Establishment of strategy to identify high-risk coronary plaques by non-invasive multi-imagings

• Project/Area Number: 17K09566
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Yasuhide Asaumi 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20629315)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 冠動脈硬化 / 病理学 / 放射線診断学 / 冠動脈硬化症 / 核磁気共鳴画像法 / 臨床病理学 / 高リスク冠動脈硬化巣 / 病理 / 循環器

Outline of Final Research Achievements

Non-contrast T1-weighted nuclear magnetic resonance imaging (T1WI) to evaluate coronary atherosclerosis, which does not require contrast media, is expected to be a screening technique in the future. Thus, we conducted this study to establish a method for highly accurate diagnosis, and guidances for various medical treatments, method, and to elucidate the molecular pathogenesis and novel therapeutic targets for atherosclerosis. We have been working on the pathological significance of high-signal visualized coronary plaque on T1WI, which is directly related to future coronary events, and on the automation of its quantification. As a result, we reported that high-signal coronary plaques consist of higher lipid component and have a large plaque volume, and that a three-dimensional semi-automated coronary plaque assessment using a commercial software could predict subsequent coronary events more accurately.

Academic Significance and Societal Importance of the Research Achievements

若年者の冠動脈疾患発症はその後の多くの介入が必要となるため、未然に発症を予防する・予知する低侵襲的手法の開発が求められている。近年、造影X線冠動脈CTを用いた動脈硬化の解剖学的情報を知ることがその後の冠動脈疾患発症リスクを軽減させることが報告されている。すなわち冠動脈硬化の解剖学的情報を知ることがその後の新たな介入が可能となり、予後を改善させることができるという期待が持たれている。この核磁気共鳴画像法を用いた冠動脈硬化の解剖学的評価法は、全く造影剤を用いることがないことから、スクリーニング法として予後を改善させることが期待されることから、技術的発展が益々望まれる分野である。

