Role of the clock gene Clif/Bmal2 in cardiovascular diseases

• Project/Area Number: 17K09592
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: MAEMURA Koji 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Co-Investigator(Kenkyū-buntansha): 池田 聡司 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159) ; 砂河 孝行 長崎大学, 医歯薬学総合研究科(医学系), 助教 (40418637)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 循環器疾患 / 時計遺伝子 / 概日時計 / 遺伝子改変マウス / 循環器・高血圧 / 遺伝子 / 発現制御 / 概日リズム

Outline of Final Research Achievements

The identification and characterization of mammalian clock genes revealed that the biological clock is composed of feedback loops of transcription factors. Recent studies showed that the circadian clock is closely related to the pathogenesis of metabolic, immunological, and cardiovascular diseases.
We previously identified a clock gene Clif/Bmal2 from vascular endothelial cells. To further investigate the function of Clif/Bmal2, we generated the Clif/Bmal2 knockout mice. The Knockout mice were born normally, showed no abnormalities in growth or behavioral circadian rhythms, nor abnormal blood glucose or lipid profiles. We generated a hypoxic pulmonary hypertension model, but no knockout effect was observed. So far, we cannot show the effect of Clif/Bmal2 knockout. It may be due to the compensation by Bmal1.

Academic Significance and Societal Importance of the Research Achievements

体内時計の分子機序が明らかになり、その構成因子である時計遺伝子を変異させた動物の解析により、代謝疾患、免疫疾患、循環器疾患などの発症、進展に体内時計の乱れが重要な働きを担っていることが明らかになっている。今回時計遺伝子の１つであるClif/Bmal2のノックアウトマウスを作製しその解析を行った。今までのところノックアウトによる影響は明らかでないが、さらに様々な病態モデルで検討し、その機能を明らかにすることにより、体内時計への介入による治療である時間治療を代謝疾患や循環器疾患に応用できると考えられる。

Research Products

• [Journal Article] Establishment of Novel High-Standard Chemiluminescent Assay for NTPase in Two Protozoans and Its High-Throughput Screening (2020)
  • Author(s): Masamitsu Harada, Jun Nagai, Riho Kurata, Kenji Shimizu, Xiaofeng Cui, Takayuki Isagawa, Hiroaki Semba, Jun Ishihara, Yasuhiro Yoshida, Norihiko Takeda, Koji Maemura, Tomo Yonezawa
  • Journal Title: Marine Drugs Volume: 18 Issue: 3 Pages: 161-161
  • DOI: 10.3390/md18030161
  • NAID: 120006988256
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening (2020)
  • Author(s): Kurata R, Shimizu K, Cui X, Harada M, Isagawa T, Semba H, Ishihara J, Yamada K, Nagai J, Yoshida Y, Takeda N, Maemura K, Yonezawa T.
  • Journal Title: Marine Drugs Volume: 18 Issue: 1 Pages: 60-60
  • DOI: 10.3390/md18010060
  • NAID: 120006988310
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diagnostic Criteria of Flow‐Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin‐Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery (2020)
  • Author(s): Maruhashi Tatsuya、Tomiyama Hirofumi、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Journal of the American Heart Association Volume: 9 Issue: 2
  • DOI: 10.1161/jaha.119.013915
  • NAID: 120006941134
  • Peer Reviewed / Open Access
• [Journal Article] The Relationship between Circulating Polyunsaturated Fatty Acid Levels and Exercise Responses of Patients with Non-ischemic Heart Failure (2019)
  • Author(s): Izumida Seiya、Kawano Hiroaki、Muroya Takahiro、Motokawa Tetsufumi、Akashi Ryohei、Yonekura Tsuyoshi、Morimoto Yosuke、Yano Yudai、Ikeda Satoshi、Maemura Koji
  • Journal Title: Internal Medicine Volume: 58 Issue: 22 Pages: 3219-3225
  • DOI: 10.2169/internalmedicine.2849-19
  • NAID: 130007746025
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-11-15
  • Peer Reviewed / Open Access
• [Journal Article] Cell Cycle Perturbation Induces Collagen Production in Fibroblasts (2019)
  • Author(s): Wake M, Takeda N, Isagawa T, Sato T, Nakagama Y, Morioka MS, Hirota Y, Asagiri M, Maemura K, Manabe I, Tanabe K, Komuro I.
