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Role of mitochondrial import machinery in cardiac remodeling and its application for treatment

Research Project

Project/Area Number 17K09581
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyushu University

Principal Investigator

Shouji Matsushima  九州大学, 大学病院, 助教 (80552869)

Co-Investigator(Kenkyū-buntansha) 筒井 裕之  九州大学, 医学研究院, 教授 (70264017)
井手 友美  九州大学, 医学研究院, 准教授 (90380625)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心不全 / ミトコンドリア / 蛋白取込 / 酸化ストレス / 心筋リモデリング / 循環器・高血圧
Outline of Final Research Achievements

In this study, we iaimded to eludicate the role of Tom/Tim complex in cardiac remodeling. In post-infarted hearts, Tim44 protein levels were decreased. Overexpression of Tim44 attenuated left ventricular dilatation and dysfunction, increaseed mitochondiral SOD, and decreased protein carbonylation. In contray, Tim44 knokout demonstrated the opposite effects. These data indictate that Tim44 play a protective role in cardiac remodeling by incraseding import of SOD into mitochondia.

Academic Significance and Societal Importance of the Research Achievements

本研究により心筋リモデリングの病態理解が進むのみならず、ミトコンドリア取り込み機能の役割が明らかになり、新たな心不全治療戦略に発展する可能性を有している。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2020 2019 2018 2017

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)?Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1?Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway2020

    • Author(s)
      Okabe Kosuke、Matsushima Shouji、Ikeda Soichiro、Ikeda Masataka、Ishikita Akihito、Tadokoro Tomonori、Enzan Nobuyuki、Yamamoto Taishi、Sada Masashi、Deguchi Hiroko、Shinohara Keisuke、Ide Tomomi、Tsutsui Hiroyuki
    • Journal Title

      Hypertension

      Volume: 75 Issue: 4 Pages: 991-1001

    • DOI

      10.1161/hypertensionaha.119.14400

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway.2019

    • Author(s)
      Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, Enzan N, Yamamoto T, Sada M, Deguchi H, Morimoto S, Ide T, Tsutsui H
    • Journal Title

      Scientific reports

      Volume: 9 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-019-46367-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simple Risk Score to Predict Survival in Acute Decompensated Heart Failure - A2B Score.2019

    • Author(s)
      Nakada Y, Kawakami R, Matsushima S, Ide T, Kanaoka K, Ueda T, Ishihara S, Nishida T, Onoue K, Soeda T, Okayama S, Watanabe M, Okura H, Tsuchihashi-Makaya M, Tsutsui H, Saito Y.
    • Journal Title

      Circ J

      Volume: 5 Pages: 1019-1024

    • NAID

      130007636973

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Lessons Learned From Heart Failure Registries in Japan.2019

    • Author(s)
      Tomomi Ide, Hidetaka Kaku, Shouji Matsushima, Hiroyuki Tsutsui
    • Journal Title

      Fukuoka Acta Med.

      Volume: 3 Pages: 45-56

    • NAID

      120006551565

    • Related Report
      2018 Research-status Report
  • [Journal Article] Regulates Mitochondrial Iron Homeostasis Interacting with Transferrin Receptor.2018

    • Author(s)
      Furihata T, Takada S, Maekawa S, Mizushima W, Watanabe M, Takahashi H, Fukushima A, Tsuda M, Matsumoto J, Kakutani N, Yokota T, Otsuka Y, Matsushima S, Matsumoto M, Nakayama K, Nio-Kobayashi J, Iwanaga T, Sabe H, Hatakeyama S, Tsutsui H, Kinugawa S
    • Journal Title

      bioRxiv

      Volume: 10

    • Related Report
      2018 Research-status Report
    • Open Access
  • [Journal Article] Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome2017

    • Author(s)
      Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Omokawa M, Kadoguchi T, Takahashi M, Fukushima A, Matsushima S, Yamato M, Okita K, Tsutsui H
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 4 Pages: 1-6

    • DOI

      10.1111/jdi.12606

    • NAID

      120006337767

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mitochondrial redox regulation in cardiac remodeling2018

    • Author(s)
      Matsushima S
    • Organizer
      The 35th Annual Meeting of the ISHR Japanese Section
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The role of hexosamine biosynthetic pathway and O’GlcNAcylation in cardiac hypertrophy2018

    • Author(s)
      Matsushima S, Ishikita Akihito, Tsutsui H
    • Organizer
      The 9th Asian Pacific Congress of Heart Failure
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Fyn Regulates Subcellular Redox Signaling in Cardiac Remodeling2018

    • Author(s)
      松島将士
    • Organizer
      第82回日本循環器学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] yrosine kinase FYN is a novel regulator of NADPH oxidase4 in cardiac remodeling2017

    • Author(s)
      松島将士
    • Organizer
      第21回日本心不全学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 心不全-最新の基礎・臨床研究の進歩-2018

    • Author(s)
      松島 将士
    • Total Pages
      500
    • Publisher
      日本臨床
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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