Research Products

• [Journal Article] COVID-19 pandemic is associated with mechanical complications in patients with ST-elevation myocardial infarction (2021)
  • Author(s): Kitahara S, Fujino M, Honda S, Asaumi Y, Kataoka Y, Otsuka F, Nakanishi M, Tahara Y, Ogata S, Onozuka D, Nishimura K, Fujita T, Tsujita K, Ogawa H, Noguchi T.
  • Journal Title: Open Heart Volume: 8 Issue: 1 Pages: e001497-e001497
  • DOI: 10.1136/openhrt-2020-001497
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac outcomes in patients with acute coronary syndrome attributable to calcified nodule (2021)
  • Author(s): Sugane Hiroki、Kataoka Yu、Otsuka Fumiyuki、Nakaoku Yuriko、Nishimura Kunihiro、Nakano Hiroki、Murai Kota、Honda Satoshi、Hosoda Hayato、Matama Hideo、Doi Takahito、Nakashima Takahiro、Fujino Masashi、Nakao Kazuhiro、Yoneda Shuichi、Tahara Yoshio、Asaumi Yasuhide、Noguchi Teruo、Kawai Kazuya、Yasuda Satoshi
  • Journal Title: Atherosclerosis Volume: 318 Pages: 70-75
  • DOI: 10.1016/j.atherosclerosis.2020.11.005
  • Peer Reviewed / Open Access
• [Journal Article] Predicting Parameters for Successful Weaning from Veno‐Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock (2020)
  • Author(s): Sawada Kenichiro、Kawakami Shoji、Murata Shunsuke、Nishimura Kunihiro、Tahara Yoshio、Hosoda Hayato、Nakashima Takahiro、Kataoka Yu、Asaumi Yasuhide、Noguchi Teruo、Sugimachi Masaru、Fujita Tomoyuki、Kobayashi Junjiro、Yasuda Satoshi
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 1 Pages: 471-480
  • DOI: 10.1002/ehf2.13097
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Mortality Prediction Models on Long-Term Mortality in Hospitalized Patients With Acute Heart Failure ― The Importance of Accounting for Nutritional Status ― (2019)
  • Author(s): Nakano H、Omote K、Nagai T、Nakai M、Nishimura K、Honda Y、Honda S、Iwakami N、Sugano Y、Asaumi Y、Aiba T、Noguchi T、Kusano K、Yokoyama H、Yasuda S、Ogawa H、Chikamori T、Anzai T、on behalf of the NaDEF Investigators
  • Journal Title: Circulation Journal Volume: 83 Issue: 3 Pages: 614-621
  • DOI: 10.1253/circj.CJ-18-1243
  • NAID: 130007604358
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-02-25
  • Peer Reviewed
• [Journal Article] Rationale, design, and baseline characteristics of the prospective Japan Acute Myocardial Infarction Registry (JAMIR). (2019)
  • Author(s): Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR investigators.
  • Journal Title: Cardiovascular Drugs and Therapy Volume: 33 Issue: 1 Pages: 97-103
  • DOI: 10.1007/s10557-018-6839-1
  • Peer Reviewed
• [Journal Article] Clinical Usefulness of an Echo-Doppler Model in Predicting Elevated Pulmonary Capillary Wedge Pressure in Patients With Heart Failure (2019)
  • Author(s): Chinen D、Nagai T、Uemura K、Aikawa Y、Motokawa T、Asaumi Y、Ogo T、Kanzaki H、Noguchi T、Anzai T、Shimizu W、Ogawa H、Sugimachi M、Yasuda S
  • Journal Title: The American Journal of Cardiology Volume: 123 Issue: 9 Pages: 1464-1469
  • DOI: 10.1016/j.amjcard.2019.01.053
  • Peer Reviewed
• [Journal Article] Clinical impact of native T1 mapping for detecting myocardial impairment in takotsubo cardiomyopathy (2019)
  • Author(s): Aikawa Yukio、Noguchi Teruo、Morita Yoshiaki、Tateishi Emi、Kono Atsushi、Miura Hiroyuki、Komori Yoshiaki、Asaumi Yasuhide、Fukuda Tetsuya、Yasuda Satoshi
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: 0 Issue: 10 Pages: 0-0
  • DOI: 10.1093/ehjci/jez034
  • Peer Reviewed
• [Journal Article] Successful Transcatheter Atrial Septal Defect Closure Prior to Coronary Artery Bypass Grafting Using Anti-Congestive Therapies and Intraaortic Balloon Pumping in a Patient with Severe Ischemic Cardiomyopathy and Triple-Vessel Coronary Artery Disease (2018)
  • Author(s): Konagai Nao、Fukui Shigefumi、Kitano Masataka、Asaumi Yasuhide、Nakanishi Michio、Ogo Takeshi、Fujita Tomoyuki、Ohnishi Yoshihiko、Kobayashi Junjiro、Yasuda Satoshi
  • Journal Title: International Heart Journal Volume: 59 Issue: 6 Pages: 1480-1484
  • DOI: 10.1536/ihj.17-563
  • NAID: 130007521864
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-11-30
  • Peer Reviewed
• [Journal Article] Optical coherence tomography-verified morphological correlates of high-intensity coronary plaques on non-contrast T1-weighted magnetic resonance imaging in patients with stable coronary artery disease. (2018)