  • Journal Title: International Heart Journal Volume: 60 Issue: 4 Pages: 958-963
  • DOI: 10.1536/ihj.18-710
  • NAID: 130007684138
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-07-30
  • Peer Reviewed / Open Access
• [Journal Article] Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ― (2019)
  • Author(s): Kajikawa Masato、Noma Kensuke、Nakashima Ayumu、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Circulation Journal Volume: 83 Issue: 5 Pages: 1064-1071
  • DOI: 10.1253/circj.CJ-18-1082
  • NAID: 130007636980
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-04-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interaction Between the Gut-Kidney-Cardiovascular Systems Is Key in Predicting the Prognosis of Patients with Cardiovascular Disease (2019)
  • Author(s): Ikeda Satoshi、Maemura Koji
  • Journal Title: International Heart Journal Volume: 60 Issue: 1 Pages: 7-9
  • DOI: 10.1536/ihj.18-672
  • NAID: 130007557121
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-01-31
  • Peer Reviewed / Open Access
• [Journal Article] Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease (2019)
  • Author(s): Tomiyama Hirofumi、Maruhashi Tatsuya、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 24
  • DOI: 10.1161/jaha.119.013004
  • NAID: 120006786177
  • Peer Reviewed / Open Access
• [Journal Article] Biomarkers of Cardiac Dysfunction as Risk Factors in Cryptogenic Stroke (2019)
  • Author(s): Tateishi Yohei、Kanamoto Tadashi、Yamashita Kairi、Hirayama Takuro、Yoshimura Shunsuke、Miyazaki Teiichiro、Tsuneto Akira、Maemura Koji、Morofuji Yoichi、Horie Nobutaka、Izumo Tsuyoshi、Shiraishi Hirokazu、Tsujino Akira
  • Journal Title: Cerebrovascular Diseases Volume: 48 Issue: 3-6 Pages: 132-139
  • DOI: 10.1159/000504014
  • Peer Reviewed
• [Journal Article] Differential predictive factors for cardiovascular events in patients with or without cancer history. (2019)
  • Author(s): Sueta D, Tabata N, Ikeda S, Saito Y, Ozaki K, Sakata K, Matsumura T, Yamamoto-Ibusuki M, Murakami Y, Jodai T, Fukushima S, Yoshida N, Kamba T, Araki E, Iwase H, Fujii K, Ihn H, Kobayashi Y, Minamino T, Yamagishi M, Maemura K, Baba H, Matsui K, Tsujita K.
  • Journal Title: Medicine (Baltimore). Volume: 98 Issue: 44 Pages: e17602-e17602
  • DOI: 10.1097/md.0000000000017602
  • Peer Reviewed / Open Access
• [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M. (2019)
  • Author(s): Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 2824-2833
  • DOI: 10.1038/s41467-019-10859-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of blood pressure lowering in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis (2019)
  • Author(s): Kawano H、Fujiwara A、Kai H、Kumagai E、Okamoto R、Shibata R、Ohtsubo T、Tamura K、Maemura K、Hisatomi A
  • Journal Title: Hypertension Research Volume: 42 Issue: 4 Pages: 504-513
  • DOI: 10.1038/s41440-019-0216-8
  • Peer Reviewed
• [Journal Article] Effectiveness and safety of oral direct factor Xa inhibitors for the treatment of venous thromboembolism in patients with cancer and/or older age (2019)
  • Author(s): Sato D, Ikeda S, Koga S, Yamagata Y, Eguchi M, Yonekura T, Tsuneto A, Yoshimuta T, Koide Y, Kawano H, Maemura K
  • Journal Title: Heart Vessels Volume: 34 Issue: 4 Pages: 678-687
  • DOI: 10.1007/s00380-018-1283-5
  • Peer Reviewed
• [Journal Article] 睡眠・サーカディアンリズムと心不全 (2019)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 77 Pages: 579-586
• [Journal Article] A score using left ventricular diastolic dysfunction to predict 90-day mortality in acute ischemic stroke: The DONE score (2019)
