Potential biological mechanisms with regard to the association betwen asthma and obesity

• Project/Area Number: 17K09599
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Satoshi Konno 北海道大学, 医学研究院, 教授 (20399835)
• Co-Investigator(Kenkyū-buntansha): 渡部 拓 北海道大学, 医学研究院, 助教 (90399949)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 気管支喘息 / 肥満 / メカニズム

Outline of Final Research Achievements

We demonstrated that abdominal visceral fat adiposity assessed by CT was significantly associated with asthma symptoms, both in males and females.The objective measurement of fat distribution did not recognize the sex difference of this phenotype. Regardless of sex, abdominal visceral fat was associated with reduced asthma quality of life independent of other obesity indices, and this association, at least partially, could be explained by the impact of abdominal visceral fat on reduced FEV1 % predicted and higher risk for GERD and depression.

Academic Significance and Societal Importance of the Research Achievements

吸入ステロイドの普及により気管支喘息のコントロールは良好となったが、罹患患者の増加及び、高用量の吸入ステロイドや経口ステロイドの使用下でもそのコ ントロールが不良である、いわゆる「難治性喘息」の存在は、現在の喘息診療の最重要課題である。気管支喘息の発症、難治化において、肥満は最も注目されて いる因子の一つである。
本研究により、肥満が喘息病態に与える影響を、ヒト検体、動物モデル、細胞培養を用い、その分子生物学的機序の一部が明らかとなった。今後、肥満喘息の治療戦略を構築する上での、貴重な基礎データになったと考えられる。

Research Products

• [Journal Article] Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms. (2019)
  • Author(s): Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
  • Journal Title: The Journal of Allergy and Clinical Immunology: In Practice. Volume: 7 Issue: 4 Pages: 1222-1229
  • DOI: 10.1016/j.jaip.2018.11.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of abdominal visceral adiposity on adult asthma symptoms (2019)
  • Author(s): Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
  • Journal Title: J Allergt Clin Immunol Pract Volume: 7 Pages: 1222-1229
  • Peer Reviewed
• [Journal Article] Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects (2018)
  • Author(s): Kimura H, Konno S, et al.
  • Journal Title: Allergology International Volume: 67 Issue: 3 Pages: 357-363
  • DOI: 10.1016/j.alit.2017.11.006
  • NAID: 130007420861
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Presentation] Differential impact of obesity indices on systemic and sputum inflammatory biomarkers (2019)
  • Author(s): Goudarzi H, Konno S, et al.
  • Organizer: European Respiratory Society Annual Congress
  • Int'l Joint Research
• [Presentation] Combined use of Th2 markers for identification of future exacerbation in severe asthma: an analysis from the Hokkaido Severe Asthma Cohort Study (2019)
  • Author(s): Kimura H, Konno S, et al.
  • Organizer: American Thoracic Society Annual Congress
  • Int'l Joint Research
• [Presentation] Impact of abdominal visceral adiposity on adult asthma symptoms (2019)
  • Author(s): Goudarzi H, Konno S, Kimura H, Makita H, Matsumoto M, Takei N, Kimura H, Shimizu K, Suzuki M, Ito YM, Nishimura M
  • Organizer: Eur Respiratory Scociety National Congress
  • Int'l Joint Research
• [Presentation] Three year follow-up on exacerbation rate in severe asthmatic subjects (2017)
  • Author(s): Kimura H, Konno S, et al.
  • Organizer: Am Thorac Soc International Meeting Washington DC, USA
  • Int'l Joint Research
• [Presentation] 重症喘息患者における3年間の増悪頻度及びその予測因子の検討 (2017)
  • Author(s): 木村孔一, 今野 哲ら
  • Organizer: 日本アレルギー学会学術大会 東京