  • Author(s): Kanaya T, Noguchi T, Otsuka F, Asaumi Y, Kataoka Y, Morita Y, Miura H, Nakao K, Fujino M, Kawasaki T, Nishimura K, Inoue T, Narula J, Yasuda S.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 00 Issue: 1 Pages: 1-1
  • DOI: 10.1093/ehjci/jey035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Marking Technique for Identification of Optimal Stent Landing Site With Optical?Coherence Tomographic Imaging (2018)
  • Author(s): Nakamura Yuichi、Kataoka Yu、Asaumi Yasuhide、Noguchi Teruo、Yasuda Satoshi
  • Journal Title: JACC: Cardiovascular Interventions Volume: 11 Issue: 10 Pages: e79-e80
  • DOI: 10.1016/j.jcin.2018.03.012
  • Peer Reviewed
• [Journal Article] Comparison of Long-Term Mortality in Patients With Previous Coronary Artery Bypass Grafting Who Underwent Percutaneous Coronary Intervention With Versus Without Optimal Medical Therapy (2018)
  • Author(s): Nakamura Yuichi、Asaumi Yasuhide、Miyagi Tadayoshi、Nakai Michikazu、Nishimura Kunihiro、Sugane Hiroki、Matama Hideo、Kataoka Yu、Miyamoto Yoshihiro、Takeishi Yasuchika、Noguchi Teruo、Yasuda Satoshi
  • Journal Title: The American Journal of Cardiology Volume: 122 Issue: 2 Pages: 206-212
  • DOI: 10.1016/j.amjcard.2018.04.009
  • Peer Reviewed / Open Access
• [Journal Article] Clinical determinants of successful weaning from extracorporeal membrane oxygenation in patients with fulminant myocarditis (2018)
  • Author(s): Matsumoto M、Asaumi Y、Nakamura Y、Nakatani T、Nagai T、Kanaya T、Kawakami S、Honda S、Kataoka Y、Nakajima S、Seguchi O、Yanase M、Nishimura K、Miyamoto Y、Kusano K、Anzai T、Noguchi T、Fujita T、Kobayashi J、Ishibashi-Ueda H、Shimokawa H、Yasuda S
  • Journal Title: ESC Heart Failure Volume: 5 Issue: 4 Pages: 675-684
  • DOI: 10.1002/ehf2.12291
  • Peer Reviewed
• [Journal Article] Elevated Plasma D-Dimer Level Is Associated With Short-Term Risk of Ischemic Stroke in Patients With Acute Heart Failure (2018)
  • Author(s): Hamatani Y、Nagai T、Nakai M、Nishimura K、Honda Y、Nakano H、Honda S、Iwakami N、Sugano Y、Asaumi Y、Aiba T、Noguchi T、Kusano K、Toyoda K、Yasuda S、Yokoyama H、Ogawa H、Anzai T、on behalf of the NaDEF Investigators
  • Journal Title: Stroke Volume: 49 Issue: 7 Pages: 1737-1740
  • DOI: 10.1161/strokeaha.118.021899
  • Peer Reviewed
• [Journal Article] Effect of eicosapentaenoic acid/docosahexaenoic acid on coronary high-intensity plaques detected with non-contrast T1-weighted imaging (the AQUAMARINE EPA/DHA study): study protocol for a randomized controlled trial. (2018)
  • Author(s): Nakao K, Noguchi T, Asaumi Y, Morita Y, Kanaya T, et al.
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s13063-017-2353-1
  • Peer Reviewed / Open Access
• [Journal Article] Noninvasive Coronary Plaque Imaging (2018)
  • Author(s): Noguchi T, Nakao K, Asaumi Y, Morita Y, Otsuka F, Kataoka Y, Hosoda H, Miura H, Fukuda T, Yasuda S
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 4 Pages: 281-293
  • DOI: 10.5551/jat.RV17019
  • NAID: 130006602384
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction. (2018)
  • Author(s): Maniwa N, Fujino M, Nakai M, Nishimura K, Miyamoto Y, Kataoka Y, Asaumi Y, Tahara Y, Nakanishi M, Anzai T, Kusano K, Akasaka T, Goto Y, Noguchi T, Yasuda S.
  • Journal Title: European Heart Journal Volume: 39 Issue: 3 Pages: 201-208
  • DOI: 10.1093/eurheartj/ehx551
  • Peer Reviewed
• [Journal Article] Coronary Artery Ectasia Predicts Future Cardiac Events in Patients With Acute Myocardial Infarction. (2017)
  • Author(s): Doi T, Kataoka Y, Noguchi T, Shibata T, Nakashima T, Kawakami S, Nakao K, Fujino M, Nagai T, Kanaya T, Tahara Y, Asaumi Y, Tsuda E, Nakai M, Nishimura K, Anzai T, Kusano K, Shimokawa H, Goto Y, Yasuda S.
  • Journal Title: Arteriosclerosis, Thrombosis and Vascular Biology. Volume: 37 Issue: 12 Pages: 2350-2355
  • DOI: 10.1161/atvbaha.117.309683
  • Peer Reviewed / Open Access
• [Presentation] Development of artificial intelligence-based risk stratification of coronary magnetic resonance imaging for patients with coronary artery disease. (2021)
  • Author(s): 浅海泰栄
  • Organizer: 第85回日本循環器学会学術総会 特別企画3.循環器画像診断におけるAI活用の最前線.
