| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages and plays significant roles in the development of insulin resistance and atherosclerosis. The present study demonstrated that FABP4 was ectopically induced in endothelial cells by cellular senescence and vascular injury. Furthermore, secreted FABP4 from injured vascular endothelial cells promoted inflammatory response in several cells, proliferation and migration in vascular smooth muscle cells, and endothelial dysfunction in vascular endothelial cells, leading to the development of neointima formation after vascular injury.
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