  • Author(s): Tateishi Yohei、Kanamoto Tadashi、Nakaoka Kenjiro、Yoshimura Shunsuke、Miyazaki Teiichiro、Shiraishi Hirokazu、Morimoto Shimpei、Tsuneto Akira、Maemura Koji、Morofuji Yoichi、Horie Nobutaka、Izumo Tsuyoshi、Tsujino Akira
  • Journal Title: Journal of the Neurological Sciences Volume: 398 Pages: 157-162
  • DOI: 10.1016/j.jns.2019.01.021
  • NAID: 120006987785
  • Peer Reviewed
• [Journal Article] Lower Circulating Omega-3 Polyunsaturated Fatty Acids Are Associated with Coronary Microvascular Dysfunction Evaluated by Hyperemic Microvascular Resistance in Patients with Stable Coronary Artery Disease (2018)
  • Author(s): Muroya Takahiro、Kawano Hiroaki、Koga Seiji、Ikeda Satoshi、Yamamoto Fumi、Miwa Takashi、Kohno Yusuke、Maemura Koji
  • Journal Title: International Heart Journal Volume: 59 Issue: 6 Pages: 1194-1201
  • DOI: 10.1536/ihj.17-459
  • NAID: 130007521712
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-11-30
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the Brachial-ankle Pulse Wave Velocity between Patients with Acute Coronary Syndrome and Effort Angina Pectoris (2018)
  • Author(s): Yamasa Toshihiko、Ikeda Satoshi、Koga Seiji、Kawano Hiroaki、Kaibara Shuuhei、Maemura Koji
  • Journal Title: Internal Medicine Volume: 57 Issue: 10 Pages: 1371-1374
  • DOI: 10.2169/internalmedicine.9367-17
  • NAID: 130006734419
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-05-15
  • Peer Reviewed
• [Journal Article] Comparison of the effects of edoxaban, an oral direct factor Xa inhibitor, on venous thromboembolism between patients with and without cancer. (2018)
  • Author(s): Ikeda S, Koga S, Yamagata Y, Eguchi M, Sato D, Muroya T, Yonekura T, Tsuneto A, Yoshimuta T, Koide Y, Kawano H, Maemura K.
  • Journal Title: J Cardiol Volume: 印刷中 Issue: 2 Pages: 120-127
  • DOI: 10.1016/j.jjcc.2018.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of organ involvement in systemic sclerosis by serum biomarkers and peripheral endothelial function (2018)
  • Author(s): Kawashiri SY, Nishino A, Igawa T, Takatani A, Shimizu T, Umeda M, Fukui S, Okada A, Suzuki T, Koga T, Iwamoto N, Ichinose K, Tamai M, Nakashima M, Mizokami A, Matsuoka N, Migita K, Ogawa F, Ikeda S, Maemura K, Nakamura H, Origuchi T, Maeda T, Kawakami A.
  • Journal Title: Clin Exp Rheumatol. Volume: 113 Pages: 102-108
  • Peer Reviewed / Open Access
• [Journal Article] Balloon pulmonary angioplasty is effective for treating peripheral-type chronic thromboembolic pulmonary hypertension in elderly patients. (2018)
  • Author(s): Yamagata Y, Ikeda S, Nakata T, Yonekura T, Koga S, Muroya T, Koide Y, Kawano H, Maemura K.
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 5 Pages: 678-684
  • DOI: 10.1111/ggi.13224
  • Peer Reviewed / Open Access
• [Journal Article] 『時間』を軸に考えた糖尿病治療の新展開】循環器疾患・糖尿病の時間治療 (2018)
  • Author(s): 前村浩二
  • Journal Title: 月刊 糖尿病 DIABETES Volume: 10 Pages: 83-92
• [Journal Article] Deeper S Wave in Lead V5 and Broader Extent of T Wave Inversions in the Precordial Leads are Clinically Useful Electrocardiographic Parameters for Predicting Pulmonary Hypertension (2018)
  • Author(s): Miura M, Ikeda S, Yoshida T, Yamagata Y, Nakata T, Koga S, Koide Y, Kawano H, Maemura K.
  • Journal Title: International Heart Journal Volume: 59 Issue: 1 Pages: 136-142
  • DOI: 10.1536/ihj.16-647
  • NAID: 130006321377
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study. (2018)
  • Author(s): Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Iwamoto A, Kajikawa M, Matsumoto T, Oda N, Kishimoto S, Matsui S, Hashimoto H, Aibara Y, Yusoff FM, Hidaka T, Kihara Y, Chayama K, Noma K, Maemura K,et al.
