• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

sST2 is an important molecule in neutrophilic asthma: as a biomarker and a target for treatment

Research Project

Project/Area Number 17K09628
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKyorin University

Principal Investigator

Watanabe Masato  杏林大学, 医学部, 学内講師 (00458902)

Co-Investigator(Kenkyū-buntansha) 皿谷 健  杏林大学, 医学部, 准教授 (40549185)
滝澤 始  杏林大学, 医学部, 教授 (80171578)
田村 仁樹  杏林大学, 医学部, 助教 (80616607)
本多 紘二郎  杏林大学, 医学部, 助教 (20802995)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords喘息 / 好中球 / IL-33 / sST2 / ST2 / 重症喘息 / 気管支上皮細胞 / 感染 / 免疫 / バイオマーカー
Outline of Final Research Achievements

Neutrophilic asthma, characterized by neutrophil accumulation in the airways, is the most severe phenotype of asthma; thus, a strategy for controlling airway neutrophilia is desired to treat patients with severe asthma. We previously reported that sST2, a decoy receptor for IL-33, is associated with neutrophilic airway disease. Here, we hypothesized that sST2 plays a crucial role in pathogenesis of neutrophilic asthma. To address this, we conducted a clinical study assessing sputum and breath condensate from asthmatics and in vitro experiments using bronchial epithelial cells. We discovered that IL-33 facilitates airway neutrophilia, and that sST2 is an intrinsic regulator that ameliorates IL-33-related airway inflammation.

Academic Significance and Societal Importance of the Research Achievements

我々は、喘息患者の喀痰や呼気の解析と気管支上皮細胞の培養実験を組み合わせたトランスレーショナルリサーチを行った。その結果、喫煙、酸化ストレス、および好中球エラスターゼが気管支上皮細胞でIL-33の発現と放出を促進することと、IL-33は気管支上皮細胞のサイトカイン産生を増強して好中球性炎症を惹起することを発見した。sST2は重症喘息のバイオマーカーであるが、生理的な意義は抗炎症作用であった。我々の成果は、sST2補充療法が重症喘息の新規治療戦略になり得ることを示している。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Serum sST2 levels predict severe exacerbation of asthma2018

    • Author(s)
      Watanabe Masato、Nakamoto Keitaro、Inui Toshiya、Sada Mitsuru、Honda Kojiro、Tamura Masaki、Ogawa Yukari、Yokoyama Takuma、Saraya Takeshi、Kurai Daisuke、Ishii Haruyuki、Takizawa Hajime
    • Journal Title

      Respiratory Research

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12931-018-0872-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] IL-33/sST2 balance regulates neutrophilic inflammation in the human airways.2019

    • Author(s)
      4.M. Watanabe, K. Nakamoto, T. Inui, M. Sada, M. Oda, K. Honda, M. Tamura, H. Ishii, H. Takizawa
    • Organizer
      ERS International Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soluble ST2 (sST2)/ IL-33 Balance Regulates Neutrophil Chemotaxis Release from Bronchial Epithelial Cells2018

    • Author(s)
      Masato Watanabe, Mitsuru Sada, Keitaro Nakamoto, Toshiya Inui, Yukari Ogawa,Takuma Yokoyama, Koujiro Honda, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii, Hajime Takizawa
    • Organizer
      2018 ATS International Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] sST2/IL-33バランスは気管支上皮での 好中球ケモカイン産生を制御する2018

    • Author(s)
      渡辺雅人、中本啓太郎、佐田充、乾 俊哉、布川寛樹、麻生純平、田村仁樹、小田未来、小川ゆかり、 本多紘二郎、横山 琢磨、皿谷 健、倉井大輔、石井晴之、滝澤 始
    • Organizer
      日本呼吸器学会2018
    • Related Report
      2018 Research-status Report
  • [Presentation] sST2/IL-33 balance regulates neutrophilic inflammation in the human airways.2018

    • Author(s)
      Masato Watanabe, Toshiya Inui, Mitsuru Sada, Keitaro Nakamoto, Miku Oda, Yukari Ogawa,Takuma Yokoyama, Koujiro Honda, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii, and Hajime Takizawa.
    • Organizer
      World Congress of Athma 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Soluble ST2 (sST2)/ IL-33 balance regulates neutrophil-chemotaxis release from bronchial epithelial cells.2018

    • Author(s)
      Masato Watanabe
    • Organizer
      American Toracic Society 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] sST2/IL-33バランスは気管支上皮での 好中球ケモカイン産生を制御する2018

    • Author(s)
      渡辺 人
    • Organizer
      日本呼吸器学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Bacterial and viral infection enhances sST2 production by bronchial epithelial cells2017

    • Author(s)
      Masato Watanabe
    • Organizer
      American Toracic Society 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Serum sST2 levels predict severe exacerbation of asthma: A potential implication for neutrophilic asthma.2017

    • Author(s)
      Masato Watanabe
    • Organizer
      American Toracic Society 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi