Regulation of lung fibrosis targeting NETs
Project/Area Number |
17K09618
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Nagasaki University |
Principal Investigator |
SAKAMOTO Noriho 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30448493)
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Co-Investigator(Kenkyū-buntansha) |
迎 寛 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80253821)
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Project Period (FY) |
2017-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | NETs / pulmonary fibrosis / デフェンシン / 特発性肺線維症 / 間質性肺炎 / ヒストン / cell free DNA / 皮膚筋炎 / 関節リウマチ / 臨床 / 内科 / 肺線維症 |
Outline of Final Research Achievements |
NETs in patients with idiopathic pulmonary fibrosis were detected to elucidate the role of NETs in pulmonary fibrosis, and the association with their clinical characteristics was analyzed. The histone increased in the plasma, and cell free DNA and histone were both significantly higher in bronchoalveolar lavage fluid. There was a significant positive correlation between cell free DNA, histone and the ratio of neutrophils in bronchoalveolar lavage fluid. These results suggest that NETs may be useful as a biomarker for neutrophilic inflammation of idiopathic pulmonary fibrosis.
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Academic Significance and Societal Importance of the Research Achievements |
原因不明で予後不良な疾患である特発性肺線維症に対しては、その治療開発に加え有用なバイオマーカーの発見も期待されている。本研究では、好中球由来の物質であるNETsに着目し検討を行った。結果、肺局所から得られた気管支肺胞洗浄液中のNETsは、肺の好中球性炎症のバイオマーカーとなりうることが示唆された。肺局所の好中球が特発性肺線維症の病態促進に働く可能性も示されており、特発性肺線維症の病態解明、バイオマーカーとしての可能性、治療薬開発に繋がる基礎研究と考えられる。
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] Prediction of Anti-Cancer Drug-Induced Pneumonia in Lung Cancer Patients: Novel High-Resolution Computed Tomography Fibrosis Scoring.2020
Author(s)
Hiroshi Gyotoku, Hiroyuki Yamaguchi, Hiroshi Ishimoto, Shuntaro Sato, Hirokazu Taniguchi, Hiroaki Senju, Tomoyuki Kakugawa, Katsumi Nakatomi, Noriho Sakamoto, Minoru Fukuda, Yasushi Obase, Hiroshi Soda, Kazuto Ashizawa, Hiroshi Mukae
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Journal Title
J Clin Med
Volume: 9(4)
Issue: 4
Pages: 1045-1045
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer2020
Author(s)
Takuto Miyamura, Noriho Sakamoto, Kaori Ishida, Tomoyuki Kakugawa, Hirokazu Taniguchi , Yoshiko Akiyama, Daisuke Okuno, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Takeshi Nagayasu, Hiroshi Mukae
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Journal Title
Respiratory Research
Volume: 21(1)
Issue: 1
Pages: 234-234
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Small molecule inhibitor of HSP47 prevents pro-fibrotic mechanisms of fibroblasts in vitro.2020
Author(s)
Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Sakiko Moriyama, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Yoshimasa Tanaka, Hiroshi Mukae
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Journal Title
Biochem Biophys Res Commun
Volume: 530(3)
Issue: 3
Pages: 561-565
DOI
Related Report
Peer Reviewed
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[Journal Article] The acoustic characteristics of fine crackles predict honeycombing on high-resolution computed tomography2019
Author(s)
Fukumitsu T, Obase Y, Ishimatsu Y, Nakashima S, Ishimoto H, Sakamoto N, Nishitsuji K, Shiwa S, Sakai T, Miyahara S, Ashizawa K, Mukae H, Kozu R
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Journal Title
BMC Pulm Med
Volume: 19
Issue: 1
Pages: 153-153
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lymphocytic focus score is positively related to airway and interstitial lung diseases in primary Sjogren's syndrome2018
Author(s)
Kakugawa T, Sakamoto N, Ishimoto H, Shimizu T, Nakamura H, Nawata A, Ito C, Sato S, Hanaka T, Oda K, Kido T, Miyamura T, Nakashima S, Aoki T, Nakamichi S, Obase Y, Saito K, Yatera K, Ishimatsu Y, Nakayama T, Korogi Y, Kawakami A, Tanaka Y, Mukae H.