  • Journal Title: Atherosclerosis Volume: 268 Pages: 92-98
  • DOI: 10.1016/j.atherosclerosis.2017.11.022
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal association among endothelial function, arterial stiffness and subclinical organ damage in hypertension (2018)
  • Author(s): Tomiyama Hirofumi、Ishizu Tomoko、Higashi Yukihito、Ueda Shinichiro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Node Koichi
  • Journal Title: International Journal of Cardiology Volume: 253 Pages: 161-166
  • DOI: 10.1016/j.ijcard.2017.11.022
  • NAID: 120006956866
  • Peer Reviewed / Open Access
• [Journal Article] 循環器疾患の時間治療 (2018)
  • Author(s): 前村浩二
  • Journal Title: 循環器専門 Volume: 26 Pages: 11-18
  • NAID: 130007681609
• [Journal Article] Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. (2017)
  • Author(s): Oishi Y, Hayashi S, Isagawa T, Oshima M, Iwama A, Shimba S, Okamura H and Manabe I.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 7086-7086
  • DOI: 10.1038/s41598-017-07100-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] EVI1 modulates oncogenic role of GPC1 in pancreatic carcinogenesis (2017)
  • Author(s): Tanaka Mariko、Ishikawa Shumpei、Ushiku Tetsuo、Morikawa Teppei、Isagawa Takayuki、Yamagishi Makoto、Yamamoto Hiroyuki、Katoh Hiroto、Takeshita Kimiko、Arita Junichi、Sakamoto Yoshihiro、Hasegawa Kiyoshi、Kokudo Norihiro、Fukayama Masashi
  • Journal Title: Oncotarget Volume: 8 Issue: 59 Pages: 99552-99566
  • DOI: 10.18632/oncotarget.20601
  • Peer Reviewed / Open Access
• [Journal Article] Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. (2017)
  • Author(s): Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V, Stockmann C.
  • Journal Title: Nat Commun Volume: 8 Issue: 1 Pages: 1597-1597
  • DOI: 10.1038/s41467-017-01599-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endothelial Function Is Impaired in Patients Receiving Antihypertensive Drug Treatment Regardless of Blood Pressure Level (2017)
  • Author(s): Maruhashi Tatsuya、Soga Junko、Fujimura Noritaka、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Hypertension Volume: 70 Issue: 4 Pages: 790-797
  • DOI: 10.1161/hypertensionaha.117.09612
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of clinical symptoms and ABCC6 mutations in 76 Japanese patients with pseudoxanthoma elasticum. (2017)
  • Author(s): Iwanaga A, Okubo Y, Yozaki M, Koike Y, Kuwatsuka Y, Tomimura S, Yamamoto Y, Tamura H, Ikeda S, Maemura K, Tsuiki E, Kitaoka T, Endo Y, Mishima H, Yoshiura KI, Ogi T, Tanizaki H, Wataya-Kaneda M, Hattori T, Utani A.
  • Journal Title: Journal of Dermatology Volume: 印刷中 Issue: 6 Pages: 644-650
  • DOI: 10.1111/1346-8138.13727
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Morning Onset on the Incidence of Recurrent Acute Coronary Syndrome and Progression of Coronary Atherosclerosis in Acute Myocardial Infarction (2017)
  • Author(s): Nakashima H, Mashimo Y, Kurobe M, Muto S, Furudono S, Maemura K.
  • Journal Title: Circulation Journal Volume: 81 Issue: 3 Pages: 361-367
  • DOI: 10.1253/circj.CJ-16-0817
  • NAID: 130005242974
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Waist-to-Height Ratio and Endothelial Dysfunction in Patients With Morbidity ― A Report From the FMD-J Study ― (2017)
  • Author(s): Tokushige Akihiro、Ueda Shinichiro、Tomiyama Hirofumi、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka、Ishibashi Yutaka、Node Koichi、Ito Hiroshi、Yamashina Akira
  • Journal Title: Circulation Journal Volume: 81 Issue: 12 Pages: 1911-1918
  • DOI: 10.1253/circj.CJ-17-0211
  • NAID: 130006219151
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] 時計遺伝子と血管病 (2017)
  • Author(s): 前村浩二
  • Journal Title: 日本臨牀 Volume: 75 Pages: 1148-1153
• [Journal Article] 時間生物学視点の臨床応用への期待をこめて (2017)
  • Author(s): 前村浩二
