| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In order to clarify the physiological and pathological roles of the protein whose function is not known in cardiovascular morphogenesis and pathological conditions, we investigated one of the mechano-sensitive ion transporters with a high possibility of its interaction. We found a method to activate the mechano-sensitive ion transporter and identified inhibitors. In addition, an inhibitory antibody was produced and the epitope was identified. To elucidate the role of ion transporters in endothelial differentiation, we examined the effect of the inhibitory antibodies on endothelial mesenchymal transition. The inhibitory antibody treatment suppressed the metastasis of lung cancer induced by intravenously injecting highly metastatic myeloma cells to mice and the cardiac fibrosis in cardiomyopathic animal models. These experiments revealed that this ion transporter plays an important role in endothelial differentiation.
|
