Multicenter study for peripheral blood telomere length in patients with idiopathic pulmonary fibrosis
| Project/Area Number |
17K09612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Handa Tomohiro 京都大学, 医学研究科, 特定准教授 (10432395)
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| Co-Investigator(Kenkyū-buntansha) |
松田 文彦 京都大学, 医学研究科, 教授 (50212220)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 特発性肺線維症 / 遺伝子変異 / テロメア / ゲノム / 老化 / 遺伝子 / 内科 |
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| Outline of Final Research Achievements |
Peripheral blood telomere length was serially measured in 77 patients with idiopathic pulmonary fibrosis (IPF). In patients who were treated with anti-fibrotic drugs (treatment group), the telomere length tended to increase over time as compared with the non-treatnebt group (rate of change from baseline: treatment group 1.026 +/- 0.037 vs non-treatment group 1.016 +/- 0.032). A negative correlation was observed between changes of telomere length and those of peripheral blood MCP-1 after 12 months from baseline(r = -0.359, P <0.05). The result suggested that the peripheral blood telomere length may be extended by the administration of antifibrotic drugs in IPF, but the mechanism remains unclear. The telomre length will be measured until 24 months from baseline, and we are planning to evaluate telomerase activity in peripheral blood of IPF patients.
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| Academic Significance and Societal Importance of the Research Achievements |
特発性肺線維症は原因不明の肺疾患で、数年の間に呼吸不全が進行する難病である。近年抗線維化薬と称される薬剤がその進行を緩やかにする事が確認されて使用されているが、その有効性に関する詳しいメカニズムは明らかとなっていない。本研究では細胞寿命を規定する染色体のテロメア長に注目し、抗線維化薬との関連について研究を行った。特発性肺線維症では抗線維化薬の投与によって血液のテロメア長が伸長する傾向が確認され、それを介在する蛋白質を確認した。今後特発性肺線維症の新規治療戦略の発展に寄与すると考えられる。
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Report
(4 results)
Research Products
(18 results)
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[Presentation] Clinical and pathological features of idiopathic and secondary pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.2019
Author(s)
Ikegami N, Nakajima N, Tanizawa K, Yoshizawa A, Handa T, Chen-Yoshikawa T, Kubo T, Osumi A, Yamada Y, Hamaji M, Nakajima D, Yutaka Y, Tanaka S, Watanabe K, Nakatsuka Y, Murase Y, Nakanishi T, Niwamoto T, Chen K, Date H, Hirai T.
Organizer
European Respiratory Society Annual Congress
Related Report
Int'l Joint Research
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[Presentation] The predictive risk factors for lung cancer in patients with idiopathic pulmonary fibrosis.2018
Author(s)
Kohei Ikezoe, Tomohiro Handa, Kiminobu Tanizawa, Akihiko Sokai, Yoshinari Nakatsuka, Yuko Murase, Takeshi Kubo, Akihiko Yoshizawa, Sonoko Nagai, Kazuo Chin, Toyohiro Hirai
Organizer
114th American Thoracic Society International Conference
Related Report
Int'l Joint Research
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[Presentation] 血清matrix metalloproteinases-7の経時的変化は、特発性肺線維症の独立した予後因子である2018
Author(s)
村瀬裕子, 祖開曉彦, 半田知宏, 谷澤公伸, 宇野賀津子, 池添浩平, 中塚賀也, 徳田深作, 金谷久美子, 久保武, 小賀徹, 長井苑子, 陳和夫, 三嶋理晃, 平井豊博
Organizer
第58回日本呼吸器学会学術講演会
Related Report
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[Presentation] 肺移植を行った慢性過敏性肺炎に関する検討2018
Author(s)
池上直弥, 半田知宏, 陳豊史, 谷澤公伸, 吉澤明彦, 久保武, 渡辺創, 池添浩平, 中塚賀也, 村瀬裕子, 中西智子, 庭本崇史, 中島直樹, 伊達洋至, 陳和夫, 平井豊博
Organizer
第38回日本サルコイドーシス/肉芽腫性疾患学会総会
Related Report
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