Detection of cholesterol crystals in plaques and elucidation of pathological role using in vivo imaging tool

• Project/Area Number: 17K09557
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Katayama Yosuke 和歌山県立医科大学, 医学部, 学内助教 (10714214)
• Co-Investigator(Kenkyū-buntansha): 田中 篤 和歌山県立医科大学, 医学部, 准教授 (50458072)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 急性心筋梗塞 / コレステロール結晶 / 光干渉断層法 / プラーク破裂 / plaque rupture / 動脈硬化

Outline of Final Research Achievements

In this study, we found that optical coherence tomography(OCT) has a high specificity and modest sensitivity for the detection of cholesterol crystals when compared with those achieved using histologyCholesterol crystallization invading a fibrous cap is frequently associated with plaque ruptures and subsequent acute myocardial infractions. The combination of cholesterol crystals invading fibrous cap and thin-cap fibroatheromas detected by OCT may better identify rupture-prone plaques.

Academic Significance and Societal Importance of the Research Achievements

本研究の意義はコレステロール結晶が①プラーク進展・不安定化の新たなマーカーとして、②新たな治療ターゲットとして、③プラークの退縮・安定化のサロゲートマーカーとして利用できる可能性がある点である。

Research Products

• [Journal Article] Feasibility and Clinical Significance of In Vivo Cholesterol Crystal Detection Using Optical Coherence Tomography. (2020)
  • Author(s): Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Matsuo Y, Kitabata H, Kubo T, Shimada E, Kondo T, Akasaka T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 40(1) Issue: 1 Pages: 220-229
  • DOI: 10.1161/atvbaha.119.312934
  • Peer Reviewed / Open Access
• [Journal Article] The relationship between timing of prasugrel pretreatment and in-stent thrombus immediately after percutaneous coronary intervention for acute coronary syndrome: an optical coherence tomography study. (2018)
  • Author(s): Katayama Y, Kubo T, Ino Y, Kameyama T, Matsuo Y, Kitabata H, Terada K, Emori H, Aoki H, Taruya A, Shimamura K, Ota S, Tanaka A, Hozumi T, Akasaka T.
  • Journal Title: Heart and Vessels. Volume: 33 Issue: 10 Pages: 1159-1167
  • DOI: 10.1007/s00380-018-1167-8
  • Peer Reviewed / Open Access
• [Journal Article] Two-year vascular responses to drug-eluting stents with biodegradable polymer versus durable polymer: An optical coherence tomography sub-study of the NEXT (2017)
  • Author(s): Katayama Yosuke、Kubo Takashi、Akasaka Takashi、Ino Yasushi、Kimura Kazuo、Okura Hiroyuki、Shinke Toshiro、Igarashi Keiichi、Kadota Kazushige、Kozuma Ken、Tanabe Kengo、Nakagawa Yoshihisa、Muramatsu Toshiya、Morino Yoshihiro、Kimura Takeshi
  • Journal Title: Journal of Cardiology Volume: 70 Issue: 6 Pages: 530-536
  • DOI: 10.1016/j.jjcc.2017.04.005
  • Peer Reviewed
• [Presentation] 3.Cholesterol crystals in superficial plaque layer detected by optical coherence tomography as a new morphological feature for plaque rupture. (2019)
  • Author(s): Yosuke Katayama
  • Organizer: European Society of Cardiology
  • Int'l Joint Research
• [Presentation] 4.Cholesterol crystal penetrating fibrous cap as a new independent predictor for plaque rupture. (2019)
  • Author(s): Yosuke Katayama
  • Organizer: American College of Cardiology
  • Int'l Joint Research
• [Presentation] 2.Detection Ability of Optical Coherence Tomography for Cholesterol Crystal: Histopathological Validation Study. (2019)
  • Author(s): Yosuke Katayama
  • Organizer: Transcatheter Cardiovascular Therapeutics
  • Int'l Joint Research
• [Presentation] 5.In vivo Cholesterol Crystal Detected by Optical Coherence Tomography as a New Morphological Feature for Plaque Rupture. (2019)
  • Author(s): 片山 陽介
  • Organizer: 日本循環器学会総会
• [Presentation] Cholesterol crystal penetrating fibrous cap as a new independent predictor for plaque rupture. (2019)
  • Author(s): Yosuke Katayama
  • Organizer: ACC2019
  • Int'l Joint Research
• [Presentation] Cholesterol crystals in superficial plaque layer detected by optical coherence tomography as a new morphological feature for plaque rupture (2019)
  • Author(s): Yosuke Katayama
  • Organizer: ESC2019
  • Int'l Joint Research
• [Presentation] Association between Cholesterol Crystals Piercing Fibrous Cap and Plaque Rupture in Patients with Acute Coronary Syndrome (2018)
  • Author(s): Yosuke Katayama
  • Organizer: ESC2018
  • Int'l Joint Research