• [Presentation] 心原性ショック合併非保護左主幹部急性心筋梗塞に対する冠血行再建術の戦略: 当院の治療成績からの考察. (2021)
  • Author(s): 浅海泰栄
  • Organizer: 第29回日本心血管カテーテルインターベンション治療学会総会 シンポジウム1. 心肺停止蘇生後の急性心筋梗塞治療戦略.
• [Presentation] An artificial intelligence approach for risk stratification from coronary T1 weighted imaging in patients with coronary artery disease. (2020)
  • Author(s): 浅海泰栄
  • Organizer: 第84回日本循環器学会学術総会 シンポジウム22. 循環器疾患のAI画像診断.
• [Presentation] Histological Tissue Characterization Of Coronary High Intensity Plaques On Non-contrast T1 Weighted Magnetic Resonance Imaging In Patients With Cardiovascular Diseases: An Ex-vivo Study (2019)
  • Author(s): Yasuhide Asaumi , Teruo Noguchi , Yoshiaki Morita , Fumiyuki Otsuka , Taka-aki Matsuyama , Kazuhiro Nakao , Yu Kataoka , Hatsue Ishibashi-Ueda , Satoshi Yasuda
  • Organizer: The American Heart Association's 2019 Scientific Sessions
  • Int'l Joint Research
• [Presentation] Tissue characterization of high-risk coronary plaques detected on non-invasive magnetic resonance imaging: comparison with histological findings and their fundamental roles. (2019)
  • Author(s): Yasuhide Asaumi
  • Organizer: 第82回日本循環器学会総会
• [Presentation] Abstract 16072: Clinical Significance of 3-Dimensional Assessment of Coronary High-Intensity Plaques With T1-Weighted Magnetic Resonance as a Predictor of Periprocedual Myocardial Injury During Percutaneous Coronary Intervention. (2017)
  • Author(s): Hayato Hosoda, Yasuhide Asaumi, Teruo Noguchi, Yoshiaki Morita, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Kazuhiro Nakao, Fumiyuki Otsuka, Kensaku Nishihira, Yu Kataoka, Michikazu Nakai, Kunihiro Nishimura, Hisao Ogawa and Satoshi Yasuda
  • Organizer: 2017年11月 American Heart Association Scientific Meeting
  • Int'l Joint Research
• [Presentation] Utility of High Risk Patients Detected by Cardiac Magnetic Resonance Adding on Risk Score Improves the Predictive Value of Future Coronary Event in Subjects Without Coronary Artery Disease (2017)
  • Author(s): Kazuhiro Nakao, Teruo Noguchi, Yasuhide Asaumi, Yoshiaki Morita, Kunihiro Nishimura, Michikazu Nakai, Yoshihiro Miyamoto, Tomohiro Kawasaki and Satohi Yasuda
  • Organizer: 2017年11月 American Heart Association Scientific Meeting
  • Int'l Joint Research
• [Presentation] Diastolic-toSystolic Flow Velocity Ratio as a Potential Measure to Predict Future Coronary Revascularization Despite Normal Coronary Flow Reserve: Analysis From Transthoracic Doppler Echocardiography (2017)
  • Author(s): Hayato Nakamura, Yu Kataoka, Yasuyuki Honda, Yasuhide Asaumi, Hideaki Kanzaki, Teruo Noguchi, Toshihisa Anzai and Satoshi Yasuda
  • Organizer: 2017年11月 American Heart Association Scientific Meeting
  • Int'l Joint Research
• [Presentation] The Impact of Neurogenic Stunned Myocardium on Cardiovascular Events During Hospitalization in Patients With Acute Ischemic Stroke (2017)
  • Author(s): Kaho Shibata, Takahiro Nakashima, Shoji Kawakami, Kazuhiro Nakao, Fumiyuki Otsuka, Masashi Fujino, Kensaku Nishihira, Tetsuo Arakawa, Yoshio Tahara, Yu Kataoka, Yasuhide Asaumi, Teruo Noguchi, Satoshi Yasuda, Tomotaka Tanaka, Masafumi Ihara and Kazunori Toyoda
  • Organizer: 2017年11月 American Heart Association Scientific Meeting
  • Int'l Joint Research
• [Presentation] Cholesterol Crystal as an Important Contributor to Plaque Instability in Type2 Diabetic Patients With Coronary Artery Disease: Insights From Optical Coherence Tomography Imaging Analysis (2017)
  • Author(s): Hiroki Nakano, Yu Kataoka, Shunsuke Usami, Takahiro Nakashima, Shoji Kawakami, Masashi Fujino, Kazuhiro Nakao, Shuichi Yoneda, Fumiyuki Otsuka, Kensaku Nishihira, Yoshio Tahara, Yasuhide Asaumi, Teruo Noguchi and Satoshi Yasuda
  • Organizer: 2017年11月 American Heart Association Scientific Meeting
  • Int'l Joint Research
• [Presentation] Optimal Medical Treatment in Post Coronary Artery Bypass Grafting Patients Undergoing Percutaneous Coronary Intervention as a Secondary Coronary Revascularization (2017)
  • Author(s): Yuichi Nakamura, Yasuhide Asaumi, Hiroki Sugane, Hideo Matama, Takahiro Nakashima Shoji Kawakami, Toshiyuki Nagai, Kazuhiro Nakao, Kensaku Nishihira, Fumiyuki Otsuka, Yu Kataoka, Satoshi Yasuda
  • Organizer: 2018年3月22日 日本循環器学会総会