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Pathophysiological significance of mechanisms underlying metabolic remodeling of hypertrophied heart

Research Project

Project/Area Number 17K09568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionGunma University

Principal Investigator

Iso Tatsuya  群馬大学, 大学院医学系研究科, 研究員 (10400756)

Co-Investigator(Kenkyū-buntansha) 大日方 英  群馬大学, 大学院医学系研究科, 准教授 (50332557)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心肥大 / 構造リモデリング / 代謝リモデリング / 脂肪酸代謝 / グルコース代謝 / 心不全 / 脂肪酸 / グルコース
Outline of Final Research Achievements

Under increased workload, the heart shows structural (cardiac hypertrophy
and fibrosis) and metabolic remodeling. However, little was unknown about a link between structural and metabolic remodeling. FABP4/5 double knockout and CD36 knockout mice exhibit reduced fatty acid (FA) use with a marked increase in glucose uptake in hearts. When hearts were pressure-overloaded, cardiac dysfunction was exacerbated in both mice. Metabolic analysis revealed that total energy supply was reduced despite a further increase in glucose uptake, leading to a reduction in ATP synthesis. In contrast, de novo synthesis of biomaterials for cardiac hypertrophy (i.e. amino acids and nucleic acids) was facilitated. Synthesis of glycerophospholipid, a component of membrane structure, was likely to depend on exogenous FA uptake. Thus, the heart favors anabolic reactions rather than ATP synthesis during the development of cardiac hypertrophy even under conditions where total energy supply is limited.

Academic Significance and Societal Importance of the Research Achievements

心臓のエネルギー代謝をATP産生経路と非ATP産生経路の両面から、全体像を俯瞰してin vivo実験を重ねることで、心肥大形成の際のアミノ酸・脂肪酸・核酸の生合成の問題点に到達した。心機能の維持にとって、心筋細胞の収縮連関に直接関与するATP産生以外にも、組織構築の維持や補強に必須の生体分子の生合成が重要な役割をはたすことを明らかにした意義は大きい。また、従来のランゲンドルフ還流心(ex vivo実験)では得られない実験結果を、in vivo実験で提示できた点は特筆に値する。In vivo心筋の代謝変化の全体像を理解することで、心不全治療開発戦略の包括的なアプローチを促進するものと考える。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (52 results)

All 2020 2019 2018 2017 Other

All Journal Article (13 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (33 results) (of which Int'l Joint Research: 7 results) Book (1 results) Remarks (5 results)

  • [Journal Article] 心筋エネルギー基質変換の病態生理的意義2020

    • Author(s)
      磯達也
    • Journal Title

      心臓

      Volume: 52(2) Pages: 201-209

    • NAID

      130008028574

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts2019

    • Author(s)
      Sunaga Hiroaki、Koitabashi Norimichi、Iso Tatsuya、Matsui Hiroki、Obokata Masaru、Kawakami Ryo、Murakami Masami、Yokoyama Tomoyuki、Kurabayashi Masahiko
    • Journal Title

      Scientific Reports

      Volume: 9(1) Issue: 1 Pages: 11841-11841

    • DOI

      10.1038/s41598-019-48356-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exercise endurance capacity ismarkedly reduced due to impaired energy homeostasis during prolonged fasting inFABP4/5 deficient mice.2019

    • Author(s)
      Iso T, Haruyama H, Sunaga H, Matsui M, Matsui H, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Yokoyama T, Kurabayashi M.
    • Journal Title

      BMC Physiol.

      Volume: 19(1) Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12899-019-0038-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心臓エネルギー代謝と圧負荷ストレス応答2019

    • Author(s)
      磯達也
    • Journal Title

      循環器内科

      Volume: 85(3) Pages: 312-319

    • Related Report
      2018 Research-status Report
  • [Journal Article] Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice2018

    • Author(s)
      Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H.
    • Journal Title

      Hypertension

      Volume: 72(6) Issue: 6 Pages: 1355-1364

    • DOI

      10.1161/hypertensionaha.118.11316

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption2018

    • Author(s)
      Shrestha S, Sunaga H, Hanaoka H, Yamaguchi A, Kuwahara S, Umbarawan Y, Nakajima K, Machida T, Murakami M, Saito A, Tsushima Y, Kurabayashi M, Iso T
    • Journal Title

      Sci Rep

      Volume: 8(1) Issue: 1 Pages: 16451-16451

    • DOI

      10.1038/s41598-018-34902-w

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting2018

    • Author(s)
      Iso T, Haruyama H, Sunaga H, Matsui H, Matsui M, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Putri M, Yamaguchi A, Hanaoka H, Negishi K, Yokoyama T, Kurabayashi M
    • Journal Title

      Physiol Rep

      Volume: 6(19) Issue: 19 Pages: e13884-e13884

    • DOI

      10.14814/phy2.13884

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure2018

    • Author(s)
      Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Sci Rep

      Volume: 8(1) Issue: 1 Pages: 12035-12035

    • DOI

      10.1038/s41598-018-30616-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid binding protein-4 and -5 knockout mice.2018

    • Author(s)
      Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Cardiovasc Res.

