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PPARgamma nanomedicine that promotes cardiac healing after acute myocardial infarction

Research Project

Project/Area Number 17K09590
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyushu University

Principal Investigator

Matoba Tetsuya  九州大学, 大学病院, 講師 (20448426)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords心筋梗塞 / 炎症 / マクロファージ / ナノテクノロジー / 急性心筋梗塞 / 核受容体 / ドラッグデリバリーシステム / 組織修復 / 循環器内科学
Outline of Final Research Achievements

In a mouse model, myocardial ischemia-reperfusion causes sequential inflammation by M1 pro-inflammatory macrophages and M2 tissue healing macrophages. A nano-medicine containing PPAR gamma agonist pioglitazone, injected at repefusion, reduced infarct size by skewing macrophage polarity toward less-inflammatory, resulting in an inhibition of left ventricular remodeling and improvement of prognosis in the mouse model.

Academic Significance and Societal Importance of the Research Achievements

この研究により、急性心筋梗塞病態における急性炎症と組織修復の制御による新しい疾病治療コンセプトを示すとともに、ナノ医薬プラットフォームの有用性を示すことができた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia?reperfusion injury by inhibiting monocyte-mediated inflammation in mice2019

    • Author(s)
      Fujiwara Masaki、Matoba Tetsuya、Koga Jun-Ichiro、Okahara Arihide、Funamoto Daiki、Nakano Kaku、Tsutsui Hiroyuki、Egashira Kensuke
    • Journal Title

      Cardiovascular Research

      Volume: 115 Issue: 7 Pages: 1244-1255

    • DOI

      10.1093/cvr/cvz066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing monocyte/macrophage polarization in preclinical animal models2018

    • Author(s)
      Tokutome Masaki、Matoba Tetsuya、Nakano Yasuhiro、Okahara Arihide、Fujiwara Masaki、Koga Jun-Ichiro、Nakano Kaku、Tsutsui Hiroyuki、Egashira Kensuke
    • Journal Title

      Cardiovascular Research

      Volume: 115 Issue: 2 Pages: 419-431

    • DOI

      10.1093/cvr/cvy200

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-mediated drug delivery system for atherosclerotic cardiovascular disease2017

    • Author(s)
      Matoba Tetsuya、Koga Jun-ichiro、Nakano Kaku、Egashira Kensuke、Tsutsui Hiroyuki
    • Journal Title

      Journal of Cardiology

      Volume: 70 Issue: 3 Pages: 206-211

    • DOI

      10.1016/j.jjcc.2017.03.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory Nanomedicine for Cardiovascular Disease2017

    • Author(s)
      Katsuki Shunsuke、Matoba Tetsuya、Koga Jun-ichiro、Nakano Kaku、Egashira Kensuke
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 4 Pages: 1383-1395

    • DOI

      10.3389/fcvm.2017.00087

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Targeting Inflammation in Acute Myocardial Infarction.2019

    • Author(s)
      的場哲哉、古賀純一郎、江頭健輔
    • Organizer
      第51回日本動脈硬化学会総会・学術集会(2019年7月11-12日、京都)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 炎症をターゲットする新しい動脈硬化治療2019

    • Author(s)
      的場哲哉
    • Organizer
      第19回動脈硬化教育フォーラム教育講演(2019年2月3日、福岡)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Targeting Cyclophilin D and Inflammation with Nano-medicines in Myocardial Ischemia-Reperfusion Injury.2019

    • Author(s)
      Tetsuya Matoba
    • Organizer
      3rd Annual 2019 International Hawaii Cardiovascular Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 九州大学循環器内科・冠動脈疾患・動脈硬化研究グループ

    • URL

      https://www.cardiol.med.kyushu-u.ac.jp/research/ascvd/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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