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Journal Title
Respiratory Medicine
Volume: 137
Pages: 95-102
DOI
Related Report
Peer Reviewed
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[Journal Article] The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis2017
Author(s)
Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, Kushima H, Ishii H, Akasaka K, Ono J, Kamei A, Azuma Y, Matsumoto H, Yamaguchi Y, Aihara M, Johkoh T, Kawaguchi A, Ichiki M, Sagara H, Kadota JI, Hanaoka M, Hayashi SI, Kohno S, Hoshino T, Izuhara K
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Journal Title
PloS one
Volume: 12
Issue: 3
Pages: e0174547-e0174547
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Immune Complexome Analysis Detects Apolipoprotein E as a Disease-Specific Immune Complex Antigen in Bronchoalveolar Fluids from Patients with Summer-Type Hypersensitivity Pneumonitis2020
Author(s)
Y. Ishimatsu, A. Hara, N. Aibara, K. Ohyama, Y. Akiyama, D. Okuno, T. Miyamura, T. Kido, H. Ishimoto, N. Sakamoto, H. Mukae
Organizer
ATS 2020-American Thoracic Society International Conference. Virtual
Related Report
Int'l Joint Research
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[Presentation] The Utility Of Combinate Detection Of Igh And Tcr Gene Rearrangement, And Malt1 Gene Translocation In Balf For The Diagnosis Of Pulmonary Lymphoma2020
Author(s)
T. Kido, H. Ishimoto, H. Ishii, K. Hara, H. Kawabata, T. Kawanami, Y. Suzuki, H. Yoshikawa, A. Hara, N. Sakamoto, N. Matsumoto, C. Yoshii, M. Fujita, M. Nakazato, J. Kadota, H. Mukae, K. Yatera
Organizer
ATS 2020-American Thoracic Society International Conference. Virtual
Related Report
Int'l Joint Research
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[Presentation] Heat Shock Protein 47 (HSP47) Positive Fibroblasts in Cancer Stroma Are Associated with Increased Risk of Postoperative Recurrence in Patients with Lung Cancer2020
Author(s)
T. Miyamura, N. Sakamoto, T. Kakugawa, K. Ishida, H. Taniguchi, D. Okuno, A. Hara, T. Kido, H. Ishimoto, T. Miyazaki, K. Matsumoto, T. Tsuchiya, H. Yamaguchi, Y. Obase, Y. Ishimatsu, T. Nagayasu, H. Mukae
Organizer
ATS 2020-American Thoracic Society International Conference. Virtual
Related Report
Int'l Joint Research
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[Presentation] 器質化像を呈し、ステロイドが有効であった石綿肺の一例2020
Author(s)
宮下律子, 城戸貴志, 入来 隼, 奥野大輔, 宮村拓人, 由良博一, 財前圭晃, 原 敦子, 山本和子, 石本裕士, 坂本憲穂, 尾長谷靖, 石松祐二, 福岡順也, 迎 寛
Organizer
第60回日本肺癌学会九州支部学術集会/第43回日本呼吸器内視鏡学会九州支部総会
Related Report
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[Presentation] 皮膚筋炎所見を呈さない抗MDA5抗体陽性急速進行性間質性肺炎の3例2019
Author(s)
坂本憲穂, 石本裕士, 中島章太, 由良博一, 宮村拓人, 奥野大輔, 原 敦子, 北崎 健, 角川智之, 石松祐二, , 佐藤 実, 迎 寛
Organizer
第59回日本呼吸器学会学術講演会
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[Presentation] Postoperative Acute Exacerbation of Interstitial Pneumonia in Pulmonary<and>for>Non-Pulmonary Surgery: A Retrospective Study2019
Author(s)
T. Miyamura, N. Sakamoto, T. Kakugawa, D. Okuno, H. Yura, S. Nakashima, H. Ishimoto, D. Taniguchi, T. Miyazaki, T. Tsuchiya, H. Yamaguchi, Y. Obase, Y. Ishimatsu, T. Nagayasu, H. Mukae
Organizer
ATS2019
Related Report
Int'l Joint Research
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[Presentation] Serum Soluble Interleukin-2 Receptor Is a Candidate Marker Differentiating Pneumocystis Jirovecii Pneumonia and Methotrexate-Induced Pneumonia in Patients with Rheumatoid Arthritis Under Methotrexate Therapy2019
Author(s)
N. Sakamoto, S. Hara, H. Ishimoto, S. Nakashima, H. Yura, T. Miyamura, D. Okuno, A. Hara, T. Kakugawa, H. Kushima, H. Ishii, S. Noguchi, T. Kido, Y. Ishimatsu, K. Yatera, J. Kadota, H. Mukae
Organizer
ATS2019
Related Report
Int'l Joint Research
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[Presentation] 急速に進行したじん肺の1例2019
Author(s)
林 史子, 坂本憲穂, 城戸貴志, 財前圭晃, 奥野大輔, 宮村拓人, 由良博一, 石本裕士, 尾長谷靖, 石松祐二, 迎 寛
Organizer
第83回日本呼吸器学会・日本結核病学会・日本サルコイドーシス/肉芽腫性疾患学会 九州支部 秋季学術講演会
Related Report
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[Presentation] 気管支肺胞洗浄液を用いた肺リンパ腫の分子生物学的診断手法の有効性2018
Author(s)
城戸 貴志, 川波 敏則, 石井 寛, 原 可奈子, 鈴木 雄, 吉川 裕喜, 松元 信弘, 石本 裕士, 原 敦子, 坂本 憲穂, 吉井 千春, 藤田 昌樹, 中里 雅光, 門田 淳一, 迎 寛, 矢寺 和博
Organizer
第58回日本呼吸器学会学術講演会
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[Presentation] 特発性間質性肺炎における抗Ro-52抗体陽性症例の検討2017
Author(s)
石本裕士, 由良博一, 花香哲也, 伊藤千与, 小田桂士, 原 敦子, 角川智之, 城戸貴志, 坂本憲穂, 石松祐二, 矢寺和博, 佐藤 実, 迎 寛
Organizer
第57回日本呼吸器学会・学術講演会
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[Presentation] 特発性間質性肺炎症例における抗ARS抗体の臨床的意義の検討2017
Author(s)
由良博一, 中島章太, 原 敦子, 角川智之, 石本裕士, 坂本憲穂, 小田桂士, 城戸貴志, 矢寺和博, 佐藤 実, 迎 寛
Organizer
第57回日本呼吸器学会・学術講演会
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