      Volume: - Issue: 8 Pages: 1132-1144

    • DOI

      10.1093/cvr/cvy063

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice.2017

    • Author(s)
      Umbarawan Y, Syamsunarno MR, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T
    • Journal Title

      Metabolism, clinical and experimental.

      Volume: - Pages: 47-57

    • DOI

      10.1016/j.metabol.2017.09.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association Between Circulating Ketone Bodies and Worse Outcomes in Hemodialysis Patients2017

    • Author(s)
      Obokata Masaru、Negishi Kazuaki、Sunaga Hiroaki、Ishida Hideki、Ito Kyoko、Ogawa Tetsuya、Iso Tatsuya、Ando Yoshitaka、Kurabayashi Masahiko
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 10

    • DOI

      10.1161/jaha.117.006885

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise2017

    • Author(s)
      Iso Tatsuya、Sunaga Hiroaki、Matsui Hiroki、Kasama Shu、Oshima Naomi、Haruyama Hikari、Furukawa Nozomi、Nakajima Kiyomi、Machida Tetsuo、Murakami Masami、Yokoyama Tomoyuki、Kurabayashi Masahiko
    • Journal Title

      Clinical Biochemistry

      Volume: 50 Issue: 16-17 Pages: 896-902

    • DOI

      10.1016/j.clinbiochem.2017.05.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 心臓の脂肪酸取り込み機構の全容とその障害が心機能に及ぼす影響2017

    • Author(s)
      磯 達也
    • Journal Title

      循環器内科

      Volume: 81 Pages: 476-482

    • NAID

      40021223513

    • Related Report
      2017 Research-status Report
  • [Presentation] Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy2019

    • Author(s)
      Kawakami R, Umbarawan Y, Iso T, Koitabashi N, Sunaga H, Matsui H, Kurabayashi M.
    • Organizer
      The 3rd JCS Council Forum on Basic Cardio Vascular Research
    • Related Report
      2019 Annual Research Report
  • [Presentation] Changes in fatty acid composition by Elovl6 ameliorates pressure overload-induced cardiac remodeling through maintenance of mitochondrial integrity in cardiac myocyte2019

    • Author(s)
      Tadaki S, Matsui H, Sunaga H, Umbarawan Y, Furukawa N, Iso T, Koitabashi N, Matsuzaka T, Simano H, Kurabayashi M, Yokoyama T.
    • Organizer
      The 92nd annual meeting of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced Fatty Acid Uptake Aggravates Cardiac Contractile Dysfunction in Streptozotocin-induced Diabetic Cardiomyopathy2019

    • Author(s)
      Kawakami R, Umbarawan Y, Iso T, Koitabashi N, Sunaga H, Matsui H, Kurabayashi M.
    • Organizer
      The 92nd annual meeting of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum free fatty acid composition as a critical regulator for cardiac fibroblast growth factor 21 production in patients with acute myocardial infarction2019

    • Author(s)
      Sunaga H, Koitabashi N, Matsui H, Iso T, Furukawa N, Kawakami R, Yokoyama T, Kurabayashi M.
    • Organizer
      The 92nd annual meeting of American Heart Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy2019

    • Author(s)
      Kawakami R, Umbarawan Y, Iso T, Koitabashi N, Sunaga H, Matsui H, Kurabayashi M.
    • Organizer
      第36回国際心臓研究学会日本部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] AMPK-KLF4 Signaling Activated by the Change of Intracellular FA Composition Regulates Mitochondrial Integrity2019

    • Author(s)
      今友里衣、松井弘樹、須永浩章、古川希、小板橋紀通、磯達也、横山知行、倉林正彦
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Therapeutic Vaccine against S100A9 Inhibits Thrombosis without Increasing the Risk of Bleeding2019

    • Author(s)
      中神啓徳、島村宗尚、河野友裕、磯達也、森下竜一
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Deranged Fatty Acid Composition by Elovl6 Regulates Cardiac Inflammation and Fibrosis after Pressure Overload in Mice2019

    • Author(s)
      Saitoh M, Matsui H, Sunaga H, Umbarawan Y, Furukawa N, Koitabashi N, Iso T, Yokoyama T, Kurabayashi M
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Serum Free Fatty Acid Composition as a Critical Regulator for Cardiac FGF21 Production in Patients with Acute Myocardial Infarction2019

