therapeutics-related cardiac dysfunction with echocardiography and cardiac biomarkers in patients with gastric cancer

Research Project

Project/Area Number 17K09540
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

WATANABE Atai  公益財団法人がん研究会, 有明病院 総合診療部, 副医長 (00597271)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords薬剤性心筋症 / トラスツズマブ / 胃がん / 循環器・高血圧 / 癌
Outline of Final Research Achievements

The purpose of this study is to determine the relationships between echocardiographic and clinical parameters and cancer therapeutics-related cardiac dysfunction (CTRCD) in patients with gastric cancer received chemotherapy with/without trastuzumab (Tras).
Of the 51 patients, 4 (7.8%) developed CTRCD (3 with Tras (12.5%) vs 1 without Tras (3.7%)). With Tras, change of left ventricular ejection fraction (LVEF) was decreased as compared with that of control group. (Tras group -6.0% vs control group 1.5%, P=0.001). Medical history of heart diseases, larger left ventricular (LV) dimension and lower LVEF were associated with development of CTRCD in Tras group (P<0.05 for all).
Cardiac toxicity of Tras has been evaluated in breast cancer patients. In this study, a similar LVEF decline was observed in patients with gastric cancer. Furthermore, a lower systolic function of LV was predictive of CTRCD. Our findings may suggest a strategy to identify high-risk patients prior to Tras therapy.

Academic Significance and Societal Importance of the Research Achievements

これまで、トラスツズマブの心毒性に関する研究は、主に対象患者数の多い乳がん患者で行われており、胃がんでの検討は少ない。胃がん患者では、乳がん患者に比べ、基礎疾患の罹患率が高い高齢者が多い。一方、アントラサイクリン系薬剤との併用投与は行われない。今回の検討で、胃がんにおいても、乳がん患者での報告と同程度の左室駆出率の低下が示された。また、トラスツズマブ投与群において、治療開始前に、心疾患の既往があり、左室収縮指標が低下傾向を示す症例は、薬剤性心筋症を高率に発症する可能性が示唆された。本研究は、胃がん患者におけるトラスツズマブの心毒性の事前予測や早期診断のための判断基準のひとつとなる可能性がある。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] 進行卵巣癌に合併した静脈血栓塞栓症の治療中に発生したヘパリン起因性血小板減少症に抗トロンビン薬から直接経口抗凝固薬への移行可能であった一症例2021

    • Author(s)
      渡邉直、保田知生、岡本幸太、中林誠、野村秀高、竹島信宏、中山耕之介
    • Journal Title

      心臓

      Volume: -

    • Related Report
      2020 Research-status Report
  • [Journal Article] Echocardiographic Predictors of Cancer Therapeutics-Related Cardiac Dysfunction in Patients with Hematologic Malignancies2019

    • Author(s)
      Atai Watanabe, Naohide Yamashita, Toyotaka Kawamata, Kazuaki Yokoyama, Takaaki Konuma, Seiko Kato, Nobuhiro Ohno, Satoshi Takahashi, Kaoru Uchimaru, Arinobu Tojo
    • Journal Title

      Advances in Clinical and Translational Research

      Volume: 3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of personal genomic testing for disease-prevention behavior when combined with careful consultation with a physician: a preliminary study.2018

    • Author(s)
      Hayashi M, Watanabe A, Muramatsu M, Yamashita N
    • Journal Title

      BMC Res Notes.

      Volume: 11 Issue: 1 Pages: 2018-2018

    • DOI

      10.1186/s13104-018-3330-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 臨床における全ゲノム解析の有用性2018

    • Author(s)
      山下直秀, 村松正明, 林幹浩, 渡邉直, 田口淳一, 堀尾留里子, 飴谷章夫, 小島直樹, 金田俊介
    • Journal Title

      臨床医薬

      Volume: 34 Pages: 567-577

    • Related Report
      2018 Research-status Report
  • [Journal Article] Reversible Pulmonary Arterial Hypertension Induced by Dasatinib in a Patient with Chronic Myeloid Leukemia.2017

    • Author(s)
      Atai Watanabe, Kazuaki Yokoyama, Nobuhiro Ohno, Kaoru Uchimaru, Naohide Yamashita, Arinobu Tojo.
    • Journal Title

      Journal of Diagnostic Medical Sonography

      Volume: 33 Issue: 4 Pages: 284-289

    • DOI

      10.1177/8756479317697945

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 進行卵巣癌に合併した静脈血栓塞栓症の治療中に発生したヘパリン起因性血小板減少症に抗トロンビン薬から直接経口抗凝固薬への移行可能であった一症例2020

    • Author(s)
      渡邉直、保田知生、岡本幸太、中林誠、野村秀高、竹島信宏、中山耕之介
    • Organizer
      第27回肺塞栓症研究会・学術集会
    • Related Report
      2020 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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