  • Journal Title: 時間生物学 Volume: 23 Pages: 1-1
• [Presentation] 日本循環器学会の循環器病克服に対する取り組み (2019)
  • Author(s): 前村浩二
  • Organizer: 日本脳神経外科学会第78回学術総会
• [Presentation] Serum soluble Klotho is associated with extent of coronary artery calcification in patients with stable angina pectoris undergoing percutaneous coronary intervention (2019)
  • Author(s): S. Koga, S. Ikeda, R. Akashi, Y. Yamagata, T. Yonekura, H. Kawano, K. Maemura
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Potential for drug-drug interaction between vonoprazan and prasugrel on antiplatelet effect assessed by VerifyNow P2Y12 assay in patients with coronary artery disease (2019)
  • Author(s): S. Koga, S. Ikeda, R. Akashi, Y. Yamagata, T. Yonekura, H. Kawano, K. Maemura
  • Organizer: ESC Congress 2019
  • Int'l Joint Research
• [Presentation] Serum soluble Klotho is associated with extent of coronary artery calcification in patients with stable angina pectoris undergoing percutaneous coronary intervention (2019)
  • Author(s): Seiji Koga, Satoshi Ikeda, Ryohei Akashi, Yuki Yamagata, Tsuyoshi Yonekura, Hiroaki Kawano, Koji Maemura
  • Organizer: AHA 2019
  • Int'l Joint Research
• [Presentation] Direct Comparison of Resting Full-cycle Ratio with Fractional Flow Reserve in Physiological Assessment of Intermediate Coronary Artery Stenosis (2019)
  • Author(s): Tomohiro Honda, Seiji Koga, Ryohei Akashi, Yuki Yamagata, Tsuyoshi Yonekura, Satoshi Ikeda, Hiroaki Kawano, Koji Maemura
  • Organizer: AHA 2019
  • Int'l Joint Research
• [Presentation] Circulating soluble a-Klotho is inversely associated with coronary artery calcification evaluated by three-dimensional intravascular ultrasound (2018)
  • Author(s): Seiji Koga, Satoshi Ikeda, Ryohei Akashi, Yuki Yamagata, Tsuyoshi Yonekura, Takahiro Muroya, Yuji Koide, Hiroaki Kawano, Koji Maemura
  • Organizer: ESC congress 2018
  • Int'l Joint Research
• [Presentation] Oxidative stress-responsive apoptosis inducing protein (ORAIP), a new oxidative stress marker, is associated with pulmonary hemodynamics in chronic thromboembolic pulmonary hypertension (2018)
  • Author(s): Yuki Yamagata, Satoshi Ikeda, Tomoo Nakata, Tsuyoshi Yonekura, Masamichi Eguchi, Seiji Koga, Takahiro Muroya, Yuji Koide, Hiroaki Kawano, Takako Yao, Yoshinori Seko, Koji Maemura
  • Organizer: ESC congress 2018
  • Int'l Joint Research
• [Presentation] Cardio-ankle vascular index can predict coronary plaque characteristics assessed by iMap-intravascular ultrasound (2018)
  • Author(s): Ryohei Akashi, Seiji Koga, Tsuyoshi Yonekura, Takahiro Muroya, Yuji Koide, Satoshi Ikeda, Hiroaki Kawano, Koji Maemura
  • Organizer: ESC congress 2018
  • Int'l Joint Research
• [Presentation] Impact of obstructive sleep apnea on circadian variation of infarct size in patients with acute myocardial infarction (2018)
  • Author(s): Nakashima H, Fukushima T, Muto S, Furudono S, Nunohiro T, Maemura K
  • Organizer: ESC congress 2018
  • Int'l Joint Research
• [Presentation] Comprehensive searching for circulating microRNAs as a novel biomarker for pulmonary arterial hypertension (2018)
  • Author(s): Eguchi M, Ikeda S, Isagawa T, Kawano H, Maemura K
  • Organizer: American Heart Association 2019 Scientific Sessions
  • Int'l Joint Research
• [Presentation] Big Date in Japan:Challenges and Values (2017)
  • Author(s): Koji Maemura
  • Organizer: Asian Pacific Society of Cardiology2017
  • Int'l Joint Research / Invited
• [Presentation] シンポジウム「睡眠とアンチエイジング」 (2017)
  • Author(s): 前村浩二
  • Organizer: 脳心血管抗加齢研究会2017
• [Patent(Industrial Property Rights)] 肺高血圧症の予防または治療薬 (2020)
  • Inventor(s): 世古義規、村山季美枝、藤村努、前村浩二、江口正倫、森貴子
  • Industrial Property Rights Holder: 世古義規、村山季美枝、藤村努、前村浩二、江口正倫、森貴子
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020