    • Author(s)
      須永浩章、小板橋紀通、松井弘樹、磯達也、船田竜一、笠間周、高間典明、長坂崇司、横山知行、倉林正彦
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Activation of Cardiac AMPK-FGF21 Pathway during Acute Myocardial Infarction2019

    • Author(s)
      Sunaga H, Koitabashi N, Matsui H, Iso T, Funada R, Kasama S, Takama N, Nagasaka T, Yokoyama T, Kurabayashi M
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Fatty Acids as Central Fuels for Overloaded Hearts: Estimation of Catabolism and Anabolism in vivo Pressure-overloaded Hearts2019

    • Author(s)
      磯 達也, Umbarawan Y, Syamsunarno MR, 須永浩章、松井弘樹、小板橋紀通、倉林正彦
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Circulating FABP4 is Eliminated by the Kidney via Glomerular Filtration followed by Megalin-mediated Reabsorption2019

    • Author(s)
      Iso T, Shrestha S, Sunaga H, Kurabayashi M
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Genetic Deletion of Fatty Acid Synthase in Vascular Smooth Muscle Cell Ameliorates Monocrotaline-induced PAH in Mice2019

    • Author(s)
      古川聡子、松井弘樹、須永浩章、古川希、小板橋紀通、磯達也、横山知行、倉林正彦
    • Organizer
      第83回 日本循環器学会、横浜(パシフィコ横浜)
    • Related Report
      2018 Research-status Report
  • [Presentation] Circulating FABP4 is Eliminated by the Kidney via Glomerular Filtration followed by Megalin-mediated Reabsorption2018

    • Author(s)
      Shrestha S, Iso T, Sunaga H, Kurabayashi M
    • Organizer
      CVMW2018心血管代謝週間、第35回国際心臓研究学会日本部会
    • Related Report
      2018 Research-status Report
  • [Presentation] FGF21は急性心筋梗塞における心筋代謝ストレスを示す新たなバイオマーカーである2018

    • Author(s)
      須永浩章、小板橋紀通、松井弘樹、磯達也、横山知行、村上正巳、倉林正彦
    • Organizer
      CVMW2018心血管代謝週間、第40回心筋生検研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Circulating FABP4 is removed by the Kidney via Glomerular Filtration and Megalin-mediated Reabsorption2018

    • Author(s)
      Iso T, Shrestha S, Sunaga H, Kurabayashi
    • Organizer
      The 2nd JCS Council Forum on Basic Cardio Vascular Research(奈良春日野国際フォーラム)
    • Related Report
      2018 Research-status Report
  • [Presentation] Elevation of Serum Fibroblast Growth Factor 21 in Patients With Acute Myocardial Infarction: A Potential Role of AMPK Activation Following Sympathetic Overdrive2018

    • Author(s)
      Sunaga H, Koitabashi N, Matsui H, Iso T, Yokoyama T, Kurabayashi M
    • Organizer
      The 91st annual meeting of American Heart Association, McCormick Place, Chicago, USA
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Suppression of cardiac catabolism with accumulation of energy substrates during LPS-induced cardiac dysfunction2018

    • Author(s)
      Tatsuya Iso, Yogi Umbarawan, Hiroaki Sunaga, Hiroki Matsui, Norimichi Koitabashi, Masahiko Kurabayashi.
    • Organizer
      The 1st JCS Council Forum on Basic Cardio Vascular Research
    • Related Report
      2017 Research-status Report
  • [Presentation] Vital role of glucose as biomass synthesis substrate in CD36 deficient heart under pressure overload2018

    • Author(s)
      Yogi Umbarawan, Tatsuya Iso, Mas Rizky Syamsunarno, Norimichi Koitabashi, Masahiko Kurabayashi.
    • Organizer
      The 1st JCS Council Forum on Basic Cardio Vascular Research
    • Related Report
      2017 Research-status Report
  • [Presentation] Circlating Ketone Body as a Novel biomarker for Worse Clinical Outcomes in Hemodialysis Patients2018

    • Author(s)
      Sunaga H, Obokata M, Negishi K, Ogawa T, Iso T, Koitabashi N, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Glucose is Preferably Utilized for Biomass Synthesis Rather than ATP Production in Pressure-overloaded CD36 Deficient Heart2018

    • Author(s)
      Umbarawan Y, Mas Rizky AA Syamsunarno, Koitabashi N, Kurabayashi M, Iso T
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Kidney is an Essential Organ for Clearance of Circulating FABP42018

    • Author(s)
      Iso T, Shrestha S, Sunaga H, Yogi Umbarawan, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Robust Activation of Malate-aspartate Shuttle Coupled with Accelerated Glycolysis is Nearly Suppressed by Lipopolysaccharide-induced Cardiac Dysfunction in FABP4/5 Knockout Mice2018

