Role of airway mucosal IgA in allergic diseases
| Project/Area Number |
17K09629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IgA / 肺線維芽細胞 / 特発性肺線維症 / サイトカイン / CD71 / 気道上皮細胞 / 細胞増殖 / TfR / 喘息 / アレルギー・ぜんそく / 呼吸器内科 / 免疫 |
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| Outline of Final Research Achievements |
The precise effects of IgA on lung fibroblasts remain unclear. This study aimed to elucidate how IgA activates human lung fibroblasts. Secretory IgA (sIgA) induced interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF) production by normal human lung fibroblasts (NHLFs). sIgA also promoted proliferation of NHLFs. Among known IgA receptors, NHLFs significantly expressed CD71. Immunohistochemistry revealed that sIgA is abundant in lung sections from patients with idiopathic pulmonary fibrosis (IPF). Our findings suggest that sIgA may promote human lung inflammation by activating human lung fibroblasts.
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| Academic Significance and Societal Importance of the Research Achievements |
気道粘膜を含め生体内において大量に存在する免疫グロブリンであり、抗原曝露の第一線に存在するIgAは、元来生体防御因子として重要視されてきたが、本研究から、肺の炎症を増強することで病原性役割があることが示唆された。本研究の結果を踏まえて、IgAが肺線維芽細胞を活性化する機構を明らかにできれば、IgAの役割の一部を標的とした予防あるいは治療戦略の確立につながる可能性がある。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Resequencing Study Confirms Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis2019
Author(s)
Moore C, Blumhagen Z, Yang V,Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, et al.
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Journal Title
American Journal of Respiratory and Critical Care Medicine
Volume: 印刷中
Issue: 2
Pages: 199-208
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] TBX4 is involved in the super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts.2018
Author(s)
Horie M, Miyashita N, Mikami Y, Noguchi S, Yamauchi Y, Suzukawa M, Fukami T, Ohta K, Asano Y, Sato S, Yamaguchi Y, Ohshima M, Suzuki HI, Saito A, Nagase T.
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Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: 314
Issue: 1
Pages: L177-L191
DOI
Related Report
Peer Reviewed / Open Access
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