    • Author(s)
      Umbarawan Y, Mas Rizky AA Syamsunarno, Koitabashi N, Kurabayashi M, Iso T
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP4 and -5 Play a Crucial Role in Exercise Endurance during Prolonged Fasting in Mice2018

    • Author(s)
      Iso T, Haruyama H, Sunaga H, Umbarawan Y, Matsui H, Yokoyama T, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibition of Fatty Acid Synthase Suppresses Vascular Smooth Muscle Cell Proliferation and Neointimal Formation: Potential Therapeutic Target in Atherosclerosis2018

    • Author(s)
      Matsui H, Sunaga H, Iso T, Yokoyama T, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identificaion and Molecular Mechanisms of Fibroblast Growth Factor 21 as a Novel Biomarker for Metabolic Stress in Acute Myocardial Infarction2018

    • Author(s)
      Koitabashi N, Sunaga H, Matsui H, Iso T, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Elovl6-driven Fatty Acid Metabolism Regulates Hypertrophic Response in the Heart Subjected to Pressure Overload in Mice2018

    • Author(s)
      Sunaga H, Matsui H, Iso T, Koitabashi N, Shimano H, Yokoyama T, Kurabayashi M
    • Organizer
      第82回 日本循環器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Limited Utilization of Fatty Acid With a Marked Increase in Glucose Uptake Exacerbates Cardiac Dysfunction During Pressure Overload in CD36 Deficient Mice2017

    • Author(s)
      Umbarawan Y, Syamsunarno M, Koitabashi N, Kurabayashi M, Iso T.
    • Organizer
      The 90th annual meeting of American Heart Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Robust Suppression of Cardiac Energy Catabolism With Marked Accumulation of EneSubstrates During Lipopolysaccharide-Induced Cardiac Dysfunction in Mice2017

    • Author(s)
      Umbarawan Y, Syamsunarno M, Koitabashi N, Kurabayashi M, Iso T.
    • Organizer
      The 90th annual meeting of American Heart Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A robust increase in glucose uptake independently of insulin exacerbates rather than ameliorates cardiac dysfunction under septic condition2017

    • Author(s)
      Umbarawan Y, Syamsunarno M, Iso T, Koitabashi N, Kurabayashi M.
    • Organizer
      European Society of Cardiology Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脂肪酸合成酵素FASは血管平滑筋の増殖と新生内膜肥厚の形成に重要である2017

    • Author(s)
      松井弘樹、須永浩章、大島奈緒美、磯 達也、横山知行、倉林正彦.
    • Organizer
      第25回日本血管生物医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸伸長酵素Elovl6により調整される脂肪酸代謝は圧負荷誘導性の心肥大を制御する2017

    • Author(s)
      須永浩章、松井弘樹、磯 達也、小板橋紀通、松坂賢、島野仁、横山知行、倉林正彦
    • Organizer
      第21回日本心血管内分泌代謝学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Vital role of glucose as biomass synthesis substrate in CD36 deficient heart under pressure overload2017

    • Author(s)
      Yogi Umbarawan, Tatsuya Iso, Mas Rizky Syamsunarno, Norimichi Koitabashi, Masahiko Kurabayashi.
    • Organizer
      第34回国際心臓研究学会日本部会 (ISHR)
    • Related Report
      2017 Research-status Report
  • [Book] Handbook of Famine, Starvation, and Nutrient Deprivation2018

    • Author(s)
      Tatsuya Iso, Kurabayashi Masahiko, edited by Drs. Preedy and Patel
    • Total Pages
      20
    • Publisher
      Springer International Publishing
    • ISBN
      9783319553863
    • Related Report
      2017 Research-status Report
  • [Remarks] 群馬大学大学院医学系研究科内科学講座循環器内科学 HOME>基礎研究>磯グループ

    • URL

      https://gucvmed.med.gunma-u.ac.jp/?page_id=94

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://gunma-u-med2.jp/%E6%95%99%E5%AE%A4%E7%B4%B9%E4%BB%8B/%E5%9F%BA%E7%A4%8E%E7%A0%94%E7%A9%B6%E9%83%A8%E9%96%80/

    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://gunma-u-med2.jp/%E5%8C%BB%E5%B8%AB%E5%8B%9F%E9%9B%86-top/%E5%A4%A7%E5%AD%A6%E9%99%A2/

    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://gunma-u-med2.jp/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97/%E5%8C%BB%E7%99%82%E3%82%B0%E3%83%AB%E3%83%BC%E3%83%97-%E5%BE%AA%E7%92%B0%E5%99%A8%E5%86%85%E7%A7%91/

    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://gunma-u-med2.jp/%E3%82%B9%E3%82%BF%E3%83%83%E3%83%95%E7%B4%B9%E4%BB%8B/%E7%A3%AF%E9%81%94%E4%B9%9F/

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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